| Tag | Content |
|---|---|
| Uniprot ID | F1QZU5 |
| Entrez ID | |
| Genbank protein ID | CBX19678.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSDARP00000076040 |
| Ensembl nucleotide ID | ENSDARG00000020334 |
| Gene name | Tyrosine-protein phosphatase non-receptor type |
| Gene symbol | ptpn11a |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGR 120 EAEKLLTEKG KNGSFLVRES QSHPGDFVLS VRTGDDKTDT SDGKPKVTHV MIRCQHDLKY 180 DVGGGEKFDS LTDLVEHYKK NPMVETLGTV LQLKQPLNTT RINAAEIESR VRELSKLAEA 240 TDKVKQGFWE EFETLQQQEC KLLYSRKEGQ RPENKNKNRY KNILPFDHTR VVLTDGDVNE 300 QGSDYINANL IMPDNEAKSN NSKLKRSYIA TQGCLQNTIS DFWRMVFQEN SRVIVMTTKE 360 VERGKSKCVK YWPDVSALKE YGAMRVRNVK ETMAHDYILR ELKLSKVGQG NTERTVWQYH 420 FRAWPDHGVP GDPGGVLDFL EEVKLKQEGI TGAGPIVVHC SAGIGRTGTF IVIDILIDII 480 REKGVDCDID VPKTIQMVRS QRSGMVQTEA QYRFIYMAVQ HYIETLQRRI EEEQKSKIKG 540 REYTNIKYSL SDLSGGDQSP LPPCTPTPTC ADMRDDSSRV YENVGLMQQQ KSHR 594 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPN11 | 477488 | A0A4D6PF96 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 102177271 | A0A452F960 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 5781 | Q06124 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptpn11 | 19247 | P35235 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PTPN11 | I3L916 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ptpn11 | 25622 | P41499 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ptpn11a | F1QZU5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0016791 | phosphatase activity |
| GO:0004725 | protein tyrosine phosphatase activity |
| GO:0060028 | convergent extension involved in axis elongation |
| GO:0060027 | convergent extension involved in gastrulation |
| GO:0048703 | embryonic viscerocranium morphogenesis |
| GO:0007507 | heart development |
| GO:0003146 | heart jogging |
| GO:0060548 | negative regulation of cell death |