Gene: IHH

Basic information

Tag Content
Uniprot ID H2QJG1; A0A2J8NGB6;
Entrez ID 470652
Genbank protein ID
Genbank nucleotide ID XM_526034.6
Ensembl protein ID ENSPTRP00000022106
Ensembl nucleotide ID ENSPTRG00000012938
Gene name Hedgehog protein
Gene symbol IHH
Organism Pan troglodytes
NCBI taxa ID 9598
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Intercellular signal essential for a variety of patterning events during development.
Sequence
MSPARLRPQL HFCLLLLLLL VVPAAWGCGP GRVVGSRRRP PRKLVPLAYK QFSPNVPEKT 60
LGASGRYEGK IARSSERFKE LTPNYNPDII FKDEENTGAD RLMTQRCKDR LNSLAISVMN 120
QWPGVKLRVT EGWDEDGHHS EESLHYEGRA VDITTSDRDR NKYGLLARLA VEAGFDWVYY 180
ESKAHVHCSV KSEHSAAAKT GGCFPAGAQV RLESGARVAL SAVRPGDRVL AMGEDGSTTF 240
SDVLIFLDRE PHRLRVFQVI ETQDPPRRLA LTPAHLLFSA DNHTEPAARF RATFASHVQP 300
GQYVLVAGVP GLQPARVAAV STHVALGAYA PLTRHGTLVV EDVVASCFAA VADHHLAQLA 360
FWPLRLFHSL AWGSWTPGEG VHWYPQLLYR LGRLLLEEGS FHPLGMSGAG S 411

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologIHH102179616A0A452EW38Capra hircusPredictionMore>>
1:1 orthologIHH3549Q14623Homo sapiensPredictionMore>>
1:1 orthologIhh16147P97812CLPE14.5Mus musculusPublicationMore>>
1:1 orthologIHH470652H2QJG1Pan troglodytesPredictionMore>>
1:1 orthologIHH100008942G1U6S4Oryctolagus cuniculusPredictionMore>>
1:1 orthologIhh84399F1LP42Rattus norvegicusPredictionMore>>
1:1 orthologihhaB0S8K0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0031012 extracellular matrix
GO:0005615 extracellular space
GO:0005886 plasma membrane
GO:0005509 calcium ion binding
GO:0005113 patched binding
GO:0008233 peptidase activity
GO:0045453 bone resorption
GO:0001569 branching involved in blood vessel morphogenesis
GO:0060220 camera-type eye photoreceptor cell fate commitment
GO:0001708 cell fate specification
GO:0048469 cell maturation
GO:0007267 cell-cell signaling
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis
GO:0035988 chondrocyte proliferation
GO:0048596 embryonic camera-type eye morphogenesis
GO:0048557 embryonic digestive tract morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0009880 embryonic pattern specification
GO:0072498 embryonic skeletal joint development
GO:0003382 epithelial cell morphogenesis
GO:0090136 epithelial cell-cell adhesion
GO:0060323 head morphogenesis
GO:0001947 heart looping
GO:0001701 in utero embryonic development
GO:0016539 intein-mediated protein splicing
GO:0035264 multicellular organism growth
GO:0046639 negative regulation of alpha-beta T cell differentiation
GO:0048074 negative regulation of eye pigmentation
GO:0033088 negative regulation of immature T cell proliferation in thymus
GO:0048666 neuron development
GO:0001649 osteoblast differentiation
GO:0031016 pancreas development
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0002053 positive regulation of mesenchymal cell proliferation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0033089 positive regulation of T cell differentiation in thymus
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0016540 protein autoprocessing
GO:0006029 proteoglycan metabolic process
GO:0010468 regulation of gene expression
GO:0040008 regulation of growth
GO:0003406 retinal pigment epithelium development
GO:0048745 smooth muscle tissue development
GO:0007224 smoothened signaling pathway
GO:0061053 somite development
GO:0030704 vitelline membrane formation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0068 Autocatalytic cleavage
KW-1003 Cell membrane
KW-0217 Developmental protein
KW-0378 Hydrolase
KW-0472 Membrane
KW-0645 Protease
KW-1185 Reference proteome
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR001657 Hedgehog
IPR001767 Hedgehog_Hint
IPR009045 Hedgehog_sig/DD-Pept_Zn-bd_sf
IPR000320 Hedgehog_signalling_dom
IPR003586 Hint_dom_C
IPR003587 Hint_dom_N
IPR036844 Hint_dom_sf
IPR033385 IHH
IPR006141 Intein_N

PROSITE

PROSITE ID PROSITE Term
PS50817 INTEIN_N_TER

Pfam

Pfam ID Pfam Term
PF01085 HH_signal
PF01079 Hint