| Tag | Content |
|---|---|
| Uniprot ID | O35312 |
| Entrez ID | 29152 |
| Genbank protein ID | AAB86691.1 |
| Genbank nucleotide ID | NM_019151.1 |
| Ensembl protein ID | ENSRNOP00000038159 |
| Ensembl nucleotide ID | ENSRNOG00000021294 |
| Gene name | Growth/differentiation factor 8 |
| Gene symbol | Mstn |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts specifically as a negative regulator of skeletal muscle growth. |
| Sequence | MIQKPQMYVY IYLFVLIAAG PVDLNEDSER EANVEKEGLC NACAWRQNTR YSRIEAIKIQ 60 ILSKLRLETA PNISKDAIRQ LLPRAPPLRE LIDQYDVQRD DSSDGSLEDD DYHATTETII 120 TMPTESDFLM QADGKPKCCF FKFSSKIQYN KVVKAQLWIY LRAVKTPTTV FVQILRLIKP 180 MKDGTRYTGI RSLKLDMSPG TGIWQSIDVK TVLQNWLKQP ESNLGIEIKA LDENGHDLAV 240 TFPGPGEDGL NPFLEVKVTD TPKRSRRDFG LDCDEHSTES RCCRYPLTVD FEAFGWDWII 300 APKRYKANYC SGECEFVFLQ KYPHTHLVHQ ANPRGSAGPC CTPTKMSPIN MLYFNGKEQI 360 IYGKIPAMVV DRCGCS 376 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSTN | 281187 | O18836 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 403433 | Q6UKZ8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 100860887 | Q6T5B8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | F6S5D9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | MSTN | 2660 | O14793 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 17700 | O08689 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MSTN | 470605 | A1C2V0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSTN | O18831 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | mstn | 100125998 | A7LH84 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 29152 | O35312 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mstnb | 798441 | O42222 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005737 | cytoplasm |
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0042802 | identical protein binding |
| GO:0042803 | protein homodimerization activity |
| GO:0005102 | signaling receptor binding |
| GO:0071549 | cellular response to dexamethasone stimulus |
| GO:0046716 | muscle cell cellular homeostasis |
| GO:0014839 | myoblast migration involved in skeletal muscle regeneration |
| GO:0046627 | negative regulation of insulin receptor signaling pathway |
| GO:0033673 | negative regulation of kinase activity |
| GO:0014741 | negative regulation of muscle hypertrophy |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:2000818 | negative regulation of myoblast proliferation |
| GO:0051898 | negative regulation of protein kinase B signaling |
| GO:1902725 | negative regulation of satellite cell differentiation |
| GO:1902723 | negative regulation of skeletal muscle satellite cell proliferation |
| GO:0048632 | negative regulation of skeletal muscle tissue growth |
| GO:0022602 | ovulation cycle process |
| GO:0010592 | positive regulation of lamellipodium assembly |
| GO:0010759 | positive regulation of macrophage chemotaxis |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0051602 | response to electrical stimulus |
| GO:0043627 | response to estrogen |
| GO:0045471 | response to ethanol |
| GO:0051384 | response to glucocorticoid |
| GO:0009629 | response to gravity |
| GO:0009408 | response to heat |
| GO:0014850 | response to muscle activity |
| GO:0033574 | response to testosterone |
| GO:0014732 | skeletal muscle atrophy |
| GO:0043403 | skeletal muscle tissue regeneration |
| GO:0060395 | SMAD protein signal transduction |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |