Gene: BMP2

Basic information

Tag Content
Uniprot ID A5PJI9
Entrez ID 615037
Genbank protein ID AAI42130.1; AAI34683.1;
Genbank nucleotide ID NM_001099141.1
Ensembl protein ID ENSBTAP00000006739
Ensembl nucleotide ID ENSBTAG00000005111
Gene name BMP2 protein
Gene symbol BMP2
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MVAGTRCLLA LLLPQVLLGG AAGLIPELGR RKFAASAGRS SSQPSDDVLS EFELRLLSMF 60
GLKQRPTPSR DAVVPPYMLD LYRQHSGQPG APAPDHRLER AASLANTVRS FHHEESLEEL 120
PEMSGKTTRR FFFNLTSIPT EEFITSAELQ VFRKHMPEAL ENNSSFHHRI NIYEIIKPAT 180
ANSKFPVTRL LDTRLVTQNA SRWESFDVTP AVMRWTAQGL TNHGFVVEVA HPEDSHGASK 240
RHVRISRSLH QDEHSWSQIR PLLVTFGHDG KGHPLHRREK RQAKHKQRKR LKSSCKRHPL 300
YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC 360
VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR 395

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBMP2615037A5PJI9Bos taurusPredictionMore>>
1:1 orthologBMP2477162J9P401Canis lupus familiarisPredictionMore>>
1:1 orthologBMP2A0A452EEC2Capra hircusPredictionMore>>
1:1 orthologBMP2650P12643Homo sapiensPredictionMore>>
1:1 orthologBmp212156P21274CPOE12.5, E13.5, E14.5Mus musculusPublicationMore>>
1:1 orthologBMP2458090H2QJY1Pan troglodytesPredictionMore>>
1:1 orthologBMP2100157103A0A286ZZE2Sus scrofaPredictionMore>>
1:1 orthologBMP2G1T1R1Oryctolagus cuniculusPredictionMore>>
1:1 orthologBmp2G3V8W4Rattus norvegicusPredictionMore>>
1:1 orthologbmp2aB3DI86Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0070724 BMP receptor complex
GO:0009986 cell surface
GO:0005615 extracellular space
GO:0043231 intracellular membrane-bounded organelle
GO:0070700 BMP receptor binding
GO:0039706 co-receptor binding
GO:0005125 cytokine activity
GO:0008083 growth factor activity
GO:0019211 phosphatase activator activity
GO:0004745 retinol dehydrogenase activity
GO:0046332 SMAD binding
GO:0000187 activation of MAPK activity
GO:0003181 atrioventricular valve morphogenesis
GO:0030509 BMP signaling pathway
GO:0003130 BMP signaling pathway involved in heart induction
GO:0035630 bone mineralization involved in bone maturation
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0060317 cardiac epithelial to mesenchymal transition
GO:0055007 cardiac muscle cell differentiation
GO:0055008 cardiac muscle tissue morphogenesis
GO:0035051 cardiocyte differentiation
GO:0045165 cell fate commitment
GO:0071407 cellular response to organic cyclic compound
GO:0002062 chondrocyte differentiation
GO:0060128 corticotropin hormone secreting cell differentiation
GO:0035054 embryonic heart tube anterior/posterior pattern specification
GO:0003203 endocardial cushion morphogenesis
GO:0001837 epithelial to mesenchymal transition
GO:0001701 in utero embryonic development
GO:0006954 inflammatory response
GO:0048839 inner ear development
GO:0048762 mesenchymal cell differentiation
GO:0072138 mesenchymal cell proliferation involved in ureteric bud development
GO:0032348 negative regulation of aldosterone biosynthetic process
GO:0051042 negative regulation of calcium-independent cell-cell adhesion
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:2000726 negative regulation of cardiac muscle cell differentiation
GO:0045786 negative regulation of cell cycle
GO:0008285 negative regulation of cell population proliferation
GO:2000065 negative regulation of cortisol biosynthetic process
GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0045892 negative regulation of transcription, DNA-templated
GO:0003308 negative regulation of Wnt signaling pathway involved in heart development
GO:0007219 Notch signaling pathway
GO:0042475 odontogenesis of dentin-containing tooth
GO:0001649 osteoblast differentiation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060039 pericardium development
GO:0043065 positive regulation of apoptotic process
GO:0048711 positive regulation of astrocyte differentiation
GO:0030501 positive regulation of bone mineralization
GO:0061036 positive regulation of cartilage development
GO:0030335 positive regulation of cell migration
GO:0001938 positive regulation of endothelial cell proliferation
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0045600 positive regulation of fat cell differentiation
GO:0045666 positive regulation of neuron differentiation
GO:0042482 positive regulation of odontogenesis
GO:0045778 positive regulation of ossification
GO:0045669 positive regulation of osteoblast differentiation
GO:0033690 positive regulation of osteoblast proliferation
GO:1900745 positive regulation of p38MAPK cascade
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010922 positive regulation of phosphatase activity
GO:1902895 positive regulation of pri-miRNA transcription by RNA polymerase II
GO:0032092 positive regulation of protein binding
GO:0001934 positive regulation of protein phosphorylation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
GO:0060804 positive regulation of Wnt signaling pathway by BMP signaling pathway
GO:0031648 protein destabilization
GO:0006029 proteoglycan metabolic process
GO:0042487 regulation of odontogenesis of dentin-containing tooth
GO:0009617 response to bacterium
GO:0001666 response to hypoxia
GO:0060395 SMAD protein signal transduction
GO:0021537 telencephalon development
GO:0021978 telencephalon regionalization
GO:0060129 thyroid-stimulating hormone-secreting cell differentiation

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide