| Tag | Content |
|---|---|
| Uniprot ID | Q9JHW9; Q9EQP7; Q9JI72; |
| Entrez ID | 56847 |
| Genbank protein ID | AAH58277.1; AAF67736.1; AAG38488.1; AAG33935.1; AAF86980.1; |
| Genbank nucleotide ID | NM_053080.3 |
| Ensembl protein ID | ENSMUSP00000015278 |
| Ensembl nucleotide ID | ENSMUSG00000015134 |
| Gene name | Aldehyde dehydrogenase family 1 member A3 |
| Gene symbol | Aldh1a3 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO,CLO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 17184764 |
| Functional description | NAD-dependent aldehyde dehydrogenase that catalyzes the formation of retinoic acid (PubMed:11044606, PubMed:11013254, PubMed:14623956). Has high activity with all-trans retinal, and has much lower in vitro activity with acetaldehyde (By similarity). Required for the biosynthesis of normal levels of retinoic acid in the embryonic ocular and nasal regions; retinoic acid is required for normal embryonic development of the eye and the nasal region (PubMed:14623956). |
| Sequence | MATTNGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HESKSGRKFA TYNPSTLEKI 60 CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL HQLADLVERD RAILATLETM 120 DTGKPFLHAF FVDLEGCIKT FRYFAGWADK IQGRTIPTDD NVVCFTRHEP IGVCGAITPW 180 NFPLLMLAWK LAPALCCGNT VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV 240 GAAISSHPQI NKIAFTGSTE VGKLVREAAS RSNLKRVTLE LGGKNPCIVC ADADLDLAVE 300 CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK TEQGPQIDQK 360 QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD VTDNMRIAKE EIFGPVQPIL 420 KFKNLEEVIK RANSTDYGLT AAVFTKNLDK ALKLAAALES GTVWINCYNA FYAQAPFGGF 480 KMSGNGRELG EYALAEYTEV KTVTIKLEEK NP 512 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ALDH1A3 | 100856346 | E2R543 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ALDH1A3 | 102179885 | A0A452FFP9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | ALDH1A3 | 100057072 | F6Y0Q6 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | ALDH1A3 | 220 | P47895 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Aldh1a3 | 56847 | Q9JHW9 | CPO,CLO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ALDH1A3 | 453686 | H2QA58 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | ALDH1A3 | A0A480JMD7 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | G1SU45 | Oryctolagus cuniculus | Prediction | More>> | ||||
| 1:1 ortholog | Aldh1a3 | A0A0G2JUS6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | aldh1a3 | 751785 | Q0H2G3 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001758 | retinal dehydrogenase activity | ISS |
| GO:0001758 | retinal dehydrogenase activity | ISO |
| GO:0004028 | 3-chloroallyl aldehyde dehydrogenase activity | TAS |
| GO:0004029 | aldehyde dehydrogenase (NAD+) activity | IDA |
| GO:0004029 | aldehyde dehydrogenase (NAD+) activity | IBA |
| GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | ISO |
| GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity | IDA |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0070324 | thyroid hormone binding | IPI |
| GO:0070403 | NAD+ binding | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0002072 | optic cup morphogenesis involved in camera-type eye development | IGI |
| GO:0002138 | retinoic acid biosynthetic process | ISO |
| GO:0002138 | retinoic acid biosynthetic process | IDA |
| GO:0002138 | retinoic acid biosynthetic process | IMP |
| GO:0007626 | locomotory behavior | IMP |
| GO:0021768 | nucleus accumbens development | IMP |
| GO:0031076 | embryonic camera-type eye development | IMP |
| GO:0031076 | embryonic camera-type eye development | IGI |
| GO:0042472 | inner ear morphogenesis | IMP |
| GO:0042572 | retinol metabolic process | IEA |
| GO:0042573 | retinoic acid metabolic process | ISO |
| GO:0042573 | retinoic acid metabolic process | IGI |
| GO:0042573 | retinoic acid metabolic process | IMP |
| GO:0042574 | retinal metabolic process | ISO |
| GO:0043065 | positive regulation of apoptotic process | IGI |
| GO:0043065 | positive regulation of apoptotic process | IMP |
| GO:0043584 | nose development | IMP |
| GO:0048048 | embryonic eye morphogenesis | IGI |
| GO:0048048 | embryonic eye morphogenesis | IMP |
| GO:0048386 | positive regulation of retinoic acid receptor signaling pathway | ISO |
| GO:0050885 | neuromuscular process controlling balance | IMP |
| GO:0051289 | protein homotetramerization | ISS |
| GO:0051289 | protein homotetramerization | ISO |
| GO:0055114 | oxidation-reduction process | IEA |
| GO:0060013 | righting reflex | IMP |
| GO:0060166 | olfactory pit development | IMP |
| GO:0060324 | face development | IGI |
| GO:0070384 | Harderian gland development | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-5362517 | Signaling by Retinoic Acid | IEA |
| R-MMU-5365859 | RA biosynthesis pathway | IEA |
| R-MMU-9006931 | Signaling by Nuclear Receptors | IEA |
| Pfam ID | Pfam Term |
|---|---|
| PF00171 | Aldedh |