Tag | Content |
---|---|
Uniprot ID | G1SL01 |
Entrez ID | 100356429 |
Genbank protein ID | |
Genbank nucleotide ID | XM_002709023.3 |
Ensembl protein ID | ENSOCUP00000003521 |
Ensembl nucleotide ID | ENSOCUG00000004061 |
Gene name | Leucine rich repeat containing G protein-coupled receptor 4 |
Gene symbol | LGR4 |
Organism | Oryctolagus cuniculus |
NCBI taxa ID | 9986 |
Cleft type | |
Developmental stage | |
Data sources | Homology search |
Reference | |
Functional description | |
Sequence | MPGPLGLLCF LALGLLGSAG LSGAAPPLCA ALCSCDGDRR VDCSGKGLTA VPEGLSAFTQ 60 ALDISMNNIT QLPEDAFKNF PFLEELQLAG NDLSFIHPKA LSGLKELKVL TLQNNQLKTV 120 PSEAIRGLST LQSLRLDANH ITSVPEDSFE GLVQLRHLWL DDNSLTEVPV HPLSHLPTLQ 180 ALTLALNKIS SIPDFAFTNL SSLVVLHLHN NKIKSLSPHC FDGLDNLETL DLNYNNLGEF 240 PQAIKALPSL KELGFHSNSI SVIPDGAFGG NPLLRTIHLY DNPLSFVGNT AFHNLSDLHS 300 LVIRGASMVQ SFPNLTGTVH LESLTLTGTK ISKIPSNLCQ EQKMLRTLDL SYNNIRDLPS 360 FNGCHALEEI SLQRNQIYQI KEGTFQGLGS LRILDLSRNL IHEIHSRAFA KLGPITNLDM 420 SFNELTSFPT EGLNGLNQLK LVGNFKLKEA LAAKDFVNLR SLSVPYAYQC CAFWGCDSYA 480 NINTEDNSLQ DHPVTKEKGT ADAANVTSSA ENEEHSQIII HCTPSTGAFK PCEYLLGSWM 540 IRLTVWFIFL VALSFNLLVT LTTFASCTSL PSSKLFIGLI SVSNLFMGIY SGILTFLDAV 600 SWGRFAEFGI WWETGSGCKV AGFLAVFSSE SAIFLLVLAA VERSLSAKEI MKNGKSNHLK 660 QFRVAALFAF LGAAVAGCFP LFHRGEYSAS PLCLPFPTGE TPSLGFTVTL VLLNSLAFLL 720 MAIIYTKLYC NLEKEDLSEN SQSSMIKHVA WLIFTNCIFF CPVAFFSFAP LITAISISPE 780 IMKSVTLIFF PLPACLNPVL YVFFNPKFKE DWKLLKRRLT KKNGSVSVSI SSQGGCVEQD 840 FYYDCGMYSH LQGNLTVCDC CESFLLTKPV SCKHLIKSHS CPALAVASCQ RPEGYWSDCG 900 TQSAHSDYAD EEDSFVSDSS DQVQACGRAC FYQSRGFPLV RYAYNLPRVK D 951 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
---|---|---|---|---|---|---|---|---|
1:1 ortholog | LGR4 | A0A452GBK2 | Capra hircus | Prediction | More>> | |||
1:1 ortholog | LGR4 | 55366 | Q9BXB1 | Homo sapiens | Prediction | More>> | ||
1:1 ortholog | Lgr4 | 107515 | A2ARI4 | CPO | Mus musculus | Publication | More>> | |
1:1 ortholog | LGR4 | H2R5I5 | Pan troglodytes | Prediction | More>> | |||
1:1 ortholog | LGR4 | 100518646 | F1SGM5 | Sus scrofa | Prediction | More>> | ||
1:1 ortholog | LGR4 | 100356429 | G1SL01 | Oryctolagus cuniculus | Prediction | More>> | ||
1:1 ortholog | Lgr4 | 286994 | Q9Z2H4 | Rattus norvegicus | Prediction | More>> | ||
1:1 ortholog | lgr4 | 558825 | E7FE13 | Danio rerio | Prediction | More>> |
GO ID | GO Term |
---|---|
GO:0005887 | integral component of plasma membrane |
GO:0004930 | G protein-coupled receptor activity |
GO:0016500 | protein-hormone receptor activity |
GO:0030282 | bone mineralization |
GO:0046849 | bone remodeling |
GO:0061290 | canonical Wnt signaling pathway involved in metanephric kidney development |
GO:0072202 | cell differentiation involved in metanephros development |
GO:0032922 | circadian regulation of gene expression |
GO:0048565 | digestive tract development |
GO:2001013 | epithelial cell proliferation involved in renal tubule morphogenesis |
GO:0001942 | hair follicle development |
GO:0036335 | intestinal stem cell homeostasis |
GO:0030539 | male genitalia development |
GO:0072224 | metanephric glomerulus development |
GO:0072282 | metanephric nephron tubule morphogenesis |
GO:0120163 | negative regulation of cold-induced thermogenesis |
GO:0050710 | negative regulation of cytokine secretion |
GO:0034122 | negative regulation of toll-like receptor signaling pathway |
GO:0045892 | negative regulation of transcription, DNA-templated |
GO:0001649 | osteoblast differentiation |
GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
GO:0090263 | positive regulation of canonical Wnt signaling pathway |
GO:0045893 | positive regulation of transcription, DNA-templated |
GO:0007283 | spermatogenesis |