| Tag | Content |
|---|---|
| Uniprot ID | Q6T5B8; Q3S4A8; |
| Entrez ID | 100860887 |
| Genbank protein ID | AAZ95183.2; AAR12161.1; |
| Genbank nucleotide ID | NM_001285737.1 |
| Ensembl protein ID | ENSCHIP00000026815 |
| Ensembl nucleotide ID | ENSCHIG00000022964 |
| Gene name | Growth/differentiation factor 8 |
| Gene symbol | MSTN |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Acts specifically as a negative regulator of skeletal muscle growth. |
| Sequence | MQKLQIFVYI YLFMLLVAGP VDLNENSEQK ENVEKKGLCN ACLWRQNNKS SRLEAIKIQI 60 LSKLRLETAP NISKDAIRQL LPKAPPLREL IDQYDVQRDD SSDGSLEDDD YHVTTETVIT 120 MPTESDLLAE VQEKPKCCFF KFSSKIQHNK VVKAQLWIYL RPVKTPTTVF VQILRLIKPM 180 KDGTRYTGIR SLKLDMNPGT GIWQSIDVKT VLQNWLKQPE SNLGIEIKAL DENGHDLAVT 240 FPEPGEEGLN PFLEVKVTDT PKRSRRDFGL DCDEHSTESR CCRYPLTVDF EAFGWDWIIA 300 PKRYKANYCS GECEFLFLQK YPHTHLVHQA NPKGSAGPCC TPTKMSPINM LYFNGKEQII 360 YGKIPGMVVD RCGCS 375 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | MSTN | 281187 | O18836 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 403433 | Q6UKZ8 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | MSTN | 100860887 | Q6T5B8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | MSTN | F6S5D9 | Equus caballus | Prediction | More>> | |||
| 1:1 ortholog | MSTN | 2660 | O14793 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 17700 | O08689 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | MSTN | 470605 | A1C2V0 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | MSTN | O18831 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | mstn | 100125998 | A7LH84 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Mstn | 29152 | O35312 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | mstnb | 798441 | O42222 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0008201 | heparin binding |
| GO:0042802 | identical protein binding |
| GO:0042803 | protein homodimerization activity |
| GO:0071549 | cellular response to dexamethasone stimulus |
| GO:0046716 | muscle cell cellular homeostasis |
| GO:0014839 | myoblast migration involved in skeletal muscle regeneration |
| GO:0046627 | negative regulation of insulin receptor signaling pathway |
| GO:0033673 | negative regulation of kinase activity |
| GO:0045662 | negative regulation of myoblast differentiation |
| GO:0051898 | negative regulation of protein kinase B signaling |
| GO:0048632 | negative regulation of skeletal muscle tissue growth |
| GO:0010592 | positive regulation of lamellipodium assembly |
| GO:0010759 | positive regulation of macrophage chemotaxis |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0007179 | transforming growth factor beta receptor signaling pathway |