| Tag | Content |
|---|---|
| Uniprot ID | F1LP42 |
| Entrez ID | 84399 |
| Genbank protein ID | EDL75378.1 |
| Genbank nucleotide ID | NM_053384.1 |
| Ensembl protein ID | ENSRNOP00000024419 |
| Ensembl nucleotide ID | ENSRNOG00000018059 |
| Gene name | Hedgehog protein |
| Gene symbol | Ihh |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Intercellular signal essential for a variety of patterning events during development. |
| Sequence | MSPAWLRPRL RFCLLLLLLL LVPAARGCGP GRVVGSRRRP PRKLVPLAYK QFSPNVPEKT 60 LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD RLMTQRCKDR LNSLAISVMN 120 QWPGVKLRVT EGWDEDGHHS EESLHYEGRA VDITTSDRDR NKYGLLARLA VEAGFDWVYY 180 ESKAHVHCSV KSEHSAAAKT GGCFPAGAQV HLETGERVAL SAVKPGDRVL AMGEDGNPTF 240 SDVLIFLDRE PNRLRAFQVI ETQDPPRRLA LTPAHLLFIA DNHTEPAARF RATFASHVQP 300 GQYVLVAGVP GLQPARVAAI STHVALGSYA PLTRHGTLVV EDVVASCFAA VSDHHLAQLA 360 FWPLRLFPSL PWGSWTPSEG VHWYPQLLYR LGRLLLEEST FHPLGMSGAG S 411 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IHH | 102179616 | A0A452EW38 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | IHH | 3549 | Q14623 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ihh | 16147 | P97812 | CLP | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | IHH | 470652 | H2QJG1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | IHH | 100008942 | G1U6S4 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Ihh | 84399 | F1LP42 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ihha | B0S8K0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005886 | plasma membrane |
| GO:0005509 | calcium ion binding |
| GO:0005113 | patched binding |
| GO:0008233 | peptidase activity |
| GO:0045453 | bone resorption |
| GO:0001569 | branching involved in blood vessel morphogenesis |
| GO:0043010 | camera-type eye development |
| GO:0060220 | camera-type eye photoreceptor cell fate commitment |
| GO:0051216 | cartilage development |
| GO:0030154 | cell differentiation |
| GO:0001708 | cell fate specification |
| GO:0048469 | cell maturation |
| GO:0007267 | cell-cell signaling |
| GO:0003413 | chondrocyte differentiation involved in endochondral bone morphogenesis |
| GO:0035988 | chondrocyte proliferation |
| GO:0048596 | embryonic camera-type eye morphogenesis |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0042733 | embryonic digit morphogenesis |
| GO:0009880 | embryonic pattern specification |
| GO:0072498 | embryonic skeletal joint development |
| GO:0003382 | epithelial cell morphogenesis |
| GO:0090136 | epithelial cell-cell adhesion |
| GO:0060323 | head morphogenesis |
| GO:0001947 | heart looping |
| GO:0001701 | in utero embryonic development |
| GO:0016539 | intein-mediated protein splicing |
| GO:0097421 | liver regeneration |
| GO:0060135 | maternal process involved in female pregnancy |
| GO:0001763 | morphogenesis of a branching structure |
| GO:0035264 | multicellular organism growth |
| GO:0046639 | negative regulation of alpha-beta T cell differentiation |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0045596 | negative regulation of cell differentiation |
| GO:0048074 | negative regulation of eye pigmentation |
| GO:0033088 | negative regulation of immature T cell proliferation in thymus |
| GO:0033085 | negative regulation of T cell differentiation in thymus |
| GO:0048666 | neuron development |
| GO:0001503 | ossification |
| GO:0001649 | osteoblast differentiation |
| GO:0031016 | pancreas development |
| GO:0007389 | pattern specification process |
| GO:0046638 | positive regulation of alpha-beta T cell differentiation |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032967 | positive regulation of collagen biosynthetic process |
| GO:0050679 | positive regulation of epithelial cell proliferation |
| GO:0002053 | positive regulation of mesenchymal cell proliferation |
| GO:0045880 | positive regulation of smoothened signaling pathway |
| GO:0033089 | positive regulation of T cell differentiation in thymus |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0016540 | protein autoprocessing |
| GO:0006029 | proteoglycan metabolic process |
| GO:0010468 | regulation of gene expression |
| GO:0040008 | regulation of growth |
| GO:0032355 | response to estradiol |
| GO:0009612 | response to mechanical stimulus |
| GO:0003406 | retinal pigment epithelium development |
| GO:0001501 | skeletal system development |
| GO:0048745 | smooth muscle tissue development |
| GO:0007224 | smoothened signaling pathway |
| GO:0061053 | somite development |
| GO:0001944 | vasculature development |
| GO:0030704 | vitelline membrane formation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS50817 | INTEIN_N_TER |