| Tag | Content |
|---|---|
| Uniprot ID | Q8VDD5; Q3UHT9; Q3UHU4; Q6KAN6; Q811I2; |
| Entrez ID | 17886 |
| Genbank protein ID | CAC85955.1; BAE27777.1; BAE27768.1; BAE27767.1; BAE27894.1; BAE27783.1; BAE27829.1; BAE27773.1; BAE27778.1; BAE27776.1; BAE27766.1; AAH44834.1; BAE27785.1; BAE27765.1; BAE27906.1; BAE27772.1; BAD21421.1; BAE27763.1; BAE27761.1; |
| Genbank nucleotide ID | NM_022410.3 |
| Ensembl protein ID | ENSMUSP00000016771 |
| Ensembl nucleotide ID | ENSMUSG00000022443 |
| Gene name | Myosin-9 |
| Gene symbol | Myh9 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. |
| Sequence | MAQQAADKYL YVDKNFINNP LAQADWAAKK LVWVPSSKNG FEPASLKEEV GEEAIVELVE 60 NGKKVKVNKD DIQKMNPPKF SKVEDMAELT CLNEASVLHN LKERYYSGLI YTYSGLFCVV 120 INPYKNLPIY SEEIVEMYKG KKRHEMPPHI YAITDTAYRS MMQDREDQSI LCTGESGAGK 180 TENTKKVIQY LAHVASSHKS KKDQGELERQ LLQANPILEA FGNAKTVKND NSSRFGKFIR 240 INFDVNGYIV GANIETYLLE KSRAIRQAKE ERTFHIFYYL LSGAGEHLKT DLLLEPYNKY 300 RFLSNGHVTI PGQQDKDMFQ ETMEAMRIMG IPEDEQMGLL RVISGVLQLG NIAFKKERNT 360 DQASMPDNTA AQKVSHLLGI NVTDFTRGIL TPRIKVGRDY VQKAQTKEQA DFAIEALAKA 420 TYERMFRWLV LRINKALDKT KRQGASFIGI LDIAGFEIFD LNSFEQLCIN YTNEKLQQLF 480 NHTMFILEQE EYQREGIEWN FIDFGLDLQP CIDLIEKPAG PPGILALLDE ECWFPKATDK 540 SFVEKVVQEQ GTHPKFQKPK QLKDKADFCI IHYAGKVDYK ADEWLMKNMD PLNDNIATLL 600 HQSSDKFVSE LWKDVDRIIG LDQVAGMSET ALPGAFKTRK GMFRTVGQLY KEQLAKLMAT 660 LRNTNPNFVR CIIPNHEKKA GKLDPHLVLD QLRCNGVLEG IRICRQGFPN RVVFQEFRQR 720 YEILTPNSIP KGFMDGKQAC VLMIKALELD SNLYRIGQSK VFFRAGVLAH LEEERDLKIT 780 DVIIGFQACC RGYLARKAFA KRQQQLTAMK VLQRNCAAYL RLRNWQWWRL FTKVKPLLNS 840 IRHEDELLAK EAELTKVREK HLAAENRLTE METMQSQLMA EKLQLQEQLQ AETELCAEAE 900 ELRARLTAKK QELEEICHDL EARVEEEEER CQYLQAEKKK MQQNIQELEE QLEEEESARQ 960 KLQLEKVTTE AKLKKLEEDQ IIMEDQNCKL AKEKKLLEDR VAEFTTNLME EEEKSKSLAK 1020 LKNKHEAMIT DLEERLRREE KQRQELEKTR RKLEGDSTDL SDQIAELQAQ IAELKMQLAK 1080 KEEELQAALA RVEEEAAQKN MALKKIRELE TQISELQEDL ESERASRNKA EKQKRDLGEE 1140 LEALKTELED TLDSTAAQQE LRSKREQEVS ILKKTLEDEA KTHEAQIQEM RQKHSQAVEE 1200 LADQLEQTKR VKATLEKAKQ TLENERGELA NEVKALLQGK GDSEHKRKKV EAQLQELQVK 1260 FSEGERVRTE LADKVTKLQV ELDSVTGLLS QSDSKSSKLT KDFSALESQL QDTQELLQEE 1320 NRQKLSLSTK LKQMEDEKNS FREQLEEEEE AKRNLEKQIA TLHAQVTDMK KKMEDGVGCL 1380 ETAEEAKRRL QKDLEGLSQR LEEKVAAYDK LEKTKTRLQQ ELDDLLVDLD HQRQSVSNLE 1440 KKQKKFDQLL AEEKTISAKY AEERDRAEAE AREKETKALS LARALEEAME QKAELERLNK 1500 QFRTEMEDLM SSKDDVGKSV HELEKSKRAL EQQVEEMKTQ LEELEDELQA TEDAKLRLEV 1560 NLQAMKAQFE RDLQGRDEQS EEKKKQLVRQ VREMEAELED ERKQRSMAMA ARKKLEMDLK 1620 DLEAHIDTAN KNREEAIKQL RKLQAQMKDC MRELDDTRAS REEILAQAKE NEKKLKSMEA 1680 EMIQLQEELA AAERAKRQAQ QERDELADEI ANSSGKGALA LEEKRRLEAR IAQLEEELEE 1740 EQGNTELIND RLKKANLQID QINTDLNLER SHAQKNENAR QQLERQNKEL KAKLQEMESA 1800 VKSKYKASIA ALEAKIAQLE EQLDNETKER QAASKQVRRT EKKLKDVLLQ VEDERRNAEQ 1860 FKDQADKAST RLKQLKRQLE EAEEEAQRAN ASRRKLQREL EDATETADAM NREVSSLKNK 1920 LRRGDLPFVV TRRIVRKGTG DCSDEEVDGK ADGADAKAAE |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MYH9 | F1P9J3 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | MYH9 | A0A452FAS7 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | MYH9 | 4627 | P35579 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Myh9 | 17886 | Q8VDD5 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | MYH9 | A0A2I3T2I7 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | Myh9 | 25745 | G3V6P7 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | myh9b | F1QJK4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000146 | microfilament motor activity | ISO |
| GO:0000146 | microfilament motor activity | ISS |
| GO:0003779 | actin binding | ISO |
| GO:0005178 | integrin binding | ISS |
| GO:0005178 | integrin binding | ISO |
| GO:0005515 | protein binding | IPI |
| GO:0005516 | calmodulin binding | IEA |
| GO:0005524 | ATP binding | ISO |
| GO:0016887 | ATPase activity | ISS |
| GO:0016887 | ATPase activity | ISO |
| GO:0019904 | protein domain specific binding | ISO |
| GO:0019904 | protein domain specific binding | IPI |
| GO:0030898 | actin-dependent ATPase activity | ISO |
| GO:0042803 | protein homodimerization activity | ISS |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0043495 | protein membrane adaptor | ISS |
| GO:0043495 | protein membrane adaptor | ISO |
| GO:0043531 | ADP binding | ISO |
| GO:0051015 | actin filament binding | ISO |
| GO:0051015 | actin filament binding | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000212 | meiotic spindle organization | IDA |
| GO:0000904 | cell morphogenesis involved in differentiation | IMP |
| GO:0001525 | angiogenesis | ISS |
| GO:0001525 | angiogenesis | ISO |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001768 | establishment of T cell polarity | IMP |
| GO:0001778 | plasma membrane repair | ISO |
| GO:0006509 | membrane protein ectodomain proteolysis | ISS |
| GO:0006509 | membrane protein ectodomain proteolysis | ISO |
| GO:0006911 | phagocytosis, engulfment | IMP |
| GO:0007155 | cell adhesion | IMP |
| GO:0007520 | myoblast fusion | IMP |
| GO:0008360 | regulation of cell shape | ISS |
| GO:0008360 | regulation of cell shape | ISO |
| GO:0008360 | regulation of cell shape | IMP |
| GO:0015031 | protein transport | ISS |
| GO:0015031 | protein transport | ISO |
| GO:0030048 | actin filament-based movement | ISO |
| GO:0030048 | actin filament-based movement | ISS |
| GO:0030220 | platelet formation | ISS |
| GO:0030220 | platelet formation | ISO |
| GO:0030224 | monocyte differentiation | ISS |
| GO:0031032 | actomyosin structure organization | ISO |
| GO:0031532 | actin cytoskeleton reorganization | ISS |
| GO:0031532 | actin cytoskeleton reorganization | ISO |
| GO:0032418 | lysosome localization | ISO |
| GO:0032506 | cytokinetic process | ISS |
| GO:0032506 | cytokinetic process | ISO |
| GO:0032796 | uropod organization | IMP |
| GO:0043534 | blood vessel endothelial cell migration | ISS |
| GO:0043534 | blood vessel endothelial cell migration | ISO |
| GO:0045055 | regulated exocytosis | ISO |
| GO:0051295 | establishment of meiotic spindle localization | IDA |
| GO:0098609 | cell-cell adhesion | IMP |
| GO:1903919 | negative regulation of actin filament severing | ISO |
| GO:1903919 | negative regulation of actin filament severing | IMP |
| GO:1903923 | positive regulation of protein processing in phagocytic vesicle | IMP |
| GO:1905684 | regulation of plasma membrane repair | ISO |
| GO:0030041 | actin filament polymerization | IDA |
| GO:0051693 | actin filament capping | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001725 | stress fiber | ISO |
| GO:0001725 | stress fiber | ISS |
| GO:0001725 | stress fiber | IDA |
| GO:0001726 | ruffle | ISS |
| GO:0001726 | ruffle | ISO |
| GO:0001931 | uropod | ISO |
| GO:0001931 | uropod | IDA |
| GO:0005623 | cell | IEA |
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005826 | actomyosin contractile ring | ISS |
| GO:0005826 | actomyosin contractile ring | ISO |
| GO:0005829 | cytosol | ISS |
| GO:0005829 | cytosol | ISO |
| GO:0005886 | plasma membrane | ISS |
| GO:0005903 | brush border | IDA |
| GO:0005912 | adherens junction | IDA |
| GO:0005938 | cell cortex | IDA |
| GO:0015629 | actin cytoskeleton | ISS |
| GO:0015629 | actin cytoskeleton | ISO |
| GO:0016459 | myosin complex | IDA |
| GO:0016460 | myosin II complex | ISO |
| GO:0016460 | myosin II complex | IDA |
| GO:0030863 | cortical cytoskeleton | IDA |
| GO:0031252 | cell leading edge | ISS |
| GO:0031252 | cell leading edge | ISO |
| GO:0032154 | cleavage furrow | ISS |
| GO:0032154 | cleavage furrow | ISO |
| GO:0032991 | protein-containing complex | ISS |
| GO:0032991 | protein-containing complex | ISO |
| GO:0042641 | actomyosin | ISO |
| GO:0097513 | myosin II filament | ISO |
| GO:0001772 | immunological synapse | ISO |
| GO:0001772 | immunological synapse | IDA |
| GO:0005819 | spindle | IDA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005886 | plasma membrane | IDA |
| GO:0005925 | focal adhesion | IDA |
| GO:0008180 | COP9 signalosome | ISO |
| GO:0031594 | neuromuscular junction | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-194315 | Signaling by Rho GTPases | IEA |
| R-MMU-195258 | RHO GTPase Effectors | IEA |
| R-MMU-2029480 | Fcgamma receptor (FCGR) dependent phagocytosis | IEA |
| R-MMU-2029482 | Regulation of actin dynamics for phagocytic cup formation | IEA |
| R-MMU-5627123 | RHO GTPases activate PAKs | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0007 | Acetylation |
| KW-0009 | Actin-binding |
| KW-0067 | ATP-binding |
| KW-0112 | Calmodulin-binding |
| KW-0130 | Cell adhesion |
| KW-0133 | Cell shape |
| KW-0175 | Coiled coil |
| KW-0963 | Cytoplasm |
| KW-0206 | Cytoskeleton |
| KW-0903 | Direct protein sequencing |
| KW-0488 | Methylation |
| KW-0505 | Motor protein |
| KW-0518 | Myosin |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-1185 | Reference proteome |
| KW-0832 | Ubl conjugation |