Gene: MYH9

Basic information

Tag Content
Uniprot ID A0A452FAS7
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSCHIP00000021370
Ensembl nucleotide ID ENSCHIG00000019705
Gene name Uncharacterized protein
Gene symbol MYH9
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MAQQAADKYL YVDKNFINNP LAQADWAAKK LVWVPSDKSG FEPASLKEEM GEEAIVELVE 60
NGKKVKVNKD DIQKMNPPKF SKVEDMAELT CLNEASVLHN LKERYYSGLI YTYSGLFCVV 120
INPYKNLPIY SEEIVEMYKG KKRHEMPPHI YAITDTAYRS MMQDREDQSI LCTGESGAGK 180
TENTKKVIQY LAHVASSHKS KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR 240
INFDVNGYIV GANIETYLLE KSRAIRQAKE ERTFHIFYYL LSGAGEHLKS DLLLESYNKY 300
RFLSNGHVTI PGQQDKDMFQ ETMEAFRIMG IPEEEQMGLL RVISGVLQLG NIVFKKERNS 360
DQASMPDNTA AQKVSHLLGI NVTDFTRGIL TPRIKVGRDY VQKAQTKEQA DFAIEALAKA 420
TYERMFRWLV LRINKALDKT KRQGASFIGI LDIAGFEIFD LNSFEQLCIN YTNEKLQQLF 480
NHTMFILEQE EYQREGIEWN FIDFGLDLQP CIDLIEKPAG PPGILALLDE ECWFPKATDK 540
SFVEKVMQEQ GTHPKFQKPK QLKDKADFCI IHYAGKVDYK ADEWLMKNMD PLNDNIATLL 600
HQSSDKFVSE LWKDEMQSTQ RAYFYQRFPI LHLEPVDRII GLDQVAGMSE TAMPGAFKTR 660
KGMFRTVGQL YKEQLAKLMA TLRNTNPNFV RCIIPNHEKK AGKLDPHLVL DQLRCNGVLE 720
GIRICRQGFP NRVVFQEFRQ RYEILTPNSI PKGFMDGKQA CVLMIKALEL DSNLYRIGQS 780
KVFFRAGVLA HLEEERDLKI TDVIIGFQAC CRGYLARKAF AKRQQQLTAM KVLQRNCAAY 840
LKLRNWQWWR LFTKVKPLLQ VSRQEEEMMA KEEELVKVRE KQLAAENRLS EMETLQSQLM 900
AEKLQLQEQL QAETELCAEA EELRARLTAK KQELEEICHD LEARVEEEEE RCQHLQAEKK 960
KMQQNIQELE EQLEEEESAR QKLQLEKVTT EAKLKKLEED QIIMEDQNCK LAKEKKLLED 1020
RIAEFTTNLM EEEEKSKSLA KLKNKHEAMI TDLEERLRRE EKQRQELEKT RRKLEGDSTD 1080
LNDQIAELQA QIAELKMQLA KKEEELQAAL ARVEEETTQK NMALKKIREL ESQISELQED 1140
LESERAARNK AEKQKRDLGE ELEALKTELE DTLDSTAAQQ ELRSKREQEV NILKKTLEEE 1200
ARTHEAQIQD MRQKHSQAVE ELAEQLEQTK RVKANLEKAK QTLENERGEL ANEVKVLQQG 1260
KADTEHKRKK VEAQLQELQL KFTEGERVRT ELADKVSKLQ VELDNVTGLL TQSDSKSSKL 1320
TKDFSALESQ LQDTQELLQE ENRQKLSLST KLKQVEDEKN SLKEQLEEEE EAKRNLEKQI 1380
STLHAQVTDM RKKMDDSVGC LETAEEAKRK LQKDLEGLSQ RYEEKVAAYD KLEKTKTRLQ 1440
QELDDLLVDL DHQRQSVSSL EKKQKKFDQL LAEEKTISAK YAEERDRAEA EAREKETKAL 1500
SLARALEEAM EQKAELERLN KQFRAEMEDL MSSKDDVGKS VHELEKSKRA LEQQVEEMKT 1560
QLEELEDELQ ATEDAKLRLE VNLQAMKAQF ERDLQGRDEQ SEEKKKQLVK QVREMEAELE 1620
DERKQRSIAV AARKKLEMDL KDLEAHIDSA NKNRDEAIKQ LRKLQAQMKD YMRELDDTRA 1680
SREEILAQAK ENEKKLKSME AEMIQLQEEL AAAERAKRQA QQERDELADE IANSSGKGAL 1740
ALEEKRRLEA RIAQLEEELE EEQGNTELVN DRLKKANLQI DQLNTDLNLE RSHTQKNENA 1800
RQQLERQNKE LKVKLQEMEG TVKSKYKASI TALEAKIAQL EEQLDNETKE RQAACKQVRR 1860
AEKKLKDVLL QVDDERRNAE QYKDQADKAS TRLKQLKRQL EEAEEEAQRA NASRRKLQRE 1920
LEDATETADA MNREVSSLKN KLRRGDLPFV VPRRMARKGA SDCSDDEMDG KADGAEAKAA 1980
EARAAE 1986

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologMYH9F1P9J3Canis lupus familiarisPredictionMore>>
1:1 orthologMYH9A0A452FAS7Capra hircusPredictionMore>>
1:1 orthologMYH94627P35579CPO,CL/PHomo sapiensPublicationMore>>
1:1 orthologMyh917886Q8VDD5Mus musculusPredictionMore>>
1:1 orthologMYH9A0A2I3T2I7Pan troglodytesPredictionMore>>
1:1 orthologMyh925745G3V6P7Rattus norvegicusPredictionMore>>
1:1 orthologmyh9bF1QJK4Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005826 actomyosin contractile ring
GO:0005912 adherens junction
GO:0005903 brush border
GO:0005623 cell
GO:0032154 cleavage furrow
GO:0008180 COP9 signalosome
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0001772 immunological synapse
GO:0016460 myosin II complex
GO:0097513 myosin II filament
GO:0031594 neuromuscular junction
GO:0001726 ruffle
GO:0005819 spindle
GO:0001725 stress fiber
GO:0001931 uropod
GO:0051015 actin filament binding
GO:0030898 actin-dependent ATPase activity
GO:0043531 ADP binding
GO:0005524 ATP binding
GO:0005178 integrin binding
GO:0000146 microfilament motor activity
GO:0019904 protein domain specific binding
GO:0042803 protein homodimerization activity
GO:0043495 protein membrane adaptor activity
GO:0031532 actin cytoskeleton reorganization
GO:0030048 actin filament-based movement
GO:0031032 actomyosin structure organization
GO:0001525 angiogenesis
GO:0043534 blood vessel endothelial cell migration
GO:0098609 cell-cell adhesion
GO:0032506 cytokinetic process
GO:0051295 establishment of meiotic spindle localization
GO:0001768 establishment of T cell polarity
GO:0001701 in utero embryonic development
GO:0032418 lysosome localization
GO:0000212 meiotic spindle organization
GO:0006509 membrane protein ectodomain proteolysis
GO:0030224 monocyte differentiation
GO:0007520 myoblast fusion
GO:1903919 negative regulation of actin filament severing
GO:0006911 phagocytosis, engulfment
GO:0001778 plasma membrane repair
GO:0030220 platelet formation
GO:1903923 positive regulation of protein processing in phagocytic vesicle
GO:0015031 protein transport
GO:0045055 regulated exocytosis
GO:0008360 regulation of cell shape
GO:1905684 regulation of plasma membrane repair
GO:0032796 uropod organization

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0009 Actin-binding
KW-0067 ATP-binding
KW-0175 Coiled coil
KW-0505 Motor protein
KW-0518 Myosin
KW-0547 Nucleotide-binding
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR000048 IQ_motif_EF-hand-BS
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase

PROSITE

PROSITE ID PROSITE Term
PS50096 IQ
PS51456 MYOSIN_MOTOR
PS51844 SH3_LIKE

Pfam

Pfam ID Pfam Term
PF00063 Myosin_head
PF02736 Myosin_N
PF01576 Myosin_tail_1