| Tag | Content |
|---|---|
| Uniprot ID | G3V8W4 |
| Entrez ID | |
| Genbank protein ID | EDL80282.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000028904 |
| Ensembl nucleotide ID | ENSRNOG00000021276 |
| Gene name | Bone morphogenetic protein 2 |
| Gene symbol | Bmp2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVAGTRCLLV LLLPQVLLGG AAGLIPELGR KKFAGASGRP LSRPSDDVLS EFELRLLSMF 60 GLKQRPTPSK DVVVPPYMLD LYRRHSGQPG APAPDHRLER AASRANTVRS FHHEEAIEEL 120 PEMSGKTSRR FFFNLSSVPT DEFLTSAELQ IFREQMQEAL GNSSFQHRIN IYEIIKPATA 180 SSKFPVTRLL DTRLVTQNTS QWESFDVTPA VMRWTAQGHT NHGFVVEVAH LEEKPGVSKR 240 HVRISRSLHQ DEHSWSQVRP LLVTFGHDGK GHPLHKREKR QAKHKQRKRL KSSCKRHPLY 300 VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV 360 PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR 394 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMP2 | 615037 | A5PJI9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | 477162 | J9P401 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | A0A452EEC2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BMP2 | 650 | P12643 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmp2 | 12156 | P21274 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | BMP2 | 458090 | H2QJY1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | 100157103 | A0A286ZZE2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | G1T1R1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Bmp2 | G3V8W4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | bmp2a | B3DI86 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0070724 | BMP receptor complex |
| GO:0009986 | cell surface |
| GO:0005615 | extracellular space |
| GO:0043231 | intracellular membrane-bounded organelle |
| GO:0070700 | BMP receptor binding |
| GO:0039706 | co-receptor binding |
| GO:0008083 | growth factor activity |
| GO:0019211 | phosphatase activator activity |
| GO:0004745 | retinol dehydrogenase activity |
| GO:0046332 | SMAD binding |
| GO:0000187 | activation of MAPK activity |
| GO:0003181 | atrioventricular valve morphogenesis |
| GO:0030509 | BMP signaling pathway |
| GO:0003130 | BMP signaling pathway involved in heart induction |
| GO:0035630 | bone mineralization involved in bone maturation |
| GO:0001658 | branching involved in ureteric bud morphogenesis |
| GO:0060317 | cardiac epithelial to mesenchymal transition |
| GO:0055007 | cardiac muscle cell differentiation |
| GO:0055008 | cardiac muscle tissue morphogenesis |
| GO:0045165 | cell fate commitment |
| GO:0071407 | cellular response to organic cyclic compound |
| GO:0002062 | chondrocyte differentiation |
| GO:0060128 | corticotropin hormone secreting cell differentiation |
| GO:0035054 | embryonic heart tube anterior/posterior pattern specification |
| GO:0003203 | endocardial cushion morphogenesis |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0001701 | in utero embryonic development |
| GO:0006954 | inflammatory response |
| GO:0048839 | inner ear development |
| GO:0048762 | mesenchymal cell differentiation |
| GO:0072138 | mesenchymal cell proliferation involved in ureteric bud development |
| GO:0032348 | negative regulation of aldosterone biosynthetic process |
| GO:0051042 | negative regulation of calcium-independent cell-cell adhesion |
| GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| GO:2000726 | negative regulation of cardiac muscle cell differentiation |
| GO:0045786 | negative regulation of cell cycle |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:2000065 | negative regulation of cortisol biosynthetic process |
| GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development |
| GO:0007219 | Notch signaling pathway |
| GO:0042475 | odontogenesis of dentin-containing tooth |
| GO:0001649 | osteoblast differentiation |
| GO:0060389 | pathway-restricted SMAD protein phosphorylation |
| GO:0060039 | pericardium development |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0048711 | positive regulation of astrocyte differentiation |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0061036 | positive regulation of cartilage development |
| GO:0030335 | positive regulation of cell migration |
| GO:0001938 | positive regulation of endothelial cell proliferation |
| GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| GO:0045600 | positive regulation of fat cell differentiation |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0042482 | positive regulation of odontogenesis |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0033690 | positive regulation of osteoblast proliferation |
| GO:1900745 | positive regulation of p38MAPK cascade |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0010922 | positive regulation of phosphatase activity |
| GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| GO:0032092 | positive regulation of protein binding |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| GO:0060804 | positive regulation of Wnt signaling pathway by BMP signaling pathway |
| GO:0031648 | protein destabilization |
| GO:0006029 | proteoglycan metabolic process |
| GO:0042487 | regulation of odontogenesis of dentin-containing tooth |
| GO:0009617 | response to bacterium |
| GO:0001666 | response to hypoxia |
| GO:0060395 | SMAD protein signal transduction |
| GO:0021978 | telencephalon regionalization |
| GO:0060129 | thyroid-stimulating hormone-secreting cell differentiation |