| Tag | Content |
|---|---|
| Uniprot ID | P41499; Q62626; |
| Entrez ID | 25622 |
| Genbank protein ID | AAA20543.1; AAA19133.1; |
| Genbank nucleotide ID | NM_001177593.1; NM_013088.2; |
| Ensembl protein ID | ENSRNOP00000041842 |
| Ensembl nucleotide ID | ENSRNOG00000030124 |
| Gene name | Tyrosine-protein phosphatase non-receptor type 11 |
| Gene symbol | Ptpn11 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (By similarity). Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (By similarity). |
| Sequence | MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 120 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDSKSKVTHV MIRCQELKYD 180 VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360 ERGKSKCVKY WPDECALKEY GVMRVRNVRE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 420 RTWPDHGVPS DPGGVLDFLE EVHHKQESIV DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 480 EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH 540 EYTNIKYSLV DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQR SFR 593 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPN11 | 477488 | A0A4D6PF96 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 102177271 | A0A452F960 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 5781 | Q06124 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptpn11 | 19247 | P35235 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PTPN11 | I3L916 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ptpn11 | 25622 | P41499 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ptpn11a | F1QZU5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0005739 | mitochondrion |
| GO:0005634 | nucleus |
| GO:0032991 | protein-containing complex |
| GO:0045296 | cadherin binding |
| GO:0050839 | cell adhesion molecule binding |
| GO:0031748 | D1 dopamine receptor binding |
| GO:0005158 | insulin receptor binding |
| GO:0043560 | insulin receptor substrate binding |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| GO:0051428 | peptide hormone receptor binding |
| GO:0043274 | phospholipase binding |
| GO:0004721 | phosphoprotein phosphatase activity |
| GO:0001784 | phosphotyrosine residue binding |
| GO:0019904 | protein domain specific binding |
| GO:0019901 | protein kinase binding |
| GO:1990782 | protein tyrosine kinase binding |
| GO:0004725 | protein tyrosine phosphatase activity |
| GO:0030971 | receptor tyrosine kinase binding |
| GO:0005070 | SH3/SH2 adaptor activity |
| GO:0033277 | abortive mitotic cell cycle |
| GO:0000187 | activation of MAPK activity |
| GO:0036302 | atrioventricular canal development |
| GO:0007409 | axonogenesis |
| GO:0060020 | Bergmann glial cell differentiation |
| GO:0007420 | brain development |
| GO:0071364 | cellular response to epidermal growth factor stimulus |
| GO:0071260 | cellular response to mechanical stimulus |
| GO:0021697 | cerebellar cortex formation |
| GO:0000077 | DNA damage checkpoint |
| GO:0048013 | ephrin receptor signaling pathway |
| GO:0007173 | epidermal growth factor receptor signaling pathway |
| GO:0038127 | ERBB signaling pathway |
| GO:0060325 | face morphogenesis |
| GO:0008543 | fibroblast growth factor receptor signaling pathway |
| GO:0048806 | genitalia development |
| GO:0042593 | glucose homeostasis |
| GO:0007507 | heart development |
| GO:0048873 | homeostasis of number of cells within a tissue |
| GO:0042445 | hormone metabolic process |
| GO:0009755 | hormone-mediated signaling pathway |
| GO:0048839 | inner ear development |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0061582 | intestinal epithelial cell migration |
| GO:0006629 | lipid metabolic process |
| GO:0035855 | megakaryocyte development |
| GO:0032528 | microvillus organization |
| GO:0035264 | multicellular organism growth |
| GO:0048609 | multicellular organismal reproductive process |
| GO:0033629 | negative regulation of cell adhesion mediated by integrin |
| GO:0051463 | negative regulation of cortisol secretion |
| GO:0060125 | negative regulation of growth hormone secretion |
| GO:0046888 | negative regulation of hormone secretion |
| GO:0046676 | negative regulation of insulin secretion |
| GO:0048011 | neurotrophin TRK receptor signaling pathway |
| GO:0035265 | organ growth |
| GO:0035335 | peptidyl-tyrosine dephosphorylation |
| GO:0030220 | platelet formation |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0046326 | positive regulation of glucose import |
| GO:0046887 | positive regulation of hormone secretion |
| GO:0046628 | positive regulation of insulin receptor signaling pathway |
| GO:0032728 | positive regulation of interferon-beta production |
| GO:0032755 | positive regulation of interleukin-6 production |
| GO:0045931 | positive regulation of mitotic cell cycle |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0009967 | positive regulation of signal transduction |
| GO:0032760 | positive regulation of tumor necrosis factor production |
| GO:0006470 | protein dephosphorylation |
| GO:0033628 | regulation of cell adhesion mediated by integrin |
| GO:0046825 | regulation of protein export from nucleus |
| GO:0043254 | regulation of protein-containing complex assembly |
| GO:0006641 | triglyceride metabolic process |