| Tag | Content |
|---|---|
| Uniprot ID | A2A690; A2A683; Q3TRZ3; Q5EBP6; Q69ZQ7; |
| Entrez ID | 77097 |
| Genbank protein ID | BAE36883.1; AAH89352.1; BAD32389.1; |
| Genbank nucleotide ID | NM_181071.3 |
| Ensembl protein ID | ENSMUSP00000097904 |
| Ensembl nucleotide ID | ENSMUSG00000053580 |
| Gene name | Protein TANC2 |
| Gene symbol | Tanc2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Scaffolding protein in the dendritic spines which acts as immobile postsynaptic posts able to recruit KIF1A-driven dense core vesicles to dendritic spines. |
| Sequence | MFRNSLKMLL TGGKSSRKNR SSDGGSEEPP DRRQSSVDSR QSRSGQGGIS TESDCAFEPD 60 YAVPPLPVSE GDVEQELGPP PSVDEAANTL MTRLGFLLGE KVTEVQPSDQ YSMEVQDENQ 120 TSAITQRISP CSTLTSSTAS PPASSPCSTL PPVSTNAAAK DCSYGAVTSP TSTLESRDSG 180 IIATLTNYSE NMERTKYVGE GSKELGSGGN LKPWQSQKSS MDSCLYRVDE NMAASTYSLN 240 KIPERNLETV LSQSVQSIPL YLMPRPNSVA ATSSAHLEDL AYLDEQRHTP LRTSLRMPRQ 300 SLSGARTQQD LRVRFAPYRP PDISLKPLLF EVPSITTESV FVGRDWVFHE IDAQLQSSNA 360 SVNQGVVIVG NIGFGKTAII SRLVALSCHG TRMRQIASDS PHASPKHVDA NRELPLTQAP 420 SAHSSITSGS CPGTPEMRRR QEEAMRRLAS QVVAYHYCQA DNAYTCLVPE FVHNVAALLC 480 RSPQLTAYRE QLLREPHLQS MLSLRSCVQD PMASFRRGVL EPLENLHKER KIPDEDFIIL 540 IDGLNEAEFH KPDYGDTIVS FLSKMIGNFP SWLKLIVTVR TSLQEITKLL PFHRIFLDRL 600 EENEAIDQDL QAYILHRIHS SSEIQNNISL NGKMDNTTFG KLSSHLKTLS QGSYLYLKLT 660 FDLIEKGYLV LKSSSYKVVP VSLSEVYLLQ CNMKFPTQSS FDRVMPLLNV AVASLHPLTD 720 EHIFQAINAG SIEGTLEWED FQQRMENLSM FLIKRRDMTR MFVHPSFREW LIWREEGEKT 780 KFLCDPRSGH TLLAFWFSRQ EGKLNRQQTI ELGHHILKAH IFKGLSKKVG VSSSILQGLW 840 ISYSTEGLSM ALASLRNLYT PNIKVSRLLI LGGANINYRT EVLNNAPILC VQSHLGYTEM 900 VALLLEFGAN VDASSESGLT PLGYAAAAGF LSIVVLLCKK RAKVDHLDKN GQCALVHAAL 960 RGHLEVVKFL IQCDWTMAGQ QQGVFKKSHA IQQALIAAAS MGYTEIVSYL LDLPEKDEEE 1020 VERAQINSFD SLWGETALTA AAGRGKLDVC RLLLEQGAAV AQPNRRGAVP LFSTVRQGHW 1080 QIVDLLLTHG ADVNMADKQG RTPLMMAASE GHLGTVDFLL AQGASIALMD KEGLTALSWA 1140 CLKGHLSVVR SLVDNGAATD HADKNGRTPL DLAAFYGDAE VVQFLVDHGA MIEHVDYSGM 1200 RPLDRAVGCR NTSVVVTLLK KGAKIGPATW AMATSKPDIM IILLSKLMEE GDMFYKKGKV 1260 KEAAQRYQYA LKKFPREGFG EDLKTFRELK VSLLLNLSRC RRKMNDFGMA EEFATKALEL 1320 KPKSYEAYYA RARAKRSSRQ FAAALEDLKE AIKLCPNNRE IQRLLMRVEE ECRQMQQQQQ 1380 QQPPPPPQQP PQELPEEETE PEPQHEDIYS VQDIFEEEYL EQDVENVSIG LQTEARPSQG 1440 LPVIQSPPSS PAHRDSAYIS SSPLGSHQVF DFRSNSSVGS PTRQGYQSTS PALSPTHQNS 1500 HYRPSPPHTS PAHQGASYRF SPPPVGGQSK EYPSPPPSPL RRGPQYRASP PAESMSVYRS 1560 QSGSPVRYQQ ETNVSQLPGR PKSPLSKMAQ RPYQMPQLPV AVPQQGLRLQ PAKAQIVRSN 1620 QPSSAVHSST VIPTGAYGQV AHSMASKYQS SQGDMGVSQS RLVYQGSIGG IVGDGRPVQH 1680 VQASLSAGAI CQHGGLTKED LPQRPSSAYR GGMRYSQTPQ IGRSQSASYY PVCHSKLDLE 1740 RSSSQLGSPD VSHLIRRPIS VNPNEIKPHP PTPRPLLHSQ SVGLRFSPSS NSISSTSNLT 1800 PTFRPSSSIQ QMEIPLKPAY DRSCDELSPV SPTQGGYPSE PTRSRTTPFM GIIDKTARTQ 1860 QYPHLHQQNR TWAVSSVDTV LSPTSPGNLP QPESFSPPSS ISNIAFYNKT NNAQNGHLLE 1920 DDYYSPHGML ANGSRGDLLE RVSQASSYPD VKVARTLPVA QAYQDNLYRQ LSRDSRQGQT 1980 SPIKPKRPFV ESNV 1994 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | TANC2 | F1PAF9 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | TANC2 | A0A452DN91 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | TANC2 | 26115 | Q9HCD6 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Tanc2 | 77097 | A2A690 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | TANC2 | 454784 | H2QDM5 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | TANC2 | F1RRV1 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Tanc2 | 303599 | A0A0G2K9J0 | Rattus norvegicus | Prediction | More>> |
| Gene symbol | Significant Variants/SNPS | Methods | PubMed ID |
|---|---|---|---|
| TANC2 | rs1588366 | Genotyping and GWAS | 27033726 |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003674 | molecular_function | ND |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001701 | in utero embryonic development | IMP |
| GO:0060998 | regulation of dendritic spine development | ISS |
| GO:0060998 | regulation of dendritic spine development | ISO |
| GO:0061001 | regulation of dendritic spine morphogenesis | ISS |
| GO:0061001 | regulation of dendritic spine morphogenesis | ISO |
| GO:0099519 | dense core granule cytoskeletal transport | ISS |
| GO:0099519 | dense core granule cytoskeletal transport | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0030054 | cell junction | IEA |
| GO:0030424 | axon | IEA |
| GO:0043197 | dendritic spine | ISS |
| GO:0043197 | dendritic spine | ISO |
| GO:0098978 | glutamatergic synapse | ISO |
| GO:0099092 | postsynaptic density, intracellular component | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|