| Tag | Content |
|---|---|
| Uniprot ID | H2QW10 |
| Entrez ID | 472739 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016959331.1 |
| Ensembl protein ID | ENSPTRP00000034515 |
| Ensembl nucleotide ID | ENSPTRG00000020161 |
| Gene name | Adhesion G protein-coupled receptor A2 |
| Gene symbol | ADGRA2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGPGGRRMRG APARLLLPLL PWLLLLLAPE ARGAPGCPLP IRSCKCSGER PKGLSGGVPG 60 PARRRVVCSG GDLPEPPEPG LLPNGTVTLL LSNNKITGLR NGSFLGLSLL EKLDLRNNII 120 STVQPGAFLG LGELKRLDLS NNRIGCLTSE TFQGLPRLLR LNISGNIFSS LQPGVFDELP 180 ALKVVDLGTE FLTCDCHLRW LLPWAQNRSL QLSEHTLCAY PSALHAQALG SLQEAQLCCE 240 GALELHTHHL IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIR WYHNRAPVEG DEQAGILLAE 300 SLIHDCTFIT SELTLSHIGV WASGEWECTV SMAQGNASKK VEIVVLETSA SYCPAERVAN 360 NRGDFRWPRT LAGITAYQSC LQYPFTSVPL GGGAPGTRAS RRCDRAGRWE PGDYSHCLYT 420 NDITRVLYTF VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI 480 KELVEVMVDM ASNLMLVDEH LLWLAQREDK ACSRIVGALE RIGGAALSPH AQHISVNARN 540 VALEAYLIKP HSYVGLTCTA FQRREGGVPG TRPGSPGQNP PPEPEPPADQ QLRFRCTTGR 600 PNVSLSSFHI KNSVALASIQ LPPSLFSSLP AALAPPVPPD CTLQLLVFRN GRLFRSHSNT 660 SRPGAAGPGK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR HWAEGAEPVA AWWSQEGPGE 720 AGGWTSEGCQ LRSSQPNVSA LHCQHLGNVA VLMELSAFPR EVGGAGAGLH PVVYPCTALL 780 LLCLFATIIT YILNHSSIRV SRKGWHMLLN LCFHMAMTSA VFAGGITLTN YQMVCQAVGI 840 TLHYSSLSTL LWMGVKARVL HKELTWRAPP PQEGDPALPT PSPMLRFYLI AGGIPLIICG 900 ITAAVNIHNY RDHSPYCWLV WRPSLGAFYI PVALILLITW IYFLCAGLRL RGPLAQNPKA 960 GNSRASLEAG EELRGSTRLR GSGPLLSDSG SLLATGSARV GTPGPPEDGD SLYSPGVQLG 1020 ALVTTHFLYL AMWACGALAV SQRWLPRVVC SCLYGVAASA LGLFVFTHHC ARRRDVRASW 1080 RACCPPASPS APHAPPRALP AAAEDGSPVF GEGPPSLKSS PSGSSGHPLA LGPCKLTNLQ 1140 LAQSQVCEAG AAAGGEGEPE PAGTRGNLAH RHPNNVHHGR RAHKSRAKGH RAGEACGKNR 1200 LKALRGGAAG APELLSSESG SLHNSPTDSY LGSSRNSPGA GLQLEGEPML TPSEGSDTSA 1260 APLSEAGRAG QRRSASRDSL KGGGALEKES HRRSYPLNAA SLNGAPKGGK YDDVTVMGAE 1320 VASGGCMKTG LWKSETTV 1338 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ADGRA2 | 102178880 | A0A452EYM7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ADGRA2 | 25960 | Q96PE1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | 78560 | Q91ZV8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ADGRA2 | 472739 | H2QW10 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | D4ADC7 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | adgra2 | F1Q989 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:1990909 | Wnt signalosome |
| GO:0004930 | G protein-coupled receptor activity |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0007417 | central nervous system development |
| GO:0043542 | endothelial cell migration |
| GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0010595 | positive regulation of endothelial cell migration |
| GO:0045765 | regulation of angiogenesis |
| GO:0050920 | regulation of chemotaxis |
| GO:0090210 | regulation of establishment of blood-brain barrier |
| GO:0002040 | sprouting angiogenesis |
| InterPro ID | InterPro Term |
|---|---|
| IPR000483 | Cys-rich_flank_reg_C |
| IPR017981 | GPCR_2-like |
| IPR036445 | GPCR_2_extracell_dom_sf |
| IPR001879 | GPCR_2_extracellular_dom |
| IPR000832 | GPCR_2_secretin-like |
| IPR017983 | GPCR_2_secretin-like_CS |
| IPR000203 | GPS |
| IPR007110 | Ig-like_dom |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR001611 | Leu-rich_rpt |
| IPR003591 | Leu-rich_rpt_typical-subtyp |
| IPR032675 | LRR_dom_sf |