| Tag | Content |
|---|---|
| Uniprot ID | Q91ZV8; B2RRK0; |
| Entrez ID | 78560 |
| Genbank protein ID | AAI38452.1; AAI38453.1; AAL11996.1; |
| Genbank nucleotide ID | NM_054044.2 |
| Ensembl protein ID | ENSMUSP00000033876 |
| Ensembl nucleotide ID | ENSMUSG00000031486 |
| Gene name | Adhesion G protein-coupled receptor A2 |
| Gene symbol | Adgra2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 21282641 |
| Functional description | Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:25373781, PubMed:25558062, PubMed:28803732). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (PubMed:21071672, PubMed:21282641, PubMed:21421844, PubMed:25373781, PubMed:28288111). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). ADGRA2-tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (By similarity). |
| Sequence | MGAGGRRMPV PPARLLLLPL LPCLLLLAPG TRGAPGCPVP IRGCKCSGER PKGLSGGAHN 60 PARRRVVCGG GDLPEPPDPG LLPNGTITLL LSNNKITGLR NGSFLGLSLL EKLDLRSNVI 120 STVQPGAFLG LGELKRLDLS NNRIGCLTSE TFQGLPRLLR LNISGNIYSS LQPGVFDELP 180 ALKIVDFGTE FLTCDCRLRW LLPWARNHSL QLSERTLCAY PSALHAHALS SLQESQLRCE 240 GALELHTHYL IPSLRQVVFQ GDRLPFQCSA SYLGNDTRIH WYHNGAPMES DEQAGIVLAE 300 NLIHDCTFIT SELTLSHIGV WASGEWECSV STVQGNTSKK VEIVVLETSA SYCPAERVTN 360 NRGDFRWPRT LAGITAYQSC LQYPFTSVPL SGGAPGTRAS RRCDRAGRWE PGDYSHCLYT 420 NDITRVLYTF VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI 480 KELVEVMVDM ASNLMLVDEH LLWLAQREDK ACSGIVGALE RIGGAALSPH AQHISVNSRN 540 VALEAYLIKP HSYVGLTCTA FQRREVGVSG AQPSSVGQDA PVEPEPLADQ QLRFRCTTGR 600 PNISLSSFHI KNSVALASIQ LPPSLFSTLP AALAPPVPPD CTLQLLVFRN GRLFRSHGNN 660 TSRPGAAGPG KRRGVATPVI FAGTSGCGVG NLTEPVAVSL RHWAEGADPM AAWWNQDGPG 720 GWSSEGCRLR YSQPNVSSLY CQHLGNVAVL MELNAFPREA GGSGAGLHPV VYPCTALLLL 780 CLFSTIITYI LNHSSIHVSR KGWHMLLNLC FHMAMTSAVF VGGVTLTNYQ MVCQAVGITL 840 HYSSLSSLLW MGVKARVLHK ELSWRAPPLE EGEAAPPGPR PMLRFYLIAG GIPLIICGIT 900 AAVNIHNYRD HSPYCWLVWR PSLGAFYIPV ALILPITWIY FLCAGLHLRS HVAQNPKQGN 960 RISLEPGEEL RGSTRLRSSG VLLNDSGSLL ATVSAGVGTP APPEDGDGVY SPGVQLGALM 1020 TTHFLYLAMW ACGALAVSQR WLPRVVCSCL YGVAASALGL FVFTHHCARR RDVRASWRAC 1080 CPPASPSASH VPARALPTAT EDGSPVLGEG PASLKSSPSG SSGRAPPPPC KLTNLQVAQS 1140 QVCEASVAAR GDGEPEPTGS RGSLAPRHHN NLHHGRRVHK SRAKGHRAGE TGGKSRLKAL 1200 RAGTSPGAPE LLSSESGSLH NSPSDSYPGS SRNSPGDGLP LEGEPMLTPS EGSDTSAAPI 1260 AETGRPGQRR SASRDNLKGS GSALERESKR RSYPLNTTSL NGAPKGGKYE DASVTGAEAI 1320 AGGSMKTGLW KSETTV 1336 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ADGRA2 | 102178880 | A0A452EYM7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ADGRA2 | 25960 | Q96PE1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | 78560 | Q91ZV8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ADGRA2 | 472739 | H2QW10 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | D4ADC7 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | adgra2 | F1Q989 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004930 | G protein-coupled receptor activity | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001525 | angiogenesis | IMP |
| GO:0002040 | sprouting angiogenesis | IMP |
| GO:0002040 | sprouting angiogenesis | IBA |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA |
| GO:0007417 | central nervous system development | IMP |
| GO:0010595 | positive regulation of endothelial cell migration | IDA |
| GO:0016055 | Wnt signaling pathway | IEA |
| GO:0043542 | endothelial cell migration | IMP |
| GO:0045765 | regulation of angiogenesis | IMP |
| GO:0050920 | regulation of chemotaxis | IMP |
| GO:0090210 | regulation of establishment of blood-brain barrier | IMP |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | ISO |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IDA |
| GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0009986 | cell surface | IDA |
| GO:0016021 | integral component of membrane | IEA |
| GO:0030175 | filopodium | IEA |
| GO:1990909 | Wnt signalosome | ISS |
| GO:1990909 | Wnt signalosome | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0037 | Angiogenesis |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0393 | Immunoglobulin domain |
| KW-0433 | Leucine-rich repeat |
| KW-0472 | Membrane |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |
| InterPro ID | InterPro Term |
|---|---|
| IPR000483 | Cys-rich_flank_reg_C |
| IPR017981 | GPCR_2-like |
| IPR036445 | GPCR_2_extracell_dom_sf |
| IPR001879 | GPCR_2_extracellular_dom |
| IPR000832 | GPCR_2_secretin-like |
| IPR017983 | GPCR_2_secretin-like_CS |
| IPR000203 | GPS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR001611 | Leu-rich_rpt |
| IPR003591 | Leu-rich_rpt_typical-subtyp |
| IPR032675 | LRR_dom_sf |