| Tag | Content |
|---|---|
| Uniprot ID | G1T1R1 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSOCUP00000010036 |
| Ensembl nucleotide ID | ENSOCUG00000011674 |
| Gene name | Bone morphogenetic protein 2 |
| Gene symbol | BMP2 |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | GKTTRRFFFN LTSIPPEEFI TSAELQVFRE QMQEALGDDS GFHHRINIYE IIKPATANSK 60 FPATRLLDTR LVNQNTSRWE SFDVTPAVMR WTAQGHANHG FVVEVTHLEE KQGVSKRHVR 120 ISRSLHPDEH SWSQIRPLLV TFGHDGKGHP LHRREKRQAK HKQRKRLKSS CKRHPLYVDF 180 SDVGWNDWIV APPGYHAFYC HGECPFPLAD HLNSTNHAIV QTLVNSVNSK IPKACCVPTE 240 LSAISMLYLD ENEKVVLKNY QDMVVEGCGC R 271 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMP2 | 615037 | A5PJI9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | 477162 | J9P401 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | A0A452EEC2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BMP2 | 650 | P12643 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmp2 | 12156 | P21274 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | BMP2 | 458090 | H2QJY1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | 100157103 | A0A286ZZE2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | G1T1R1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Bmp2 | G3V8W4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | bmp2a | B3DI86 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0070724 | BMP receptor complex |
| GO:0009986 | cell surface |
| GO:0005615 | extracellular space |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0070700 | BMP receptor binding |
| GO:0039706 | co-receptor binding |
| GO:0008083 | growth factor activity |
| GO:0019211 | phosphatase activator activity |
| GO:0046332 | SMAD binding |
| GO:0000187 | activation of MAPK activity |
| GO:0003130 | BMP signaling pathway involved in heart induction |
| GO:0035630 | bone mineralization involved in bone maturation |
| GO:0060317 | cardiac epithelial to mesenchymal transition |
| GO:0055007 | cardiac muscle cell differentiation |
| GO:0002062 | chondrocyte differentiation |
| GO:0032348 | negative regulation of aldosterone biosynthetic process |
| GO:0051042 | negative regulation of calcium-independent cell-cell adhesion |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:2000726 | negative regulation of cardiac muscle cell differentiation |
| GO:0045786 | negative regulation of cell cycle |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:2000065 | negative regulation of cortisol biosynthetic process |
| GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development |
| GO:0001649 | osteoblast differentiation |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0061036 | positive regulation of cartilage development |
| GO:0001938 | positive regulation of endothelial cell proliferation |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:1900745 | positive regulation of p38MAPK cascade |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0010922 | positive regulation of phosphatase activity |
| GO:0032092 | positive regulation of protein binding |
| GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| GO:0060395 | SMAD protein signal transduction |
| GO:0021537 | telencephalon development |