| Tag | Content |
|---|---|
| Uniprot ID | F1MX49 |
| Entrez ID | 282301 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001192345.2; XM_010806122.2; XM_005207944.3; |
| Ensembl protein ID | ENSBTAP00000009441 |
| Ensembl nucleotide ID | ENSBTAG00000007173 |
| Gene name | Platelet-derived growth factor receptor alpha |
| Gene symbol | PDGFRA |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. |
| Sequence | MGTSHWALLV LGCLFTGPSL ILCQLSLPSI LPNENERVVQ LNSSFSLRCF GESEVSWQYP 60 MSEEEYPDVE IRNEENNSGL FVTVLEVVSA SAAHTGLYTC YYNHTQMDEN EIEGRHIYIY 120 VPDPDVAFVP LGMTDSLVIV EDEDSVIIPC RTTDPETPVT LLSSEGIVPA SYDSRQGFKG 180 TFSVGLYICE ATVRGKKFQT IPFNVYAYTA TSKLDLEMES PKTVYKAGES IVVTCTVFNN 240 EVVDFQWTYP GQMKGKGITR LEETKFPSIK LVYTLRVPEA TVKDSGDYEC AAHQATKEVK 300 KMRNVTISVH EKGFIEIKPN FNLLEAVNLH EVKHFVVDVQ AYPPPKITWL KDNLTLIENL 360 TEITTDIEKI QEISYRSKLK LIRAKEEDSG HYTIVVQNED DVKSYTFELL TQVPSSILDL 420 VDDHHGSNGG QTVRCTAEGT PLPDIEWMVC KDIKKCNNET SWTVLANNVS NIITGVHPRD 480 RSTVEGQVTF AKVEETIAVR CLAKNLLGVE SRELKLVAPT LRSELTVAAA VLVLLVIVII 540 SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600 SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660 LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFLSHHPEK PKKELDIFGL NPADESTRSY 720 VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRA LYDRPASYKK KSMLDSEVKN 780 LLSDDNSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840 RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900 VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV KCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 960 SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020 PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080 SDLVEDSFL 1089 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRA | 282301 | F1MX49 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 442860 | A0A5F4CSF2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 102174007 | A0A452DR61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 100059815 | F7A2X2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 5156 | P16234 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfra | 18595 | P26618 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFRA | 461318 | H2QPH4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | A0A287AYB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pdgfra | 25267 | G3V6A0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0019838 | growth factor binding |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity |
| GO:0006935 | chemotaxis |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0007275 | multicellular organism development |
| GO:0033674 | positive regulation of kinase activity |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR027290 | PDGFRA |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |