| Tag | Content |
|---|---|
| Uniprot ID | O08689 |
| Entrez ID | 17700 |
| Genbank protein ID | AAC53167.1 |
| Genbank nucleotide ID | NM_010834.3 |
| Ensembl protein ID | ENSMUSP00000027269 |
| Ensembl nucleotide ID | ENSMUSG00000026100 |
| Gene name | Growth/differentiation factor 8 |
| Gene symbol | Mstn |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 19298661 |
| Functional description | Acts specifically as a negative regulator of skeletal muscle growth. |
| Sequence | MMQKLQMYVY IYLFMLIAAG PVDLNEGSER EENVEKEGLC NACAWRQNTR YSRIEAIKIQ 60 ILSKLRLETA PNISKDAIRQ LLPRAPPLRE LIDQYDVQRD DSSDGSLEDD DYHATTETII 120 TMPTESDFLM QADGKPKCCF FKFSSKIQYN KVVKAQLWIY LRPVKTPTTV FVQILRLIKP 180 MKDGTRYTGI RSLKLDMSPG TGIWQSIDVK TVLQNWLKQP ESNLGIEIKA LDENGHDLAV 240 TFPGPGEDGL NPFLEVKVTD TPKRSRRDFG LDCDEHSTES RCCRYPLTVD FEAFGWDWII 300 APKRYKANYC SGECEFVFLQ KYPHTHLVHQ ANPRGSAGPC CTPTKMSPIN MLYFNGKEQI 360 IYGKIPAMVV DRCGCS 376 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSTN | 281187 | O18836 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 403433 | Q6UKZ8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 100860887 | Q6T5B8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | F6S5D9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | MSTN | 2660 | O14793 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 17700 | O08689 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MSTN | 470605 | A1C2V0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSTN | O18831 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | mstn | 100125998 | A7LH84 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 29152 | O35312 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mstnb | 798441 | O42222 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005102 | signaling receptor binding | ISO |
| GO:0005102 | signaling receptor binding | IPI |
| GO:0005125 | cytokine activity | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0008083 | growth factor activity | IEA |
| GO:0008201 | heparin binding | IDA |
| GO:0042802 | identical protein binding | ISO |
| GO:0042802 | identical protein binding | IDA |
| GO:0042803 | protein homodimerization activity | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0007179 | transforming growth factor beta receptor signaling pathway | IDA |
| GO:0009408 | response to heat | IEA |
| GO:0009629 | response to gravity | IEA |
| GO:0010592 | positive regulation of lamellipodium assembly | IMP |
| GO:0010759 | positive regulation of macrophage chemotaxis | IMP |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | IBA |
| GO:0014732 | skeletal muscle atrophy | IEA |
| GO:0014741 | negative regulation of muscle hypertrophy | ISO |
| GO:0014839 | myoblast migration involved in skeletal muscle regeneration | IMP |
| GO:0014850 | response to muscle activity | IEA |
| GO:0022602 | ovulation cycle process | IEA |
| GO:0033574 | response to testosterone | IEA |
| GO:0033673 | negative regulation of kinase activity | IMP |
| GO:0043627 | response to estrogen | IEA |
| GO:0045471 | response to ethanol | IEA |
| GO:0045662 | negative regulation of myoblast differentiation | ISO |
| GO:0045893 | positive regulation of transcription, DNA-templated | ISO |
| GO:0046627 | negative regulation of insulin receptor signaling pathway | IMP |
| GO:0046716 | muscle cell cellular homeostasis | ISO |
| GO:0048632 | negative regulation of skeletal muscle tissue growth | ISO |
| GO:0048632 | negative regulation of skeletal muscle tissue growth | IMP |
| GO:0051602 | response to electrical stimulus | IEA |
| GO:0051898 | negative regulation of protein kinase B signaling | ISO |
| GO:0060395 | SMAD protein signal transduction | IBA |
| GO:0071549 | cellular response to dexamethasone stimulus | IDA |
| GO:1902723 | negative regulation of skeletal muscle satellite cell proliferation | ISS |
| GO:1902725 | negative regulation of satellite cell differentiation | ISS |
| GO:2000818 | negative regulation of myoblast proliferation | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | TAS |
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IDA |
| GO:0005615 | extracellular space | IBA |
| GO:0005623 | cell | IEA |
| GO:0005737 | cytoplasm | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|