| Tag | Content |
|---|---|
| Uniprot ID | H2QPH4 |
| Entrez ID | 461318 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_016951726.1 |
| Ensembl protein ID | ENSPTRP00000027635 |
| Ensembl nucleotide ID | ENSPTRG00000016066 |
| Gene name | Platelet-derived growth factor receptor alpha |
| Gene symbol | PDGFRA |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. |
| Sequence | MGFAETIRKF PRAMGTSHPA FLVLSCLLTG LSLILCQLSL PSILPNENEK VVQLNSSFSL 60 RCFGESEVSW QYPMSEEESS DVEIRNEENN SGLFVTVLEV SSASAAHTGL YTCYYNHTQT 120 EENELEGRHI YIYVPDPDVA FVPLGMTDYL VIVEDDDSAI IPCRTTDPET PVTLHNSEGV 180 VPASYNSRQG FNGTFTVGPY ICEATVKGKK FQTIPFNVYA LKATSELDLE MEALKTVYKS 240 GETIVVTCAV FNNEVVDLQW TYPGEVKGKG ITMLEEIKVP SIKLVYTLTV PEATVKDSGD 300 YECAARQATR EVKEMKKVTI SVHEKGFIEI KPTFSQLEAV NLHEVKHFVV EVRAYPPPRI 360 SWLKNNLTLI ENLTEITTDV EKIQEIRYRS KLKLIRAKEE DSGHYTIVAQ NEDAVKSYTF 420 ELLTQVPSSI LDLVDDHHGS TGGQTVRCTA EGTPLPDIEW MICKDIKKCN NETSWTILAN 480 NVSNIITEIH PRDRSTVEGR VTFAKVEETI AVRCLAKNLL GAENRELKLV APTLRSELTV 540 AAAVLVLLVI VIISLIVLVV IWKQKPRYEI RWRVIESISP DGHEYIYVDP MQLPYDSRWE 600 FPRDGLVLGR VLGSGAFGKV VEGTAYGLSR SQPVMKVAVK MLKPTARSSE KQALMSELKI 660 MTHLGPHLNI VNLLGACTKS GPIYIITEYC FYGDLVNYLH KNRDSFLSHH PEKPKKELDI 720 FGLNPADEST RSYVILSFEN NGDYMDMKQA DTTQYVPMLE RKEVSKYSDI QRSLYDRPAS 780 YKKKSMLDSE VKNLLSDDNS EGLTLLDLLS FTYQVARGME FLASKNCVHR DLAARNVLLA 840 QGKIVKICDF GLARDIMHDS NYVSKGSTFL PVKWMAPESI FDNLYTTLSD VWSYGILLWE 900 IFSLGGTPYP GMMVDSTFYN KIKSGYRMAK PDHATSEVYE IMVKCWNSEP EKRPSFYHLS 960 EIVENLLPGQ YKKSYEKIHL DFLKSDHPAV ARMRVDSDNA YIGVTYKNEE DKLKDWEGGL 1020 DEQRLSADSG YIIPLPDIDP VPEEEDLGKR NRHSSQTSEE SAIETGSSSS TFIKREDETI 1080 EDIDMMDDIG IDSSDLVEDS FL 1102 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRA | 282301 | F1MX49 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 442860 | A0A5F4CSF2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 102174007 | A0A452DR61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 100059815 | F7A2X2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 5156 | P16234 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfra | 18595 | P26618 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFRA | 461318 | H2QPH4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | A0A287AYB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pdgfra | 25267 | G3V6A0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0030054 | cell junction |
| GO:0005929 | cilium |
| GO:0009897 | external side of plasma membrane |
| GO:0005794 | Golgi apparatus |
| GO:0005887 | integral component of plasma membrane |
| GO:0005902 | microvillus |
| GO:0005654 | nucleoplasm |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0019838 | growth factor binding |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0005161 | platelet-derived growth factor receptor binding |
| GO:0042803 | protein homodimerization activity |
| GO:0044877 | protein-containing complex binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0038085 | vascular endothelial growth factor binding |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| GO:0030325 | adrenal gland development |
| GO:0055003 | cardiac myofibril assembly |
| GO:0060326 | cell chemotaxis |
| GO:0071230 | cellular response to amino acid stimulus |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0008210 | estrogen metabolic process |
| GO:0030198 | extracellular matrix organization |
| GO:0060325 | face morphogenesis |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0001701 | in utero embryonic development |
| GO:0033327 | Leydig cell differentiation |
| GO:0030324 | lung development |
| GO:0001553 | luteinization |
| GO:0030539 | male genitalia development |
| GO:0072277 | metanephric glomerular capillary formation |
| GO:0007275 | multicellular organism development |
| GO:0010544 | negative regulation of platelet activation |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0048015 | phosphatidylinositol-mediated signaling |
| GO:0070527 | platelet aggregation |
| GO:0030335 | positive regulation of cell migration |
| GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:0033674 | positive regulation of kinase activity |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| GO:0010863 | positive regulation of phospholipase C activity |
| GO:0046777 | protein autophosphorylation |
| GO:0050920 | regulation of chemotaxis |
| GO:2000739 | regulation of mesenchymal stem cell differentiation |
| GO:0061298 | retina vasculature development in camera-type eye |
| GO:0060021 | roof of mouth development |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR027290 | PDGFRA |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |