Gene: Ptpn11

Basic information

Tag Content
Uniprot ID P41499; Q62626;
Entrez ID 25622
Genbank protein ID AAA20543.1; AAA19133.1;
Genbank nucleotide ID NM_001177593.1; NM_013088.2;
Ensembl protein ID ENSRNOP00000041842
Ensembl nucleotide ID ENSRNOG00000030124
Gene name Tyrosine-protein phosphatase non-receptor type 11
Gene symbol Ptpn11
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (By similarity). Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity).
Sequence
MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 60
DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 120
EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDSKSKVTHV MIRCQELKYD 180
VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240
DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360
ERGKSKCVKY WPDECALKEY GVMRVRNVRE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 420
RTWPDHGVPS DPGGVLDFLE EVHHKQESIV DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 480
EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH 540
EYTNIKYSLV DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQR SFR 593

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologPTPN11477488A0A4D6PF96Canis lupus familiarisPredictionMore>>
1:1 orthologPTPN11102177271A0A452F960Capra hircusPredictionMore>>
1:1 orthologPTPN115781Q06124Homo sapiensPredictionMore>>
1:1 orthologPtpn1119247P35235CPOMus musculusPublicationMore>>
1:1 orthologPTPN11I3L916Sus scrofaPredictionMore>>
1:1 orthologPtpn1125622P41499Rattus norvegicusPredictionMore>>
1:1 orthologptpn11aF1QZU5Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005739 mitochondrion
GO:0005634 nucleus
GO:0032991 protein-containing complex
GO:0045296 cadherin binding
GO:0050839 cell adhesion molecule binding
GO:0031748 D1 dopamine receptor binding
GO:0005158 insulin receptor binding
GO:0043560 insulin receptor substrate binding
GO:0004726 non-membrane spanning protein tyrosine phosphatase activity
GO:0051428 peptide hormone receptor binding
GO:0043274 phospholipase binding
GO:0004721 phosphoprotein phosphatase activity
GO:0001784 phosphotyrosine residue binding
GO:0019904 protein domain specific binding
GO:0019901 protein kinase binding
GO:1990782 protein tyrosine kinase binding
GO:0004725 protein tyrosine phosphatase activity
GO:0030971 receptor tyrosine kinase binding
GO:0005070 SH3/SH2 adaptor activity
GO:0033277 abortive mitotic cell cycle
GO:0000187 activation of MAPK activity
GO:0036302 atrioventricular canal development
GO:0007409 axonogenesis
GO:0060020 Bergmann glial cell differentiation
GO:0007420 brain development
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071260 cellular response to mechanical stimulus
GO:0021697 cerebellar cortex formation
GO:0000077 DNA damage checkpoint
GO:0048013 ephrin receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0038127 ERBB signaling pathway
GO:0060325 face morphogenesis
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0048806 genitalia development
GO:0042593 glucose homeostasis
GO:0007507 heart development
GO:0048873 homeostasis of number of cells within a tissue
GO:0042445 hormone metabolic process
GO:0009755 hormone-mediated signaling pathway
GO:0048839 inner ear development
GO:0007229 integrin-mediated signaling pathway
GO:0061582 intestinal epithelial cell migration
GO:0006629 lipid metabolic process
GO:0035855 megakaryocyte development
GO:0032528 microvillus organization
GO:0035264 multicellular organism growth
GO:0048609 multicellular organismal reproductive process
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0051463 negative regulation of cortisol secretion
GO:0060125 negative regulation of growth hormone secretion
GO:0046888 negative regulation of hormone secretion
GO:0046676 negative regulation of insulin secretion
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0035265 organ growth
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0030220 platelet formation
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0046326 positive regulation of glucose import
GO:0046887 positive regulation of hormone secretion
GO:0046628 positive regulation of insulin receptor signaling pathway
GO:0032728 positive regulation of interferon-beta production
GO:0032755 positive regulation of interleukin-6 production
GO:0045931 positive regulation of mitotic cell cycle
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0009967 positive regulation of signal transduction
GO:0032760 positive regulation of tumor necrosis factor production
GO:0006470 protein dephosphorylation
GO:0033628 regulation of cell adhesion mediated by integrin
GO:0046825 regulation of protein export from nucleus
GO:0043254 regulation of protein-containing complex assembly
GO:0006641 triglyceride metabolic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0025 Alternative splicing
KW-0963 Cytoplasm
KW-0903 Direct protein sequencing
KW-0378 Hydrolase
KW-0597 Phosphoprotein
KW-0904 Protein phosphatase
KW-1185 Reference proteome
KW-0677 Repeat
KW-0727 SH2 domain

Interpro

InterPro ID InterPro Term
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR012152 Tyr_Pase_non-rcpt_typ-6/11
IPR000387 TYR_PHOSPHATASE_dom

PROSITE

PROSITE ID PROSITE Term
PS50001 SH2
PS00383 TYR_PHOSPHATASE_1
PS50056 TYR_PHOSPHATASE_2
PS50055 TYR_PHOSPHATASE_PTP

Pfam

Pfam ID Pfam Term
PF00017 SH2
PF00102 Y_phosphatase