| Tag | Content |
|---|---|
| Uniprot ID | O42222; B0S643; Q7T1K5; Q8JFS0; Q8UUR8; |
| Entrez ID | 798441 |
| Genbank protein ID | AAB86693.1; CAC86466.1; AAP85526.1; CAQ13470.1; AAP13068.1; CAD43439.1; AAQ11222.1; |
| Genbank nucleotide ID | NM_131019.5 |
| Ensembl protein ID | ENSDARP00000091159 |
| Ensembl nucleotide ID | ENSDARG00000069133 |
| Gene name | Growth/differentiation factor 8 |
| Gene symbol | mstnb |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts specifically as a negative regulator of skeletal muscle growth. May down-regulate muscle-specific transcription factors such as myod and myog. |
| Sequence | MHFTQVLISL SVLIACGPVG YGDITAHQQP STATEESEQC STCEFRQHSK LMRLHAIKSQ 60 ILSKLRLKQA PNISRDVVKQ LLPKAPPLQQ LLDQYDVLGD DSKDGAVEED DEHATTETIM 120 TMATEPDPIV QVDRKPKCCF FSFSPKIQAN RIVRAQLWVH LRPAEEATTV FLQISRLMPV 180 KDGGRHRIRS LKIDVNAGVT SWQSIDVKQV LTVWLKQPET NRGIEINAYD AKGNDLAVTS 240 TETGEDGLLP FMEVKISEGP KRIRRDSGLD CDENSSESRC CRYPLTVDFE DFGWDWIIAP 300 KRYKANYCSG ECDYMYLQKY PHTHLVNKAS PRGTAGPCCT PTKMSPINML YFNGKEQIIY 360 GKIPSMVVDR CGCS 374 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSTN | 281187 | O18836 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 403433 | Q6UKZ8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 100860887 | Q6T5B8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | F6S5D9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | MSTN | 2660 | O14793 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 17700 | O08689 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MSTN | 470605 | A1C2V0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSTN | O18831 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | mstn | 100125998 | A7LH84 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 29152 | O35312 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mstnb | 798441 | O42222 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005576 | extracellular region |
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0110021 | cardiac muscle myoblast proliferation |
| GO:0006955 | immune response |
| GO:0007517 | muscle organ development |
| GO:0110023 | negative regulation of cardiac muscle myoblast proliferation |
| GO:0045926 | negative regulation of growth |
| GO:0045967 | negative regulation of growth rate |
| GO:0048642 | negative regulation of skeletal muscle tissue development |
| GO:0045843 | negative regulation of striated muscle tissue development |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0014738 | regulation of muscle hyperplasia |
| GO:0007519 | skeletal muscle tissue development |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |
| GO:0003222 | ventricular trabecula myocardium morphogenesis |