Gene: Ihh

Basic information

Tag Content
Uniprot ID P97812; Q61724;
Entrez ID 16147
Genbank protein ID AAB49692.1; CAA53923.1;
Genbank nucleotide ID NM_010544.3
Ensembl protein ID ENSMUSP00000128056
Ensembl nucleotide ID ENSMUSG00000006538
Gene name Indian hedgehog protein
Gene symbol Ihh
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CLP
Developmental stage E14.5
Data sources Manually collected
Reference 26553654
Functional description Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
Sequence
MSPAWLRPRL RFCLFLLLLL LVPAARGCGP GRVVGSRRRP PRKLVPLAYK QFSPNVPEKT 60
LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD RLMTQRCKDR LNSLAISVMN 120
QWPGVKLRVT EGWDEDGHHS EESLHYEGRA VDITTSDRDR NKYGLLARLA VEAGFDWVYY 180
ESKAHVHCSV KSEHSAAAKT GGCFPAGAQV RLENGERVAL SAVKPGDRVL AMGEDGTPTF 240
SDVLIFLDRE PNRLRAFQVI ETQDPPRRLA LTPAHLLFIA DNHTEPAAHF RATFASHVQP 300
GQYVLVSGVP GLQPARVAAV STHVALGSYA PLTRHGTLVV EDVVASCFAA VADHHLAQLA 360
FWPLRLFPSL AWGSWTPSEG VHWYPQMLYR LGRLLLEEST FHPLGMSGAG S 411

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Gene expression information

Gene expression during embryonic days (E11.5~E18.5) ~ adult days (Ps) in the lip and palate tissues. (X-axis: days, Y-axis: tissues)

loading...

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologIHH102179616A0A452EW38Capra hircusPredictionMore>>
1:1 orthologIHH3549Q14623Homo sapiensPredictionMore>>
1:1 orthologIhh16147P97812CLPE14.5Mus musculusPublicationMore>>
1:1 orthologIHH470652H2QJG1Pan troglodytesPredictionMore>>
1:1 orthologIHH100008942G1U6S4Oryctolagus cuniculusPredictionMore>>
1:1 orthologIhh84399F1LP42Rattus norvegicusPredictionMore>>
1:1 orthologihhaB0S8K0Danio rerioPredictionMore>>

Other genetic variants/mutations

loading...

Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0005113 patched bindingISO
GO:0005113 patched bindingIBA
GO:0005113 patched bindingIPI
GO:0005509 calcium ion bindingISO
GO:0005509 calcium ion bindingIBA
GO:0005515 protein bindingIPI
GO:0008233 peptidase activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001501 skeletal system developmentISO
GO:0001501 skeletal system developmentIMP
GO:0001503 ossificationIMP
GO:0001569 branching involved in blood vessel morphogenesisIMP
GO:0001649 osteoblast differentiationIMP
GO:0001649 osteoblast differentiationIDA
GO:0001649 osteoblast differentiationIGI
GO:0001701 in utero embryonic developmentIMP
GO:0001708 cell fate specificationIMP
GO:0001708 cell fate specificationIBA
GO:0001763 morphogenesis of a branching structureIMP
GO:0001944 vasculature developmentIMP
GO:0001947 heart loopingIMP
GO:0002053 positive regulation of mesenchymal cell proliferationIMP
GO:0003382 epithelial cell morphogenesisIMP
GO:0003406 retinal pigment epithelium developmentIMP
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesisIMP
GO:0006029 proteoglycan metabolic processIGI
GO:0007224 smoothened signaling pathwayISO
GO:0007224 smoothened signaling pathwayIGI
GO:0007224 smoothened signaling pathwayIBA
GO:0007224 smoothened signaling pathwayIDA
GO:0007267 cell-cell signalingIEA
GO:0007389 pattern specification processIMP
GO:0008284 positive regulation of cell population proliferationIMP
GO:0008284 positive regulation of cell population proliferationIGI
GO:0009612 response to mechanical stimulusIEA
GO:0009880 embryonic pattern specificationIMP
GO:0010468 regulation of gene expressionIBA
GO:0016539 intein-mediated protein splicingIEA
GO:0030154 cell differentiationIDA
GO:0030704 vitelline membrane formationIMP
GO:0031016 pancreas developmentIMP
GO:0031016 pancreas developmentIGI
GO:0032355 response to estradiolIEA
GO:0032967 positive regulation of collagen biosynthetic processIDA
GO:0033085 negative regulation of T cell differentiation in thymusIMP
GO:0033088 negative regulation of immature T cell proliferation in thymusIMP
GO:0033089 positive regulation of T cell differentiation in thymusIMP
GO:0035264 multicellular organism growthIMP
GO:0035988 chondrocyte proliferationIMP
GO:0040008 regulation of growthIGI
GO:0042733 embryonic digit morphogenesisISO
GO:0042733 embryonic digit morphogenesisIGI
GO:0042733 embryonic digit morphogenesisIMP
GO:0043010 camera-type eye developmentIMP
GO:0043066 negative regulation of apoptotic processISO
GO:0045453 bone resorptionIDA
GO:0045596 negative regulation of cell differentiationIMP
GO:0045880 positive regulation of smoothened signaling pathwayIMP
GO:0045944 positive regulation of transcription by RNA polymerase IIIGI
GO:0046638 positive regulation of alpha-beta T cell differentiationIMP
GO:0046639 negative regulation of alpha-beta T cell differentiationIMP
GO:0048074 negative regulation of eye pigmentationIMP
GO:0048469 cell maturationIMP
GO:0048557 embryonic digestive tract morphogenesisIMP
GO:0048596 embryonic camera-type eye morphogenesisIMP
GO:0048666 neuron developmentIMP
GO:0048745 smooth muscle tissue developmentIMP
GO:0050679 positive regulation of epithelial cell proliferationISO
GO:0051216 cartilage developmentISO
GO:0051216 cartilage developmentIMP
GO:0060135 maternal process involved in female pregnancyIEA
GO:0060220 camera-type eye photoreceptor cell fate commitmentIMP
GO:0060323 head morphogenesisIMP
GO:0061053 somite developmentIMP
GO:0072498 embryonic skeletal joint developmentIMP
GO:0090136 epithelial cell-cell adhesionIMP
GO:0097421 liver regenerationIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005576 extracellular regionTAS
GO:0005615 extracellular spaceIBA
GO:0005886 plasma membraneISO
GO:0031012 extracellular matrixIDA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-162582 Signal TransductionIEA
R-MMU-5358346 Hedgehog ligand biogenesisIEA
R-MMU-5358351 Signaling by HedgehogIEA
R-MMU-5362798 Release of Hh-Np from the secreting cellIEA
R-MMU-5632681 Ligand-receptor interactionsIEA
R-MMU-5632684 Hedgehog 'on' stateIEA
R-MMU-5635838 Activation of SMOIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0068 Autocatalytic cleavage
KW-0106 Calcium
KW-1003 Cell membrane
KW-0217 Developmental protein
KW-0325 Glycoprotein
KW-0378 Hydrolase
KW-0449 Lipoprotein
KW-0472 Membrane
KW-0479 Metal-binding
KW-0564 Palmitate
KW-0645 Protease
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal
KW-0862 Zinc

Interpro

InterPro ID InterPro Term
IPR001657 Hedgehog
IPR001767 Hedgehog_Hint
IPR009045 Hedgehog_sig/DD-Pept_Zn-bd_sf
IPR000320 Hedgehog_signalling_dom
IPR003586 Hint_dom_C
IPR003587 Hint_dom_N
IPR036844 Hint_dom_sf
IPR033385 IHH
IPR006141 Intein_N

PROSITE

PROSITE ID PROSITE Term
PS50817 INTEIN_N_TER

Pfam

Pfam ID Pfam Term
PF01085 HH_signal
PF01079 Hint

Protein-miRNA interaction