| Tag | Content |
|---|---|
| Uniprot ID | A0A5F5PRN6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_014738600.1 |
| Ensembl protein ID | ENSECAP00000050921 |
| Ensembl nucleotide ID | ENSECAG00000011661 |
| Gene name | Nuclear receptor binding SET domain protein 2 |
| Gene symbol | NSD2 |
| Organism | Equus caballus |
| NCBI taxa ID | 9796 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEFSIKKNPL SVQKVVKCIK MKQAPEILGN TNGKTQNCEV NRECSVFLSK AQLSTSLQEG 60 VMQKFNGHDA LPFIPTEKLK DLTSRVFNGE PGAHDARLRF ESQEMKGIGT PPNTTPIKNG 120 SPEIKLKITK TYMNGKPLFE SSICGDGAAT VSQSEENGQK PENKARRNRK RSIKYDSLLE 180 QGLVEAALVS KISGPSDKKI PAKKESCPST GKDKDHLLKY NVGDLVWSKV SGYPWWPCMV 240 SADPLLHSYT KLKGQKKSAR QYHVQFFGDA PERAWIFEKS LVTFEGEGQF EKLCQESAKQ 300 APTKAEKIKL LKPISGKLRA QWEMGIVQAE EAASMSVEER KAKFTFLYVG DQLRLNPHVA 360 KEAGIAVESL GEMVESSGVT EEAAYNSKPM REEGIPIKRR RRAKLPSSAE NQESDPGTVK 420 TTPQKTAEGD SKRGVGSPSG RKKATASTPR SRKGDAASQF LVFCQKHRDE VVAEHPDASS 480 EEIEELLGSQ WNMLNEKQKA RYNTKFALVA SSQSEEDSGN LNGKKRNHTK RTQDPTEDVE 540 VEDAPRKRLR TDKQGLRKRE MITDKTARTS SCKAIEAASS LKSQAATKHL SDACKPLKKR 600 NRASAAASSA LAFSKSSSPS ASLTENEVSD GQGDEPLESP YESADETQTE VSVSSKKSER 660 GVTAKKEYVC QLCEKTGSLV LCEGPCCGAF HLACLGLSRR PEGRFTCSEC ASGIHTCFVC 720 KENKTDVKRC VVSQCGKFYH EACVRKYPLT VFESRGFRCP LHSCVSCHAS NPSNPRPSKG 780 KMMRCVRCPV AYHGGDACLA AGCSVIASNS IICTGHFTAR KGKRHHAHVN VSWCFVCSKG 840 GSLLCCESCP AAFHPDCLNI EMPDGSWFCN DCRAGKKLHF QDIIWVKLGN YRWWPAEVCH 900 PKNVPPNIQK MKHEIGEFPV FFFGSKDYYW THQARVFPYM EGDRGSRYQG VRGIGRVFKN 960 ALQEAEARFR EIKLQREARE TQENERKPPP YKHIKVNKPY GKVQIYTADI SEIPKCNCKP 1020 TDENPCGFDS ECLNRMLMFE CHPQVCPAGE YCQNQCFTKR QYPETKIIKT DGKGWGLVAK 1080 RDIRKGEFVN EYVGELIDEE ECMARIKYAH ENDITHFYML TIDKDRIIDA GPKGNYSRFM 1140 NHSCQPNCET LKWTVNGDTR VGLFAVCDIP AGTELTFNYN LDCLGNEKTV CRCGASNCSG 1200 FLGDRPKTST SLSSEEKGKK TKKKTRRRRT KGEGKKKSED ECFRCGDGGQ LVLCDRKFCT 1260 KAYHLSCLGL GKRPFGKWEC PWHHCDVCGK PSTSFCHFCP NSFCKEHQDG TAFSSTQDGR 1320 SYCCEHDLGA ESVRSAKTEK PFPEPMKSKG KRKKRRCWRR VTEGK 1365 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NSD2 | 102186471 | A0A452E027 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NSD2 | A0A5F5PRN6 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | NSD2 | 7468 | O96028 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nsd2 | 107823 | Q8BVE8 | CPO | E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | NSD2 | 461070 | H2QP41 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NSD2 | F1S8S1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nsd2 | 680537 | D4A9J4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005634 | nucleus |
| GO:0003677 | DNA binding |
| GO:0018024 | histone-lysine N-methyltransferase activity |
| GO:0046872 | metal ion binding |
| InterPro ID | InterPro Term |
|---|---|
| IPR006560 | AWS_dom |
| IPR041306 | C5HCH |
| IPR009071 | HMG_box_dom |
| IPR036910 | HMG_box_dom_sf |
| IPR003616 | Post-SET_dom |
| IPR000313 | PWWP_dom |
| IPR001214 | SET_dom |
| IPR019786 | Zinc_finger_PHD-type_CS |
| IPR011011 | Znf_FYVE_PHD |
| IPR001965 | Znf_PHD |
| IPR019787 | Znf_PHD-finger |
| IPR001841 | Znf_RING |
| IPR013083 | Znf_RING/FYVE/PHD |