Gene: ALDH1A3

Basic information

Tag Content
Uniprot ID A0A452FFP9
Entrez ID 102179885
Genbank protein ID
Genbank nucleotide ID XM_018066420.1
Ensembl protein ID ENSCHIP00000023000
Ensembl nucleotide ID ENSCHIG00000020729
Gene name Aldedh domain-containing protein
Gene symbol ALDH1A3
Organism Capra hircus
NCBI taxa ID 9925
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MATTNGAVEN GQPDRKAPAL PRPVRNLEVQ FTKIFINNEW NESKSGKKFA TYNPSTLEKI 60
CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDAPSRGRLL QQLADLVERD RAVLATLETM 120
DTGKPFLHAF FIDLEGCIKT LRYFAGWADK IQGRTIPTDD NVVCFTRHEP IGVCGAITPW 180
NFPLLMLVWK LAPALCCGNT VVLKPAEQTP LTALYLGSLI KEVGFPPGVV NIVPGFGPTV 240
GAAISSHPQI NKIAFTGSTE VGKLVKEAAS HSNLKRVTLE LGGKNPCIVC ADADLSLAVE 300
CAHQGVFFNQ GQCCTAASRV FVEEQIYEEF VRQSVEYAKK RPVGDPFDVR TEQGPQIDQK 360
QFDKILDLIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSE VTDTMRIAKE EIFGPVQPIL 420
KFKNIEEVIK RANSLEYGLT AAVFTKNLDK ALKLASALES GTVWINCYNA IYAQAPFGGF 480
KMSGNGRELG EYALAEYTEV KTVTIKLDDK DP 512

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologALDH1A3100856346E2R543Canis lupus familiarisPredictionMore>>
1:1 orthologALDH1A3102179885A0A452FFP9Capra hircusPredictionMore>>
1:1 orthologALDH1A3100057072F6Y0Q6Equus caballusPredictionMore>>
1:1 orthologALDH1A3220P47895Homo sapiensPredictionMore>>
1:1 orthologAldh1a356847Q9JHW9CPO,CLOMus musculusPublicationMore>>
1:1 orthologALDH1A3453686H2QA58Pan troglodytesPredictionMore>>
1:1 orthologALDH1A3A0A480JMD7Sus scrofaPredictionMore>>
1:1 orthologG1SU45Oryctolagus cuniculusPredictionMore>>
1:1 orthologAldh1a3A0A0G2JUS6Rattus norvegicusPredictionMore>>
1:1 orthologaldh1a3751785Q0H2G3Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005737 cytoplasm
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0070403 NAD+ binding
GO:0042803 protein homodimerization activity
GO:0001758 retinal dehydrogenase activity
GO:0070324 thyroid hormone binding
GO:0060324 face development
GO:0070384 Harderian gland development
GO:0042472 inner ear morphogenesis
GO:0007626 locomotory behavior
GO:0050885 neuromuscular process controlling balance
GO:0021768 nucleus accumbens development
GO:0060166 olfactory pit development
GO:0002072 optic cup morphogenesis involved in camera-type eye development
GO:0043065 positive regulation of apoptotic process
GO:0051289 protein homotetramerization
GO:0042574 retinal metabolic process
GO:0002138 retinoic acid biosynthetic process
GO:0060013 righting reflex

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0560 Oxidoreductase
KW-1185 Reference proteome

Interpro

InterPro ID InterPro Term
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom

PROSITE

PROSITE ID PROSITE Term
PS00070 ALDEHYDE_DEHYDR_CYS
PS00687 ALDEHYDE_DEHYDR_GLU

Pfam

Pfam ID Pfam Term
PF00171 Aldedh