| Tag | Content |
|---|---|
| Uniprot ID | G3V6A0 |
| Entrez ID | 25267 |
| Genbank protein ID | EDL89926.1 |
| Genbank nucleotide ID | XM_006250881.3; XM_006250880.3; NM_012802.1; XM_006250879.3; |
| Ensembl protein ID | ENSRNOP00000003077 |
| Ensembl nucleotide ID | ENSRNOG00000002244 |
| Gene name | Platelet-derived growth factor receptor alpha |
| Gene symbol | Pdgfra |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. |
| Sequence | MGTSQAFLVL SCLLTGPSLI VCQLLLPSIL PNENEKIVPL SSSFSLRCFG ESEVSWQHPM 60 SEEEDPNVEI RTEENNSSLF VTVLEVVNAS AAHTGWYTCY YNHTQTEESE IEGRHIYIYV 120 PDPDMAFVPL GMTDSLVIVE EDDSAIIPCR TTDPDTEVTL HNNGRLVPAS YDSRQGFNGT 180 FSVGPYICEA TVRGRTFKTS EFNVYALKAT SELNLEMDTR QTVYKAGETI VVTCAVFNNE 240 VVDLQWTYPG EVRNKGITML EEIKLPSIKL VYTLTVPKAT VKDSGDYECA ARQATKEVKE 300 MKTVTISVHE KGFVQIRPTF GHLETVNLHQ VREFVVEVQA YPTPRISWLK DNLTLIENLT 360 EITTDVQRSQ ETRYQSKLKL IRAKEEDSGH YTIIVQNDDD MKSYTFELST LVPASILELV 420 DDHHGSGGGQ TVRCTAEGTP LPNIEWMICK DIKKCNNDTS WTVLASNVSN IITEFHQRGR 480 STVEGRVSFA KVEETIAVRC LAKNDLGIGN RELKLVAPTL RSELTVAAAV LVLLVIVIVS 540 LIVLVVIWKQ KPRYEIRWRV IESISPDGHE YIYVDPMQLP YDSRWEFPRD GLVLGRILGS 600 GAFGKVVEGT AYGLSRSQPV MKVAVKMLKP TARSSEKQAL MSELKIMTHL GPHLNIVNLL 660 GACTKSGPIY IITEYCFYGD LVNYLHKNRD SFMSRHPEKP KKDLDIFGLN PADESTRSYV 720 ILSFENNGDY VDMKQADTTQ YVPMLERKEV SKYSDIQRSL YDRPASYKKK SMLDSEAKNL 780 LSDDDSEGLT LLDLLSFTYQ VARGMEFLAS KNCVHRDLAA RNVLLAQGKI VKICDFGLAR 840 DIMHDSNYVS KGSTFLPVKW MAPESIFDNL YTTLSDVWSY GVLLWEIFSL GGTPYPGMMV 900 DSTFYNKIKS GYRMAKPDHA TSEVYEIMVQ CWNSEPEKRP SFYHLSEIVE NLLPGQYKKS 960 YEKIHLDFLK SDHPAVARMR VDSDNAYIGV TYKNEEDKLK EWEGGLDEQR LSADSGYIIP 1020 LPDIDPVPEE EDLGKRNRHS SQTSEESAIE TGSSSSTFIK REDETIEDID MMDDIGIDSS 1080 DLVEDSFL 1088 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | PDGFRA | 282301 | F1MX49 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 442860 | A0A5F4CSF2 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 102174007 | A0A452DR61 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 100059815 | F7A2X2 | Equus caballus | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | 5156 | P16234 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Pdgfra | 18595 | P26618 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | PDGFRA | 461318 | H2QPH4 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | PDGFRA | A0A287AYB4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Pdgfra | 25267 | G3V6A0 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0030054 | cell junction |
| GO:0005929 | cilium |
| GO:0009897 | external side of plasma membrane |
| GO:0005794 | Golgi apparatus |
| GO:0005887 | integral component of plasma membrane |
| GO:0005902 | microvillus |
| GO:0005654 | nucleoplasm |
| GO:0032991 | protein-containing complex |
| GO:0005524 | ATP binding |
| GO:0005018 | platelet-derived growth factor alpha-receptor activity |
| GO:0048407 | platelet-derived growth factor binding |
| GO:0005161 | platelet-derived growth factor receptor binding |
| GO:0042803 | protein homodimerization activity |
| GO:0044877 | protein-containing complex binding |
| GO:0038085 | vascular endothelial growth factor binding |
| GO:0005021 | vascular endothelial growth factor-activated receptor activity |
| GO:0030325 | adrenal gland development |
| GO:0055003 | cardiac myofibril assembly |
| GO:0060326 | cell chemotaxis |
| GO:0071230 | cellular response to amino acid stimulus |
| GO:0034614 | cellular response to reactive oxygen species |
| GO:0048701 | embryonic cranial skeleton morphogenesis |
| GO:0048557 | embryonic digestive tract morphogenesis |
| GO:0008210 | estrogen metabolic process |
| GO:0030198 | extracellular matrix organization |
| GO:0060325 | face morphogenesis |
| GO:0002244 | hematopoietic progenitor cell differentiation |
| GO:0001701 | in utero embryonic development |
| GO:0033327 | Leydig cell differentiation |
| GO:0030324 | lung development |
| GO:0001553 | luteinization |
| GO:0030539 | male genitalia development |
| GO:0072277 | metanephric glomerular capillary formation |
| GO:0010544 | negative regulation of platelet activation |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0048015 | phosphatidylinositol-mediated signaling |
| GO:0070527 | platelet aggregation |
| GO:0030335 | positive regulation of cell migration |
| GO:0038091 | positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0048146 | positive regulation of fibroblast proliferation |
| GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity |
| GO:0010863 | positive regulation of phospholipase C activity |
| GO:0046777 | protein autophosphorylation |
| GO:0050920 | regulation of chemotaxis |
| GO:2000739 | regulation of mesenchymal stem cell differentiation |
| GO:0061298 | retina vasculature development in camera-type eye |
| GO:0060021 | roof of mouth development |
| GO:0023019 | signal transduction involved in regulation of gene expression |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0145 | Chemotaxis |
| KW-0217 | Developmental protein |
| KW-1015 | Disulfide bond |
| KW-0393 | Immunoglobulin domain |
| KW-0418 | Kinase |
| KW-0472 | Membrane |
| KW-0547 | Nucleotide-binding |
| KW-1267 | Proteomics identification |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0829 | Tyrosine-protein kinase |
| InterPro ID | InterPro Term |
|---|---|
| IPR007110 | Ig-like_dom |
| IPR036179 | Ig-like_dom_sf |
| IPR013783 | Ig-like_fold |
| IPR013098 | Ig_I-set |
| IPR003599 | Ig_sub |
| IPR003598 | Ig_sub2 |
| IPR011009 | Kinase-like_dom_sf |
| IPR027290 | PDGFRA |
| IPR000719 | Prot_kinase_dom |
| IPR017441 | Protein_kinase_ATP_BS |
| IPR001245 | Ser-Thr/Tyr_kinase_cat_dom |
| IPR008266 | Tyr_kinase_AS |
| IPR020635 | Tyr_kinase_cat_dom |
| IPR001824 | Tyr_kinase_rcpt_3_CS |