Gene: PTPN11

Basic information

Tag Content
Uniprot ID I3L916
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSSSCP00000020527
Ensembl nucleotide ID ENSSSCG00000030289
Gene name Protein tyrosine phosphatase non-receptor type 11
Gene symbol PTPN11
Organism Sus scrofa
NCBI taxa ID 9823
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MEHHGQLKEK NGDVIELKYP LNCADPTSER WFHGHLSGKE AEKLLTEKGK HGSFLVRESQ 60
SHPGDFVLSV RTGDDKGESN DGKSKVTHVM IRCQELKYDV GGGERFDSLT DLVEHYKKNP 120
MVETLGTVLQ LKQPLNTTRI NAAEIESRVR ELSKLAETTD KVKQGFWEEF ETLQQQECKL 180
LYSRKEGQRQ ENKNKNRYKN ILPFDHTRVV LHDGDPNEPV SDYINANIIM PEFETKCNNS 240
KPKKSYIATQ GCLQNTVNDF WRMVFQENSR VIVMTTKEVE RGKSKCVKYW PDEYALKEYG 300
VMRVRNVKES AAHDYTLREL KLSKVGQGNT ERTVWQYHFR TWPDHGVPSD PGGVLDFLEE 360
VHHKQESIMD AGPVVVHCSA GIGRTGTFIV IDILIDIIRE KGVDCDIDVP KTIQMVRSQR 420
SGMVQTEAQY RFIYMAVQHY IETLQRRIEE EQKSKRKGHE YTNIKYSLTD QAGGEQSPLP 480
PCTPTPSCAE MREDNARVYE NVGLMQQQKS FR 512

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPTPN11477488A0A4D6PF96Canis lupus familiarisPredictionMore>>
1:1 orthologPTPN11102177271A0A452F960Capra hircusPredictionMore>>
1:1 orthologPTPN115781Q06124Homo sapiensPredictionMore>>
1:1 orthologPtpn1119247P35235CPOMus musculusPublicationMore>>
1:1 orthologPTPN11I3L916Sus scrofaPredictionMore>>
1:1 orthologPtpn1125622P41499Rattus norvegicusPredictionMore>>
1:1 orthologptpn11aF1QZU5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0004725 protein tyrosine phosphatase activity

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0378 Hydrolase
KW-0904 Protein phosphatase
KW-1267 Proteomics identification
KW-1185 Reference proteome
KW-0727 SH2 domain

Interpro

InterPro ID InterPro Term
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom

PROSITE

PROSITE ID PROSITE Term
PS50001 SH2
PS00383 TYR_PHOSPHATASE_1
PS50056 TYR_PHOSPHATASE_2
PS50055 TYR_PHOSPHATASE_PTP

Pfam

Pfam ID Pfam Term
PF00017 SH2
PF00102 Y_phosphatase