| Tag | Content |
|---|---|
| Uniprot ID | A0A452F960 |
| Entrez ID | 102177271 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_018061157.1 |
| Ensembl protein ID | ENSCHIP00000020822 |
| Ensembl nucleotide ID | ENSCHIG00000019333 |
| Gene name | Tyrosine-protein phosphatase non-receptor type |
| Gene symbol | PTPN11 |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 120 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDAKSKVTHV MIRCQELKYD 180 VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360 ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 420 RTWPDHGVPS DPGGVLDFLE EVHHKQESIV DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 480 EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH 540 EYTNIKYSLT DQASGDQSPL PPCTPTPSCA EMREDNARVY ENVGLMQQQK SFR 593 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPN11 | 477488 | A0A4D6PF96 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 102177271 | A0A452F960 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 5781 | Q06124 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptpn11 | 19247 | P35235 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PTPN11 | I3L916 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ptpn11 | 25622 | P41499 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ptpn11a | F1QZU5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005634 | nucleus |
| GO:0032991 | protein-containing complex |
| GO:0045296 | cadherin binding |
| GO:0005158 | insulin receptor binding |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| GO:0051428 | peptide hormone receptor binding |
| GO:0001784 | phosphotyrosine residue binding |
| GO:0030971 | receptor tyrosine kinase binding |
| GO:0005070 | SH3/SH2 adaptor activity |
| GO:0033277 | abortive mitotic cell cycle |
| GO:0000187 | activation of MAPK activity |
| GO:0036302 | atrioventricular canal development |
| GO:0007409 | axonogenesis |
| GO:0060020 | Bergmann glial cell differentiation |
| GO:0071364 | cellular response to epidermal growth factor stimulus |
| GO:0021697 | cerebellar cortex formation |
| GO:0000077 | DNA damage checkpoint |
| GO:0048013 | ephrin receptor signaling pathway |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0060325 | face morphogenesis |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0048806 | genitalia development |
| GO:0042593 | glucose homeostasis |
| GO:0048873 | homeostasis of number of cells within a tissue |
| GO:0042445 | hormone metabolic process |
| GO:0009755 | hormone-mediated signaling pathway |
| GO:0048839 | inner ear development |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0061582 | intestinal epithelial cell migration |
| GO:0035855 | megakaryocyte development |
| GO:0032528 | microvillus organization |
| GO:0035264 | multicellular organism growth |
| GO:0048609 | multicellular organismal reproductive process |
| GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| GO:0051463 | negative regulation of cortisol secretion |
| GO:0060125 | negative regulation of growth hormone secretion |
| GO:0046676 | negative regulation of insulin secretion |
| GO:0048011 | neurotrophin TRK receptor signaling pathway |
| GO:0035265 | organ growth |
| GO:0030220 | platelet formation |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0046326 | positive regulation of glucose import |
| GO:0046887 | positive regulation of hormone secretion |
| GO:0046628 | positive regulation of insulin receptor signaling pathway |
| GO:0032728 | positive regulation of interferon-beta production |
| GO:0032755 | positive regulation of interleukin-6 production |
| GO:0045931 | positive regulation of mitotic cell cycle |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0032760 | positive regulation of tumor necrosis factor production |
| GO:0046825 | regulation of protein export from nucleus |
| GO:0043254 | regulation of protein-containing complex assembly |
| GO:0006641 | triglyceride metabolic process |