| Tag | Content |
|---|---|
| Uniprot ID | P35235; Q3TQ84; Q64509; Q6PCL5; |
| Entrez ID | 19247 |
| Genbank protein ID | BAA12328.1; BAE35207.1; BAE35134.1; AAH59278.1; BAE37500.1; AAH57398.1; |
| Genbank nucleotide ID | NM_001109992.1; NM_011202.3; |
| Ensembl protein ID | ENSMUSP00000098333; ENSMUSP00000058757; |
| Ensembl nucleotide ID | ENSMUSG00000043733 |
| Gene name | Tyrosine-protein phosphatase non-receptor type 11 |
| Gene symbol | Ptpn11 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19706403; 19541608; |
| Functional description | Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:14967142). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115). |
| Sequence | MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG 60 DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK 120 EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD 180 VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT 240 DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP 300 VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV 360 ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF 420 RTWPDHGVPS DPGGVLDFLE EVHHKQESIV DAGPVVVHCS AGIGRTGTFI VIDILIDIIR 480 EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH 540 EYTNIKYSLV DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQR SFR 593 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PTPN11 | 477488 | A0A4D6PF96 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 102177271 | A0A452F960 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PTPN11 | 5781 | Q06124 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Ptpn11 | 19247 | P35235 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | PTPN11 | I3L916 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Ptpn11 | 25622 | P41499 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | ptpn11a | F1QZU5 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001784 | phosphotyrosine residue binding | ISO |
| GO:0004721 | phosphoprotein phosphatase activity | ISO |
| GO:0004721 | phosphoprotein phosphatase activity | IMP |
| GO:0004725 | protein tyrosine phosphatase activity | ISO |
| GO:0004725 | protein tyrosine phosphatase activity | IDA |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity | ISS |
| GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity | ISO |
| GO:0005070 | SH3/SH2 adaptor activity | ISO |
| GO:0005158 | insulin receptor binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0019901 | protein kinase binding | IPI |
| GO:0019904 | protein domain specific binding | ISO |
| GO:0030971 | receptor tyrosine kinase binding | ISO |
| GO:0030971 | receptor tyrosine kinase binding | IPI |
| GO:0031748 | D1 dopamine receptor binding | ISO |
| GO:0043274 | phospholipase binding | ISO |
| GO:0043560 | insulin receptor substrate binding | ISO |
| GO:0045296 | cadherin binding | ISO |
| GO:0050839 | cell adhesion molecule binding | ISO |
| GO:0050839 | cell adhesion molecule binding | IPI |
| GO:0051428 | peptide hormone receptor binding | IPI |
| GO:1990782 | protein tyrosine kinase binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000077 | DNA damage checkpoint | IMP |
| GO:0000187 | activation of MAPK activity | IMP |
| GO:0006470 | protein dephosphorylation | ISO |
| GO:0006629 | lipid metabolic process | IMP |
| GO:0006641 | triglyceride metabolic process | IMP |
| GO:0007173 | epidermal growth factor receptor signaling pathway | IGI |
| GO:0007229 | integrin-mediated signaling pathway | IMP |
| GO:0007409 | axonogenesis | IMP |
| GO:0007420 | brain development | ISO |
| GO:0007507 | heart development | ISO |
| GO:0008543 | fibroblast growth factor receptor signaling pathway | IEA |
| GO:0009755 | hormone-mediated signaling pathway | IDA |
| GO:0009967 | positive regulation of signal transduction | IMP |
| GO:0021697 | cerebellar cortex formation | IGI |
| GO:0021697 | cerebellar cortex formation | IMP |
| GO:0030220 | platelet formation | IGI |
| GO:0032528 | microvillus organization | IMP |
| GO:0032728 | positive regulation of interferon-beta production | IMP |
| GO:0032755 | positive regulation of interleukin-6 production | IGI |
| GO:0032760 | positive regulation of tumor necrosis factor production | IGI |
| GO:0033277 | abortive mitotic cell cycle | IMP |
| GO:0033628 | regulation of cell adhesion mediated by integrin | ISS |
| GO:0033628 | regulation of cell adhesion mediated by integrin | ISO |
| GO:0033629 | negative regulation of cell adhesion mediated by integrin | IMP |
| GO:0035264 | multicellular organism growth | IMP |
| GO:0035265 | organ growth | IMP |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | ISS |
| GO:0035335 | peptidyl-tyrosine dephosphorylation | ISO |
| GO:0035855 | megakaryocyte development | IMP |
| GO:0036302 | atrioventricular canal development | ISO |
| GO:0038127 | ERBB signaling pathway | ISO |
| GO:0042445 | hormone metabolic process | IMP |
| GO:0042593 | glucose homeostasis | IMP |
| GO:0043254 | regulation of protein-containing complex assembly | ISO |
| GO:0045931 | positive regulation of mitotic cell cycle | IGI |
| GO:0046326 | positive regulation of glucose import | ISO |
| GO:0046628 | positive regulation of insulin receptor signaling pathway | ISO |
| GO:0046676 | negative regulation of insulin secretion | IMP |
| GO:0046825 | regulation of protein export from nucleus | IMP |
| GO:0046887 | positive regulation of hormone secretion | IMP |
| GO:0046888 | negative regulation of hormone secretion | IMP |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IGI |
| GO:0048011 | neurotrophin TRK receptor signaling pathway | IMP |
| GO:0048013 | ephrin receptor signaling pathway | ISS |
| GO:0048013 | ephrin receptor signaling pathway | ISO |
| GO:0048609 | multicellular organismal reproductive process | IMP |
| GO:0048806 | genitalia development | ISO |
| GO:0048839 | inner ear development | ISO |
| GO:0048873 | homeostasis of number of cells within a tissue | IGI |
| GO:0048873 | homeostasis of number of cells within a tissue | IMP |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | ISO |
| GO:0051463 | negative regulation of cortisol secretion | IMP |
| GO:0060020 | Bergmann glial cell differentiation | IGI |
| GO:0060020 | Bergmann glial cell differentiation | IMP |
| GO:0060125 | negative regulation of growth hormone secretion | IMP |
| GO:0060325 | face morphogenesis | ISO |
| GO:0061582 | intestinal epithelial cell migration | IMP |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISS |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | IGI |
| GO:0071260 | cellular response to mechanical stimulus | ISO |
| GO:0071364 | cellular response to epidermal growth factor stimulus | ISS |
| GO:0071364 | cellular response to epidermal growth factor stimulus | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005739 | mitochondrion | ISO |
| GO:0005829 | cytosol | ISO |
| GO:0005829 | cytosol | TAS |
| GO:0032991 | protein-containing complex | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1059683 | Interleukin-6 signaling | IEA |
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-109704 | PI3K Cascade | IEA |
| R-MMU-110056 | MAPK3 (ERK1) activation | IEA |
| R-MMU-112399 | IRS-mediated signalling | IEA |
| R-MMU-112409 | RAF-independent MAPK1/3 activation | IEA |
| R-MMU-112411 | MAPK1 (ERK2) activation | IEA |
| R-MMU-114604 | GPVI-mediated activation cascade | IEA |
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1266738 | Developmental Biology | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-1280218 | Adaptive Immune System | IEA |
| R-MMU-1295596 | Spry regulation of FGF signaling | IEA |
| R-MMU-1433557 | Signaling by SCF-KIT | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-166016 | Toll Like Receptor 4 (TLR4) Cascade | IEA |
| R-MMU-166166 | MyD88-independent TLR4 cascade | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-168898 | Toll-like Receptor Cascades | IEA |
| R-MMU-177929 | Signaling by EGFR | IEA |
| R-MMU-180292 | GAB1 signalosome | IEA |
| R-MMU-186763 | Downstream signal transduction | IEA |
| R-MMU-186797 | Signaling by PDGF | IEA |
| R-MMU-190236 | Signaling by FGFR | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-202733 | Cell surface interactions at the vascular wall | IEA |
| R-MMU-210990 | PECAM1 interactions | IEA |
| R-MMU-210993 | Tie2 Signaling | IEA |
| R-MMU-212436 | Generic Transcription Pathway | IEA |
| R-MMU-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | IEA |
| R-MMU-2428924 | IGF1R signaling cascade | IEA |
| R-MMU-2428928 | IRS-related events triggered by IGF1R | IEA |
| R-MMU-388841 | Costimulation by the CD28 family | IEA |
| R-MMU-389513 | CTLA4 inhibitory signaling | IEA |
| R-MMU-389948 | PD-1 signaling | IEA |
| R-MMU-418346 | Platelet homeostasis | IEA |
| R-MMU-422475 | Axon guidance | IEA |
| R-MMU-432142 | Platelet sensitization by LDL | IEA |
| R-MMU-449147 | Signaling by Interleukins | IEA |
| R-MMU-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling | IEA |
| R-MMU-5654687 | Downstream signaling of activated FGFR1 | IEA |
| R-MMU-5654689 | PI-3K cascade:FGFR1 | IEA |
| R-MMU-5654693 | FRS-mediated FGFR1 signaling | IEA |
| R-MMU-5654695 | PI-3K cascade:FGFR2 | IEA |
| R-MMU-5654696 | Downstream signaling of activated FGFR2 | IEA |
| R-MMU-5654700 | FRS-mediated FGFR2 signaling | IEA |
| R-MMU-5654706 | FRS-mediated FGFR3 signaling | IEA |
| R-MMU-5654708 | Downstream signaling of activated FGFR3 | IEA |
| R-MMU-5654710 | PI-3K cascade:FGFR3 | IEA |
| R-MMU-5654712 | FRS-mediated FGFR4 signaling | IEA |
| R-MMU-5654716 | Downstream signaling of activated FGFR4 | IEA |
| R-MMU-5654720 | PI-3K cascade:FGFR4 | IEA |
| R-MMU-5654726 | Negative regulation of FGFR1 signaling | IEA |
| R-MMU-5654727 | Negative regulation of FGFR2 signaling | IEA |
| R-MMU-5654732 | Negative regulation of FGFR3 signaling | IEA |
| R-MMU-5654733 | Negative regulation of FGFR4 signaling | IEA |
| R-MMU-5654736 | Signaling by FGFR1 | IEA |
| R-MMU-5654738 | Signaling by FGFR2 | IEA |
| R-MMU-5654741 | Signaling by FGFR3 | IEA |
| R-MMU-5654743 | Signaling by FGFR4 | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-6783589 | Interleukin-6 family signaling | IEA |
| R-MMU-6806834 | Signaling by MET | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-73857 | RNA Polymerase II Transcription | IEA |
| R-MMU-74160 | Gene expression (Transcription) | IEA |
| R-MMU-74751 | Insulin receptor signalling cascade | IEA |
| R-MMU-74752 | Signaling by Insulin receptor | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-8853659 | RET signaling | IEA |
| R-MMU-8854691 | Interleukin-20 family signaling | IEA |
| R-MMU-8865999 | MET activates PTPN11 | IEA |
| R-MMU-8878171 | Transcriptional regulation by RUNX1 | IEA |
| R-MMU-8934593 | Regulation of RUNX1 Expression and Activity | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-909733 | Interferon alpha/beta signaling | IEA |
| R-MMU-912694 | Regulation of IFNA signaling | IEA |
| R-MMU-913531 | Interferon Signaling | IEA |
| R-MMU-936964 | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | IEA |
| R-MMU-937061 | TRIF(TICAM1)-mediated TLR4 signaling | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| R-MMU-9645139 | Stat5 Activation | TAS |