| Tag | Content |
|---|---|
| Uniprot ID | A0A5F4CSF2 |
| Entrez ID | 442860 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005628197.2; XM_005628196.2; XM_532374.5; XM_014118807.1; |
| Ensembl protein ID | ENSCAFP00000055722 |
| Ensembl nucleotide ID | ENSCAFG00000002057 |
| Gene name | Platelet-derived growth factor receptor alpha |
| Gene symbol | PDGFRA |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. |
| Sequence | MGTSLLALLI LGCLLAGPSL ILCQLSLPSI LPNENEKVVQ LNSSFSLRCF GESEVSWHYP 60 TSEEENPNVE IRNEENNSGL FVTVLEVVNA SAAHTGLYTC YYNHTQTDEN EIEGRHIYIY 120 VPDPDVAFVP LGMTDYLVIV EDDDSAIIPC RTTDPETPVT LLSNDGVVHA SYDSRQGFNG 180 TFSVGPYICE ATVRGKKFQT IPFNVYALKA TSELDLEMEA LKTVYKSGET IVVTCAVFNN 240 EVVDLQWTYP GEVKGKGITM LEEIKVPSIK LVYTLRVPEA TVKDSGDYEC AARQATKEVK 300 EMKKVTISVH EKGFIEIKPN FSQLEAVDLH EVKHFVVDVQ AYPPPRISWL KDNLTLIENL 360 TEITTDIERT QEIRYRSKLK LIRAKEEDSG HYTIVVQNED DVKSYTFELL TQVPSSILDL 420 VDDHHGSTGG QTVRCIAEGT PLPDIEWMIC KDIKKCNNET SWAILANNIS NIITEVHPRD 480 RSTVEGRVTF TRVEETIAVR CLAKNLLGAE SRELKLVAPT LRSELTVAAA VLVLLVIVII 540 SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600 SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660 LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSRHPEK PKKELDIFGL NPADDSTRSY 720 VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 780 LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840 RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900 VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWHSEPEKR PSFYHLSEIV ENLLPGQYKK 960 SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGSLDEQ RLSADSGYII 1020 PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080 SDLVEDSFL 1089 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRA | 282301 | F1MX49 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 442860 | A0A5F4CSF2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 102174007 | A0A452DR61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 100059815 | F7A2X2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 5156 | P16234 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfra | 18595 | P26618 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFRA | 461318 | H2QPH4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | A0A287AYB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pdgfra | 25267 | G3V6A0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0005524 | ATP binding |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity |
| GO:0006935 | chemotaxis |
| GO:0007275 | multicellular organism development |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0175 | Coiled coil |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR027290 | PDGFRA |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |