| Tag | Content |
|---|---|
| Uniprot ID | D4A9J4 |
| Entrez ID | 680537 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001191552.1 |
| Ensembl protein ID | ENSRNOP00000021952 |
| Ensembl nucleotide ID | ENSRNOG00000038140 |
| Gene name | Nuclear receptor-binding SET domain protein 2 |
| Gene symbol | Nsd2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MKQAPEILGS ANGKTQNCEV NHECSVFLSK AQLSNSLQEG VMQKFNGHDA LPFLPAEKLK 60 DLTSCVFNGE PGAHDTKLCF ETQEVKGIGT PPNTTPIKNG SPEIKLKITK TYMNGKPLFE 120 SSICGDGAAD MSQSEENGQK SDNKTRRNRK RSIKYDSLLE QGLVEAALVS KISSPEDKKI 180 PVKKESCPNS GRDRDLLLKY NVGDLVWSKV SGYPWWPCMV SADPLLHNHT KLKGQKKSAR 240 QYHVQFFGDA PERAWIFEKS LVAFEGEEQF EKLCQESAKQ APTKAEKIKL LKPISGRLRA 300 QWEMGIVQAE EAASMSVEER KAKFTFLYVG DQLRLNPQVA KEAGIATEPL GEMVDSSVAN 360 EEAAVDPGTM REEDIPVKRR RRAKRSSSAE NQEGDPGTEK STPPKMADAE PKRGVGSPAG 420 RKRSTGSASR SRKGDSAAQF LVFCQKHRDE VVAEHPDASE EEIEELLGSQ WSMLNEKQKA 480 RYNTKFSLMI SAQSEEDSGN TSGKKRTHTK RTDDPPEDVD VEDAPRKRLR TDKHSLRKQR 540 ETITDKTART SSYKAIEAAS SLKSQAATKN LSDACKPLKK RNRASATASS ALGFNKSSSP 600 SASLTENEVS DNPGDEPSES PYESADETQT EASVSSKKSE RGMAAKKEYV CQLCEKTGSL 660 LLCEGPCCGA FHLACLGLSQ RPEGRFTCTE CASGIHSCFV CKESKMEVKR CMVNQCGKFY 720 HEACVKKYPL TVFESRGFRC PLHSCMSCHA SNPSNPRPSK GKMMRCVRCP VAYHGGDACL 780 AAGCSVIASN SIICTGHFTA RKGKRHHTHV NVSWCFVCSK GGSLLCCEAC PAAFHPDCLS 840 IEMPDGSWFC NDCRAGKKLH FQDIIWVKLG NYRWWPAEVC HPKNVPPNIQ KMKHEIGEFP 900 VFFFGSKDYY WTHQARVFPY MEGDRGSRYQ GVRGIGRVFK NALQEAEARF NEIKLQREAR 960 ETQESERKPP PYKHIKVNKP YGKVQIYTAD ISEIPKCNCK PTDENPCGSD SECLNRMLMF 1020 ECHPQVCPAG EYCQNQCFTK RQYPETKIIK TDGKGWGLVA KRDIRKGEFV NEYVGELIDE 1080 EECMARIKYA HENDITHFYM LTIDKDRIID AGPKGNYSRF MNHSCQPNCE TLKWTVNGDT 1140 RVGLFAVCDI PAGTELTFNY NLDCLGNEKT VCRCGASNCS GFLGDRPKTS TSLSSEEKSK 1200 KAKKKTRRRR AKGEGKRQSE DECFRCGDGG QLVLCDRKFC TKAYHLSCLG LGKRPFGKWE 1260 CPWHHCDVCG KPSTSFCHLC PNSFCKEHQD GTAFRSTQDG QSYCCEHDLR ADSANNTKTE 1320 KPFLDSLKAK GKRKKRRCWR RVTDGK 1346 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NSD2 | 102186471 | A0A452E027 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NSD2 | A0A5F5PRN6 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | NSD2 | 7468 | O96028 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nsd2 | 107823 | Q8BVE8 | CPO | E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | NSD2 | 461070 | H2QP41 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NSD2 | F1S8S1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nsd2 | 680537 | D4A9J4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000785 | chromatin |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0046975 | histone methyltransferase activity (H3-K36 specific) |
| GO:0018024 | histone-lysine N-methyltransferase activity |
| GO:0046872 | metal ion binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0003289 | atrial septum primum morphogenesis |
| GO:0003290 | atrial septum secundum morphogenesis |
| GO:0060348 | bone development |
| GO:0010452 | histone H3-K36 methylation |
| GO:0034770 | histone H4-K20 methylation |
| GO:0003149 | membranous septum morphogenesis |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0048298 | positive regulation of isotype switching to IgA isotypes |
| GO:2001032 | regulation of double-strand break repair via nonhomologous end joining |
| GO:0070201 | regulation of establishment of protein localization |
| GO:0006355 | regulation of transcription, DNA-templated |
| InterPro ID | InterPro Term |
|---|---|
| IPR006560 | AWS_dom |
| IPR041306 | C5HCH |
| IPR009071 | HMG_box_dom |
| IPR036910 | HMG_box_dom_sf |
| IPR003616 | Post-SET_dom |
| IPR000313 | PWWP_dom |
| IPR001214 | SET_dom |
| IPR019786 | Zinc_finger_PHD-type_CS |
| IPR011011 | Znf_FYVE_PHD |
| IPR001965 | Znf_PHD |
| IPR019787 | Znf_PHD-finger |
| IPR001841 | Znf_RING |
| IPR013083 | Znf_RING/FYVE/PHD |