| Tag | Content |
|---|---|
| Uniprot ID | H2QP41; A0A2J8K6L6; |
| Entrez ID | 461070 |
| Genbank protein ID | JAA36301.1; JAA17713.1; JAA28255.1; JAA11109.1; |
| Genbank nucleotide ID | XM_009447235.2; XM_016951141.1; XM_009447234.2; XM_016951143.1; XM_016951142.1; |
| Ensembl protein ID | ENSPTRP00000027281 |
| Ensembl nucleotide ID | ENSPTRG00000015838 |
| Gene name | Nuclear receptor binding SET domain protein 2 |
| Gene symbol | NSD2 |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MEFSIKQSPL SVQSVVKCIK MKQAPEILGS ANGKTPSCEV NRECSVFLSK AQLSSSLQEG 60 VMQKFNGHDA LPFIPADKLK DLTSRVFNGE PGAHDAKLRF ESQEMKGIGT PPNTTPIKNG 120 SPEIKLKITK TYMNGKPLFE SSICGDSAAD VSQSEENGQK PENKARRNRK RSIKYDSLLE 180 QGLVEAALVS KISSPSDKKI PAKKESCPNT GRDKDHLLKY NVGDLVWSKV SGYPWWPCMV 240 SADPLLHSYT KLKGQKKSAR QYHVQFFGDA PERAWIFEKS LVAFEGEGQF EKLCQESAKQ 300 APTKAEKIKL LKPISGKLRA QWEMGIVQAE EAASMSVEER KAKFTFLYVG DQLHLNPQVA 360 KEAGIAAESL GEMAESSGVG EEAAENPKSV REECIPMKRR RRAKLCSSAE TLESHPDIGK 420 STPQKTAEAD PRRGVGSPPG RKKTTVSMPR SRKGDAASQF LVFCQKHRDE VVAEHPDASG 480 EEIEELLRSQ WSLLSEKQRA RYNTKFALVA PVQAEEDSGN VNGKKRNHTK RIQDPTEDAE 540 AEDTPRKRLR TDKHSLRKRD TITDKTARTS SYKAMEAASS LKSQAATKNL SDACKPLKKR 600 NRASTAASSA LGFSKSSSPS ASLTENEVSD SPGDEPSESP YESADETQTE VSVSSKKSER 660 GVTAKKEYVC QLCEKPGSLL LCEGPCCGAF HLACLGLSRR PEGRFTCSEC ASGIHSCFVC 720 KESKTDVKRC VVTQCGKFYH EACVKKYPLT VFESRGFRCP LHSCVSCHAS NPSNPRPSKG 780 KMMRCVRCPV AYHSGDACLA AGCSVIASNS IICTAHFTAR KGKRHHAHVN VSWCFVCSKG 840 GSLLCCESCP AAFHPDCLNI EMPDGSWFCN DCRAGKKLHF QDIIWVKLGN YRWWPAEVCH 900 PKNVPPNIQK MKHEIGEFPV FFFGSKDYYW THQARVFPYM EGDRGSRYQG VRGIGRVFKN 960 ALQEAEARFR EIKLQREARE TQESERKPPP YKHIKVNKPY GKVQIYTADI SEIPKCNCKP 1020 TDENPCGFDS ECLNRMLMFE CHPQVCPAGE FCQNQCFTKR QYPETKIIKT DGKGWGLVAK 1080 RDIRKGEFVN EYVGELIDEE ECMARIKHAH ENDITHFYML TIDKDRIIDA GPKGNYSRFM 1140 NHSCQPNCET LKWTVNGDTR VGLFAVCDIP AGTELTFNYN LDCLGNEKTV CRCGASNCSG 1200 FLGDRPKTST TLSSEEKGKK TKKKMRRRRA KGEGKRQSED ECFRCGDGGQ LVLCDRKFCT 1260 KAYHLSCLGL GKRPFGKWEC PWHHCDVCGK PSTSFCHLCP NSFCKEHQDG TAFSCTPDGR 1320 SYCCEHDLGA ASVRSTKTEK PPPEPGKPKG KRRRRRGWRR VTEGK 1365 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NSD2 | 102186471 | A0A452E027 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | NSD2 | A0A5F5PRN6 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | NSD2 | 7468 | O96028 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nsd2 | 107823 | Q8BVE8 | CPO | E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | NSD2 | 461070 | H2QP41 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NSD2 | F1S8S1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Nsd2 | 680537 | D4A9J4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0000785 | chromatin |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0003682 | chromatin binding |
| GO:0046975 | histone methyltransferase activity (H3-K36 specific) |
| GO:0046872 | metal ion binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0003289 | atrial septum primum morphogenesis |
| GO:0003290 | atrial septum secundum morphogenesis |
| GO:0060348 | bone development |
| GO:0034770 | histone H4-K20 methylation |
| GO:0003149 | membranous septum morphogenesis |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0048298 | positive regulation of isotype switching to IgA isotypes |
| GO:2001032 | regulation of double-strand break repair via nonhomologous end joining |
| GO:0070201 | regulation of establishment of protein localization |
| GO:0006355 | regulation of transcription, DNA-templated |
| InterPro ID | InterPro Term |
|---|---|
| IPR006560 | AWS_dom |
| IPR041306 | C5HCH |
| IPR009071 | HMG_box_dom |
| IPR036910 | HMG_box_dom_sf |
| IPR003616 | Post-SET_dom |
| IPR000313 | PWWP_dom |
| IPR001214 | SET_dom |
| IPR019786 | Zinc_finger_PHD-type_CS |
| IPR011011 | Znf_FYVE_PHD |
| IPR001965 | Znf_PHD |
| IPR019787 | Znf_PHD-finger |
| IPR001841 | Znf_RING |
| IPR013083 | Znf_RING/FYVE/PHD |