| Tag | Content |
|---|---|
| Uniprot ID | D4ADC7 |
| Entrez ID | |
| Genbank protein ID | EDM09091.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000017776 |
| Ensembl nucleotide ID | ENSRNOG00000012991 |
| Gene name | Adhesion G protein-coupled receptor A2 |
| Gene symbol | Adgra2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGAGGRRMPV RSARLLLLPL LPCLLLLAPG TRGAPGCPVP IRGCKCSGER PKGLSGGAHN 60 PARRRVVCGG GDLPEPPDPG LLPNGTITLL LSNNKITGLR NGSFLGLSLL EKLDLRSNVI 120 STVQPGAFLG LGELKRLDLS NNRIGCLTSE TFQGLPRLLR LNISGNIYSS LQPGVFDELP 180 DLKIVDFGTE FLTCDCRLRW LLPWARNHSL QLSERTLCAY PSALHAHALS SLQESQLRCE 240 GALELHTHYL IPSLRQVVFQ GDRLPFQCSA SYLGNDTQIH WYHNGAPMES DEQAGIVLAE 300 NLIHDCTFIT SELTLSHIGV WASGEWECSV STVQGNTSKK VEIVVLETSA SYCPAERVTN 360 NRGDFRWPRT LAGITAYQSC LQYPFTSVPL SGGAPGTRAS RRCDRAGRWE PGDYSHCLYT 420 NDITRVLYTF VLMPINASNA LTLAHQLRVY TAEAASFSDM MDVVYVAQMI QKFLGYVDQI 480 KELVEVMVDM ASNLMLVDEH LLWLAQREDK ACSGIVGALE RIGGAALSPH AQHISVNSRN 540 VALEAYLIKP HSYVGLTCTA FQRREVGVSG VQPSSPGQDV PLEPEALADQ QLRFRCTTGR 600 PNVSLSSFHI KNSVALASIQ LPPSLFSTLP AALAPPVPPD CTLQLLVFRN GRLFRSHGNT 660 SRPGTAEPSK RRGVATPVIF AGTSGCGVGN LTEPVAVSLR HWAEGTDPLA AWWNQDGPGG 720 WSSEGCKLRF SQPNVSSLYC QHLGNVAVLM ELSAFPREAG GSGAGLHPVV YPCTALLLLC 780 LFSTIITYIL NHSSIHVSRK GWHMLLNLCF HMAMTSAVFV GGVTLTNYQM VCQAVGITLH 840 YSSLSSLLWM GVKARVLHKE LSWRAPPPEE GEAAPPGPRP MLRFYLIAGG IPLIICGITA 900 AVNIHNYRDH SPYCWLVWRP SLGAFYIPVA LILPITWIYF LCAGLHLRGH VAQNPKQGNS 960 RLSLEPGEDP RGSTRLRSSG VLLSDSGSLL ATVSAGVGTP APPEESDGVY SPGVQLGALM 1020 TTHFLYLAMW ACGALAVSQR WLPRVVCSCL YGVAASALGL FVFTHHCARR RDVRASWRAC 1080 CPPASPSASH APPRALPTAA EDGSPVLGEG PASLKSSPSG SSGRAPPPPC KLTNLQVAQS 1140 QVCEASMVAR GDGEPEPTGS RSSLAPRHHN NLHHGRRVHK SRAKGHRAGE TGGKSRLKAL 1200 RAGTSPGAPE LLSSESGSLH NSPSDSYPGS SRNSPGDGLP LEGEPMLTPS EGSDTSAAQI 1260 PETGRPGQRR SASRDNLKGS GSALERESKR RSYPLNTTSL NGAPKGGKYE DASVTGAEAI 1320 AGGCMKTGLW KSETTV 1336 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ADGRA2 | 102178880 | A0A452EYM7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ADGRA2 | 25960 | Q96PE1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | 78560 | Q91ZV8 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ADGRA2 | 472739 | H2QW10 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | Adgra2 | D4ADC7 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | adgra2 | F1Q989 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:1990909 | Wnt signalosome |
| GO:0004930 | G protein-coupled receptor activity |
| GO:0001525 | angiogenesis |
| GO:0007166 | cell surface receptor signaling pathway |
| GO:0007417 | central nervous system development |
| GO:0043542 | endothelial cell migration |
| GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0010595 | positive regulation of endothelial cell migration |
| GO:0045765 | regulation of angiogenesis |
| GO:0050920 | regulation of chemotaxis |
| GO:0090210 | regulation of establishment of blood-brain barrier |
| GO:0002040 | sprouting angiogenesis |
| InterPro ID | InterPro Term |
|---|---|
| IPR000483 | Cys-rich_flank_reg_C |
| IPR017981 | GPCR_2-like |
| IPR036445 | GPCR_2_extracell_dom_sf |
| IPR001879 | GPCR_2_extracellular_dom |
| IPR000832 | GPCR_2_secretin-like |
| IPR017983 | GPCR_2_secretin-like_CS |
| IPR000203 | GPS |
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR003599 | Ig_sub |
| IPR001611 | Leu-rich_rpt |
| IPR003591 | Leu-rich_rpt_typical-subtyp |
| IPR032675 | LRR_dom_sf |