| Tag | Content |
|---|---|
| Uniprot ID | A1C2V0 |
| Entrez ID | 470605 |
| Genbank protein ID | ABI48526.1; ABI48524.1; ABI48522.1; ABI48525.1; ABI48523.1; |
| Genbank nucleotide ID | NM_001079919.1 |
| Ensembl protein ID | |
| Ensembl nucleotide ID | |
| Gene name | Growth/differentiation factor 8 |
| Gene symbol | MSTN |
| Organism | Pan troglodytes |
| NCBI taxa ID | 9598 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts specifically as a negative regulator of skeletal muscle growth. |
| Sequence | MQKLQLCVYI YLFMLIVAGP VDLNENSEQK ENVEKEGLCN ACTWRQNTKS SRIEAIKIQI 60 LSKLRLETAP NISKDAIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHATTETIIT 120 MPTESDFLMQ VDGKPKCCFF KFSSKIQYNK VVKAQLWIYL RPVETPTTVF VQILRLIKPM 180 KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT 240 FPGPGEDGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA 300 PKRYKANYCS GECEFVFLQK YPHTHLVHQA NPRGSAGPCC TPTKMSPINM LYFNGKEQII 360 YGKIPAMVVD RCGCS 375 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSTN | 281187 | O18836 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 403433 | Q6UKZ8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 100860887 | Q6T5B8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | F6S5D9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | MSTN | 2660 | O14793 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 17700 | O08689 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MSTN | 470605 | A1C2V0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSTN | O18831 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | mstn | 100125998 | A7LH84 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 29152 | O35312 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mstnb | 798441 | O42222 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0042802 | identical protein binding |
| GO:0014839 | myoblast migration involved in skeletal muscle regeneration |
| GO:2000818 | negative regulation of myoblast proliferation |
| GO:1902725 | negative regulation of satellite cell differentiation |
| GO:1902723 | negative regulation of skeletal muscle satellite cell proliferation |
| GO:0010592 | positive regulation of lamellipodium assembly |
| GO:0010759 | positive regulation of macrophage chemotaxis |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0060395 | SMAD protein signal transduction |