| Tag | Content |
|---|---|
| Uniprot ID | P26618; Q3TQ37; Q62046; Q7TSJ3; Q8C4N3; |
| Entrez ID | 18595 |
| Genbank protein ID | BAC38283.1; AAA39904.1; AAA39733.1; BAE23004.1; BAE27808.1; BAE37548.1; AAH53036.1; |
| Genbank nucleotide ID | NM_011058.3; NM_001083316.2; NM_001347718.1; XM_006504262.3; NM_001347719.1; XM_006504263.3; XM_006504261.3; |
| Ensembl protein ID | ENSMUSP00000143891; ENSMUSP00000000476; ENSMUSP00000143906; ENSMUSP00000127173; |
| Ensembl nucleotide ID | ENSMUSG00000029231 |
| Gene name | Platelet-derived growth factor receptor alpha |
| Gene symbol | Pdgfra |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E12.5, E13.5, E14.5 |
| Data sources | Manually collected |
| Reference | 27856617; 17143286; 9226440; 12490557; 26250625; 17499702; 11782318; |
| Functional description | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor. |
| Sequence | MGTSHQVFLV LSCLLTGPGL ISCQLLLPSI LPNENEKIVQ LNSSFSLRCV GESEVSWQHP 60 MSEEDDPNVE IRSEENNSGL FVTVLEVVNA SAAHTGWYTC YYNHTQTDES EIEGRHIYIY 120 VPDPDMAFVP LGMTDSLVIV EEDDSAIIPC RTTDPETQVT LHNNGRLVPA SYDSRQGFNG 180 TFSVGPYICE ATVKGRTFKT SEFNVYALKA TSELNLEMDA RQTVYKAGET IVVTCAVFNN 240 EVVDLQWTYP GEVRNKGITM LEEIKLPSIK LVYTLTVPKA TVKDSGEYEC AARQATKEVK 300 EMKRVTISVH EKGFVEIEPT FGQLEAVNLH EVREFVVEVQ AYPTPRISWL KDNLTLIENL 360 TEITTDVQKS QETRYQSKLK LIRAKEEDSG HYTIIVQNED DVKSYTFELS TLVPASILDL 420 VDDHHGSGGG QTVRCTAEGT PLPEIDWMIC KHIKKCNNDT SWTVLASNVS NIITELPRRG 480 RSTVEGRVSF AKVEETIAVR CLAKNNLSVV ARELKLVAPT LRSELTVAAA VLVLLVIVIV 540 SLIVLVVIWK QKPRYEIRWR VIESISPDGH EYIYVDPMQL PYDSRWEFPR DGLVLGRILG 600 SGAFGKVVEG TAYGLSRSQP VMKVAVKMLK PTARSSEKQA LMSELKIMTH LGPHLNIVNL 660 LGACTKSGPI YIITEYCFYG DLVNYLHKNR DSFMSQHPEK PKKDLDIFGL NPADESTRSY 720 VILSFENNGD YMDMKQADTT QYVPMLERKE VSKYSDIQRS LYDRPASYKK KSMLDSEVKN 780 LLSDDDSEGL TLLDLLSFTY QVARGMEFLA SKNCVHRDLA ARNVLLAQGK IVKICDFGLA 840 RDIMHDSNYV SKGSTFLPVK WMAPESIFDN LYTTLSDVWS YGILLWEIFS LGGTPYPGMM 900 VDSTFYNKIK SGYRMAKPDH ATSEVYEIMV QCWNSEPEKR PSFYHLSEIV ENLLPGQYKK 960 SYEKIHLDFL KSDHPAVARM RVDSDNAYIG VTYKNEEDKL KDWEGGLDEQ RLSADSGYII 1020 PLPDIDPVPE EEDLGKRNRH SSQTSEESAI ETGSSSSTFI KREDETIEDI DMMDDIGIDS 1080 SDLVEDSFL 1089 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRA | 282301 | F1MX49 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 442860 | A0A5F4CSF2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 102174007 | A0A452DR61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 100059815 | F7A2X2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 5156 | P16234 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfra | 18595 | P26618 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFRA | 461318 | H2QPH4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | A0A287AYB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pdgfra | 25267 | G3V6A0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004672 | protein kinase activity | ISO |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | ISO |
| GO:0004714 | transmembrane receptor protein tyrosine kinase activity | IBA |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity | ISS |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity | ISO |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity | IDA |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity | IBA |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity | ISS |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity | ISO |
| GO:0005161 | platelet-derived growth factor receptor binding | ISO |
| GO:0005524 | ATP binding | IEA |
| GO:0019838 | growth factor binding | IBA |
| GO:0038085 | vascular endothelial growth factor binding | ISO |
| GO:0042803 | protein homodimerization activity | ISS |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0043548 | phosphatidylinositol 3-kinase binding | ISO |
| GO:0044877 | protein-containing complex binding | IDA |
| GO:0048407 | platelet-derived growth factor binding | ISO |
| GO:0048407 | platelet-derived growth factor binding | IDA |
| GO:0048407 | platelet-derived growth factor binding | TAS |
| GO:0048407 | platelet-derived growth factor binding | IBA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001553 | luteinization | IGI |
| GO:0001553 | luteinization | IMP |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0002244 | hematopoietic progenitor cell differentiation | IBA |
| GO:0002244 | hematopoietic progenitor cell differentiation | IMP |
| GO:0007169 | transmembrane receptor protein tyrosine kinase signaling pathway | IBA |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | ISS |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration | ISO |
| GO:0007275 | multicellular organism development | IBA |
| GO:0008210 | estrogen metabolic process | IGI |
| GO:0008284 | positive regulation of cell population proliferation | ISS |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0008585 | female gonad development | IGI |
| GO:0009653 | anatomical structure morphogenesis | IMP |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0010544 | negative regulation of platelet activation | ISS |
| GO:0010544 | negative regulation of platelet activation | ISO |
| GO:0010863 | positive regulation of phospholipase C activity | ISO |
| GO:0016477 | cell migration | IMP |
| GO:0018108 | peptidyl-tyrosine phosphorylation | ISS |
| GO:0018108 | peptidyl-tyrosine phosphorylation | ISO |
| GO:0018108 | peptidyl-tyrosine phosphorylation | IDA |
| GO:0023019 | signal transduction involved in regulation of gene expression | IDA |
| GO:0030198 | extracellular matrix organization | IMP |
| GO:0030324 | lung development | IMP |
| GO:0030325 | adrenal gland development | IGI |
| GO:0030335 | positive regulation of cell migration | ISS |
| GO:0030335 | positive regulation of cell migration | ISO |
| GO:0030539 | male genitalia development | IMP |
| GO:0033327 | Leydig cell differentiation | IMP |
| GO:0033674 | positive regulation of kinase activity | IBA |
| GO:0034614 | cellular response to reactive oxygen species | ISO |
| GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway | ISO |
| GO:0035790 | platelet-derived growth factor receptor-alpha signaling pathway | IDA |
| GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | ISS |
| GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway | ISO |
| GO:0042060 | wound healing | IMP |
| GO:0042475 | odontogenesis of dentin-containing tooth | IMP |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | ISS |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity | ISO |
| GO:0046777 | protein autophosphorylation | ISS |
| GO:0046777 | protein autophosphorylation | ISO |
| GO:0046777 | protein autophosphorylation | IDA |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | ISO |
| GO:0048008 | platelet-derived growth factor receptor signaling pathway | IMP |
| GO:0048015 | phosphatidylinositol-mediated signaling | ISS |
| GO:0048015 | phosphatidylinositol-mediated signaling | ISO |
| GO:0048146 | positive regulation of fibroblast proliferation | ISS |
| GO:0048146 | positive regulation of fibroblast proliferation | ISO |
| GO:0048557 | embryonic digestive tract morphogenesis | IMP |
| GO:0048701 | embryonic cranial skeleton morphogenesis | IMP |
| GO:0048705 | skeletal system morphogenesis | IMP |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | ISO |
| GO:0050920 | regulation of chemotaxis | ISO |
| GO:0055003 | cardiac myofibril assembly | IGI |
| GO:0060021 | roof of mouth development | IMP |
| GO:0060325 | face morphogenesis | IMP |
| GO:0060326 | cell chemotaxis | ISO |
| GO:0060326 | cell chemotaxis | IMP |
| GO:0060437 | lung growth | ISO |
| GO:0061047 | positive regulation of branching involved in lung morphogenesis | ISO |
| GO:0061298 | retina vasculature development in camera-type eye | IGI |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISS |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade | ISO |
| GO:0070527 | platelet aggregation | ISS |
| GO:0070527 | platelet aggregation | ISO |
| GO:0071230 | cellular response to amino acid stimulus | IDA |
| GO:0072277 | metanephric glomerular capillary formation | IGI |
| GO:2000739 | regulation of mesenchymal stem cell differentiation | ISS |
| GO:2000739 | regulation of mesenchymal stem cell differentiation | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005623 | cell | IEA |
| GO:0005634 | nucleus | ISS |
| GO:0005634 | nucleus | ISO |
| GO:0005634 | nucleus | IDA |
| GO:0005654 | nucleoplasm | ISO |
| GO:0005737 | cytoplasm | ISS |
| GO:0005737 | cytoplasm | ISO |
| GO:0005737 | cytoplasm | IDA |
| GO:0005794 | Golgi apparatus | IDA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | ISS |
| GO:0005887 | integral component of plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | IBA |
| GO:0005902 | microvillus | IDA |
| GO:0005929 | cilium | IDA |
| GO:0009897 | external side of plasma membrane | IDA |
| GO:0009986 | cell surface | IDA |
| GO:0030054 | cell junction | ISO |
| GO:0030424 | axon | ISO |
| GO:0031226 | intrinsic component of plasma membrane | ISO |
| GO:0032991 | protein-containing complex | ISO |
| GO:0043235 | receptor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1257604 | PIP3 activates AKT signaling | IEA |
| R-MMU-1280215 | Cytokine Signaling in Immune system | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-186763 | Downstream signal transduction | IEA |
| R-MMU-186797 | Signaling by PDGF | IEA |
| R-MMU-199418 | Negative regulation of the PI3K/AKT network | IEA |
| R-MMU-5673001 | RAF/MAP kinase cascade | IEA |
| R-MMU-5683057 | MAPK family signaling cascades | IEA |
| R-MMU-5684996 | MAPK1/MAPK3 signaling | IEA |
| R-MMU-6811558 | PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling | IEA |
| R-MMU-9006925 | Intracellular signaling by second messengers | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| R-MMU-9607240 | FLT3 Signaling | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0966 | Cell projection |
| KW-0145 | Chemotaxis |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-0597 | Phosphoprotein |
| KW-0656 | Proto-oncogene |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| KW-0832 | Ubl conjugation |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR027290 | PDGFRA |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |