| Tag | Content |
|---|---|
| Uniprot ID | A2ARI4; A2ARI3; Q6PHA3; Q80T31; Q8BXS9; |
| Entrez ID | 107515 |
| Genbank protein ID | AAO85131.1; AAH56637.1; BAC31882.1; |
| Genbank nucleotide ID | NM_172671.2 |
| Ensembl protein ID | ENSMUSP00000106666; ENSMUSP00000047325; |
| Ensembl nucleotide ID | ENSMUSG00000050199 |
| Gene name | Leucine-rich repeat-containing G-protein coupled receptor 4 |
| Gene symbol | Lgr4 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 29769720 |
| Functional description | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (PubMed:24353284). |
| Sequence | MPGPLRLLCF FALGLLGSAG PSGAAPPLCA APCSCDGDRR VDCSGKGLTA VPEGLSAFTQ 60 ALDISMNNIT QLPEDAFKNF PFLEELQLAG NDLSFIHPKA LSGLKELKVL TLQNNQLKTV 120 PSEAIRGLSA LQSLRLDANH ITSVPEDSFE GLVQLRHLWL DDNILTEVPV RPLSNLPTLQ 180 ALTLALNNIS SIPDFAFTNL SSLVVLHLHN NKIKSLSQHC FDGLDNLETL DLNYNNLDEF 240 PQAIKALPSL KELGFHSNSI SVIPDGAFAG NPLLRTIHLY DNPLSFVGNS AFHNLSDLHS 300 LVIRGASLVQ WFPNLAGTVH LESLTLTGTK ISSIPDDLCQ NQKMLRTLDL SYNDIRDLPS 360 FNGCRALEEI SLQRNQISLI KETTFQGLTS LRILDLSRNL IREIHSGAFA KLGTITNLDV 420 SFNELTSFPT EGLNGLNQLK LVGNFQLKDA LAARDFANLR SLSVPYAYQC CAFWGCDSYA 480 NLNTEDNSPQ DHSVTKEKGA TDAANATSTA ESEEHSQIII HCTPSTGAFK PCEYLLGSWM 540 IRLTVWFIFL VALLFNLLVI LTVFASCSSL PASKLFIGLI SVSNLLMGIY TGILTFLDAV 600 SWGRFAEFGI WWETGSGCKV AGSLAVFSSE SAVFLLTLAA VERSVFAKDV MKNGKSSHLR 660 QFQVAALVAL LGAAIAGCFP LFHGGQYSAS PLCLPFPTGE TPSLGFTVTL VLLNSLAFLL 720 MAIIYTKLYC NLEKEDPSEN SQSSMIKHVA WLIFTNCIFF CPVAFFSFAP LITAISISPE 780 IMKSVTLIFF PLPACLNPVL YVFFNPKFKD DWKLLKRRVT RKHGSVSVSI SSQGGCGEQD 840 FYYDCGMYSH LQGNLTVCDC CESFLLTKPV SCKHLIKSHS CPVLTVASCQ RPEAYWSDCG 900 TQSAHSDYAD EEDSFVSDSS DQVQACGRAC FYQSRGFPLV RYAYNLPRVR D 951 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LGR4 | A0A452GBK2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | LGR4 | 55366 | Q9BXB1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Lgr4 | 107515 | A2ARI4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | LGR4 | H2R5I5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | LGR4 | 100518646 | F1SGM5 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | LGR4 | 100356429 | G1SL01 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Lgr4 | 286994 | Q9Z2H4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lgr4 | 558825 | E7FE13 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004888 | transmembrane signaling receptor activity | ISO |
| GO:0004888 | transmembrane signaling receptor activity | IDA |
| GO:0005515 | protein binding | IPI |
| GO:0008201 | heparin binding | IBA |
| GO:0016500 | protein-hormone receptor activity | IEA |
| GO:0048495 | Roundabout binding | IBA |
| GO:0004930 | G protein-coupled receptor activity | IDA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001649 | osteoblast differentiation | IMP |
| GO:0001942 | hair follicle development | IGI |
| GO:0001942 | hair follicle development | IMP |
| GO:0007186 | G protein-coupled receptor signaling pathway | IEA |
| GO:0007283 | spermatogenesis | IMP |
| GO:0007411 | axon guidance | IBA |
| GO:0007623 | circadian rhythm | IEP |
| GO:0030282 | bone mineralization | IMP |
| GO:0030539 | male genitalia development | IMP |
| GO:0032922 | circadian regulation of gene expression | IMP |
| GO:0034122 | negative regulation of toll-like receptor signaling pathway | IMP |
| GO:0035239 | tube morphogenesis | IMP |
| GO:0036335 | intestinal stem cell homeostasis | IMP |
| GO:0045087 | innate immune response | IEA |
| GO:0045892 | negative regulation of transcription, DNA-templated | IMP |
| GO:0045893 | positive regulation of transcription, DNA-templated | IMP |
| GO:0046849 | bone remodeling | IMP |
| GO:0048565 | digestive tract development | IMP |
| GO:0050673 | epithelial cell proliferation | IMP |
| GO:0050710 | negative regulation of cytokine secretion | IMP |
| GO:0050919 | negative chemotaxis | IBA |
| GO:0061290 | canonical Wnt signaling pathway involved in metanephric kidney development | IMP |
| GO:0072202 | cell differentiation involved in metanephros development | IMP |
| GO:0072224 | metanephric glomerulus development | IMP |
| GO:0072282 | metanephric nephron tubule morphogenesis | IMP |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis | IMP |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | ISO |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IDA |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway | IMP |
| GO:0120163 | negative regulation of cold-induced thermogenesis | IMP |
| GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005887 | integral component of plasma membrane | ISO |
| GO:0005887 | integral component of plasma membrane | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|
| Keyword ID | Keyword Term |
|---|---|
| KW-0025 | Alternative splicing |
| KW-0090 | Biological rhythms |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0391 | Immunity |
| KW-0399 | Innate immunity |
| KW-0433 | Leucine-rich repeat |
| KW-0472 | Membrane |
| KW-0597 | Phosphoprotein |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0744 | Spermatogenesis |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |