| Tag | Content |
|---|---|
| Uniprot ID | A0A452EYM7 |
| Entrez ID | 102178880 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018041966.1 |
| Ensembl protein ID | ENSCHIP00000017043 |
| Ensembl nucleotide ID | ENSCHIG00000017052 |
| Gene name | Uncharacterized protein |
| Gene symbol | ADGRA2 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGAAGRRMRG VPARLLLPLL LPWLLLLTPE TRGAPGCPVP IRSCKCSGER PKGLSGGAPN 60 PARRRVVCGG GDLPEPPDPG LLPNSTVTLL LSNNKITGLR SRAFLGLSLL EKLDLRNNVI 120 STVQPGAFLG LGELKRLDLS NNRIGCLTSG TFQGLPRLLR LNISGNIFSS LQPGVFDELP 180 ALKVVDFGTE FLTCDCRLRW LLPWARNRSL QLSERTLCAY PSALHAQALA GLQEAQLRCE 240 GALELHTLHL IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGVLLAD 300 SLVHDCTFIT SELTLSHIGV WASGEWECSV STVQGNASKK VEIVVLETSA SYCPAERVAN 360 NRGDFRWPRT LAGITAYQSC LQYPFTSVPL SGGAPGTRAS RRCDRAGRWE PGDYSHCLYT 420 NDITRVLYTF VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI 480 KELVEVMVDM ASNLMLVDEH LLWLAQREDK ACSGIVGALE RIGGAALSAH AQHISVNSRN 540 VALEAYLIKP HSYVGLTCTA FQRQEAGMPG TRHAGPGQSP SPEPEPLADQ QLRFRCTTGR 600 PNVSLSAFHI KNSVALASIQ LPPSLFSTPP AALAPPVPPD CTLQLLIFRN GRLFRTLGNT 660 SRPGATGPGR RRGVATPVIF AGTSGCGVGN LTEPVAVSLR HWAEGAEPVA AWWSQEGPGG 720 PGGWRSEGCQ LRSSQPNVSS LHCQHLGNVA VLMELSAFPR EAGGSGAGLH PVVYPCTALL 780 LLCLFSTIIT YILNHSSIHV SRKGWHMLLN LCFHMAMTSA VFAGGITLTN YQMVCQAVGI 840 TLHYSSLSTL LWMGVKARVL HKELTWRAPP PPEGDAAPPA PRPMLRFYLI AGGIPLIICG 900 ITAAVNIQNY RDHSPYCWLV WRPSLGAFYI PVALILLITW IYFLCAGLRL RGPLAQSPKG 960 GTGRVSLEPR EELRGSTRLR SSGPLLSDSG SLLAAGSTGM VTPGPPEDGD GLYSPGVQLG 1020 ALVTTHFLYL ATWACGALTV SQRWLPRVVC SCLYGVAASA LGLFVFTHHC ARRRDVRASW 1080 RACRPSASGS RASPRAVPAG PEDGSPVFGE GPPSLKSSPS GSSGHAPPPG PCKLTNLQLA 1140 QSQACEAEAA ARGEGEPETP GPRAGLGQRH PNNLHHGRRG HKSRAKGHRA GEAGGKNRLR 1200 ALRGGAAGAA ELQSSESGSP HHSPSESYLG SSRHSPGAGP RLEGETALTL SEGSDTSAAP 1260 PPEAGRPGQR RSASRDNLRG GALEKESKRR SYPLNSASLN GAPKGGKYDD VPSSGAEAAG 1320 GGCMKTGLWK SETTV 1335 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ADGRA2 | 102178880 | A0A452EYM7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ADGRA2 | 25960 | Q96PE1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | 78560 | Q91ZV8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ADGRA2 | 472739 | H2QW10 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | D4ADC7 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | adgra2 | F1Q989 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:1990909 | Wnt signalosome |
| GO:0004930 | G protein-coupled receptor activity |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0007417 | central nervous system development |
| GO:0043542 | endothelial cell migration |
| GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0010595 | positive regulation of endothelial cell migration |
| GO:0045765 | regulation of angiogenesis |
| GO:0050920 | regulation of chemotaxis |
| GO:0090210 | regulation of establishment of blood-brain barrier |
| GO:0002040 | sprouting angiogenesis |
| InterPro ID | InterPro Term |
|---|---|
| IPR000483 | Cys-rich_flank_reg_C |
| IPR017981 | GPCR_2-like |
| IPR036445 | GPCR_2_extracell_dom_sf |
| IPR001879 | GPCR_2_extracellular_dom |
| IPR000832 | GPCR_2_secretin-like |
| IPR017983 | GPCR_2_secretin-like_CS |
| IPR000203 | GPS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR001611 | Leu-rich_rpt |
| IPR003591 | Leu-rich_rpt_typical-subtyp |
| IPR032675 | LRR_dom_sf |