| Tag | Content |
|---|---|
| Uniprot ID | F1SGM5 |
| Entrez ID | 100518646 |
| Genbank protein ID | HDB61544.1; HDA53724.1; |
| Genbank nucleotide ID | XM_013994475.1 |
| Ensembl protein ID | ENSSSCP00000014168 |
| Ensembl nucleotide ID | ENSSSCG00000013335 |
| Gene name | Leucine rich repeat containing G protein-coupled receptor 4 |
| Gene symbol | LGR4 |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MPGPLGLLCF LALGLRCSAE PSGAAPSLCS APCSCDGDRR VDCSGKGLTA VPEGLSAFTQ 60 ALDISMNNIT QLPEDAFKNF PFLEELRLAG NDLSFIHPKA LSGLKELKVL TLQNNQLKTV 120 PSEAIRGLSA LQSLRLDANH ITSVPEDSFE GLTQLRHLWL DDNSLTEVPV QPLSNLPTLQ 180 ALTLALNKIS SIPDFAFTNL SSLVVLHLHN NKIKSLGQHC FDGLDNLETL DLNYNNLGEF 240 PQAIKALPSL KELLFHSNSI SVIPDGAFDG NPLLRTIHLY DNPLSFVGNS AFHNLSDLHS 300 LVIRGASMVQ RFPNLTGTVH LESLTLTGTK ISSISSNLCQ EQKMLRTLDL SYNNIKDLPS 360 FNGCYALEEI SLQRNQIHQI KEGTFQGLTS LRILDLSRNL IHEIHDRAFA KLGSITNLDI 420 SFNELTSFPT EGLNGLNQLK LVGNFKLKEA LAAKDFVNLR SLSVPYAYQC CAFWGCDSYA 480 HSNTDDNSLQ DYSVAKEKGS TDGTGVTSSV DNEEHSQIII HCTPSTGAFK PCEYLLGSWM 540 IRLTVWFIFL VALFFNLLVI LTTFASCTSL PSSKLFIGLI SVSNLFMGAY TGILTFLDAV 600 SWGRFAEFGI WWEIGSGCKI AGFLAVFSSE SAIFLLMLAA VERSLSAKDI MKNGKSDHLK 660 QFQIAAFFAF LGAAVAGCFP LFHGGEYSAS PLCLPFPTGE TPSLGFTVTL VLLNSLAFLL 720 MAIIYTKLYC NLEKEDLSEN SHSSMIKHVA WLIFTNCIFF CPVAFFSFAP LITAISISPE 780 IMKSVTLIFF PLPACLNPVL YVFFNPKFKE DWKLLKRHIT KKSGSVSVST SSQAGCVDQD 840 FYYDCGMYSH LQGNLSVCDC CESFLLTKPV SCKHLIKSHS CPALAVGSCQ RPDGYWSDCG 900 TQSAHSDYAD EEDSFVSDSS DQVQACGRAC FYQSRGFPLV RYAYNLPRVK D 951 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | LGR4 | A0A452GBK2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | LGR4 | 55366 | Q9BXB1 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Lgr4 | 107515 | A2ARI4 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | LGR4 | H2R5I5 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | LGR4 | 100518646 | F1SGM5 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | LGR4 | 100356429 | G1SL01 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Lgr4 | 286994 | Q9Z2H4 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | lgr4 | 558825 | E7FE13 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005887 | integral component of plasma membrane |
| GO:0008528 | G protein-coupled peptide receptor activity |
| GO:0016500 | protein-hormone receptor activity |
| GO:0007190 | activation of adenylate cyclase activity |
| GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO:0030282 | bone mineralization |
| GO:0046849 | bone remodeling |
| GO:0061290 | canonical Wnt signaling pathway involved in metanephric kidney development |
| GO:0072202 | cell differentiation involved in metanephros development |
| GO:0032922 | circadian regulation of gene expression |
| GO:0048565 | digestive tract development |
| GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis |
| GO:0001942 | hair follicle development |
| GO:0009755 | hormone-mediated signaling pathway |
| GO:0036335 | intestinal stem cell homeostasis |
| GO:0030539 | male genitalia development |
| GO:0072224 | metanephric glomerulus development |
| GO:0072282 | metanephric nephron tubule morphogenesis |
| GO:0120163 | negative regulation of cold-induced thermogenesis |
| GO:0050710 | negative regulation of cytokine secretion |
| GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0001649 | osteoblast differentiation |
| GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0007283 | spermatogenesis |