| Tag | Content |
|---|---|
| Uniprot ID | E7FE13 |
| Entrez ID | 558825 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_682092.8 |
| Ensembl protein ID | ENSDARP00000137036 |
| Ensembl nucleotide ID | ENSDARG00000060542 |
| Gene name | Leucine-rich repeat-containing G-protein coupled receptor 4 |
| Gene symbol | lgr4 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May play a role in regulating the circadian rhythms of plasma lipids. |
| Sequence | MALLAVRMLV LGLCVGGQAA AAGEGQSTPA TCSPLCRCDE DGGADCSGRG LTSVPTGLSA 60 FTYYLDISMN NITELPANVF RNLPYLEELR LAGNDLAFIH PEALSGLHQL KVLMLQNNQL 120 KTVPSAALKN LNALQSLRLD ANHITSVPED SFEGLQQLRH LWLDDNSLTE VPISPLQHQS 180 NLQALTLALN RITHIPDNAF ANLSSLVVLH LHNNRIQEIG KNCFNGLDNL ETLDLNFNNL 240 KIFPEAIQML PKLKELGFHS NNIASIPEGA FCRNSLLRTI HLFDNPLSFV GTTAFQNLSD 300 LHSLMLRGAS MMQDFPSLTG TINLESLTLT GTKIRSIPAD LCEDLTVLRT VDLSYNDIED 360 LPSFQGCVRL QDINLQHNQI KQIDRGTFQG MTSLRVLDLS RNQIKFIHRD AFLSLSALTN 420 LDLSLNSLAS VPTAGLSALN QLKLTGNMEL RNGLMSKTLP KLRSITVPYA YQCCAFVAYD 480 SAVNPAEDDE RRNAFGGEED MERIPMVMHC SPLPGAFKPC EHLLGSWMIR LTVWFICLVA 540 LLFNCLVLAA TFSPRTSSLS PSRFLVALLA SANLLTGVYV AALTLLDTVT WGSFAEYGVW 600 WETGAGCQVV GFLAVFSSEW AVLLLALAAV ERCLAVRALM GKAGALRSRG ERRERRRRFA 660 IAALLLGLVS VAAACLSLYH GSAMGSPLCL PFSEGSSPGL GFTVALVLMN TLAYLLSAVV 720 YTRLYCRLGR AQLADPEQAG SVRHIAWLIF TNCIFFCPVA AFSFAPLLAG TSNAVGGPEM 780 AKSVTLIFFP LSACLNPVLY VCFSPSFRYD WLHLRGRGRT GGCGRLVAKT VTKGTVAGGS 840 PVSDDGEGLS SDCGMYTKLH GDSRGMCEHC DAALHIRTSS SSGSSSSSAC RHLVKSHSCP 900 ALMGNVPQCL SSEGYWPDTG TLSAQSEYGD EGDSFVSDSS EQVQACGRAC FCQSRGLPLV 960 HYSYNIPRMT D 971 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LGR4 | A0A452GBK2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | LGR4 | 55366 | Q9BXB1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Lgr4 | 107515 | A2ARI4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | LGR4 | H2R5I5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | LGR4 | 100518646 | F1SGM5 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | LGR4 | 100356429 | G1SL01 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Lgr4 | 286994 | Q9Z2H4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lgr4 | 558825 | E7FE13 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0031012 | extracellular matrix |
| GO:0005615 | extracellular space |
| GO:0005887 | integral component of plasma membrane |
| GO:0016500 | protein-hormone receptor activity |
| GO:0004888 | transmembrane signaling receptor activity |
| GO:0030282 | bone mineralization |
| GO:0046849 | bone remodeling |
| GO:0007186 | G protein-coupled receptor signaling pathway |
| GO:0001818 | negative regulation of cytokine production |
| GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| GO:0001649 | osteoblast differentiation |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0048511 | rhythmic process |
| GO:0007283 | spermatogenesis |
| GO:0016055 | Wnt signaling pathway |
| Keyword ID | Keyword Term |
|---|---|
| KW-0090 | Biological rhythms |
| KW-1003 | Cell membrane |
| KW-0217 | Developmental protein |
| KW-0221 | Differentiation |
| KW-1015 | Disulfide bond |
| KW-0297 | G-protein coupled receptor |
| KW-0325 | Glycoprotein |
| KW-0433 | Leucine-rich repeat |
| KW-0472 | Membrane |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0677 | Repeat |
| KW-0732 | Signal |
| KW-0807 | Transducer |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |
| KW-0879 | Wnt signaling pathway |