| Tag | Content |
|---|---|
| Uniprot ID | J9P401 |
| Entrez ID | 477162 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_534351.5 |
| Ensembl protein ID | ENSCAFP00000040280 |
| Ensembl nucleotide ID | ENSCAFG00000031497 |
| Gene name | Bone morphogenetic protein 2 |
| Gene symbol | BMP2 |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MVAGTRCLLA LLLPQVLLGG AAGLITELGR RKFAASPGRS PSQPSDEVLS EFELRLLSMF 60 GLKRRPTPSR DAVVPPYMLD LYRRHSGQPG APAPDHRLER AASLANTVRS FHHEESLEEL 120 PEMSGKTTRR FFFNLTSIPT DEFITSAELQ VFREQMQEPL ENDSNFHHRI NIYEIIKPAA 180 ANLKFPVTRL LDTRLVNQNA SRWESFDVTP AVMRWTAQGL ANHGFVVEVT HLEENQGVSK 240 RHVRISRSLH QDEHSWSQIR PLLVTFGHDG KGHPLHKREK RQAKHKQRKR LKSSCKRHPL 300 YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC 360 VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR 395 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMP2 | 615037 | A5PJI9 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | 477162 | J9P401 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | A0A452EEC2 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | BMP2 | 650 | P12643 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Bmp2 | 12156 | P21274 | CPO | E12.5, E13.5, E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | BMP2 | 458090 | H2QJY1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | 100157103 | A0A286ZZE2 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | BMP2 | G1T1R1 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Bmp2 | G3V8W4 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | bmp2a | B3DI86 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005615 | extracellular space |
| GO:0070700 | BMP receptor binding |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0046332 | SMAD binding |
| GO:0030509 | BMP signaling pathway |
| GO:0003130 | BMP signaling pathway involved in heart induction |
| GO:0035630 | bone mineralization involved in bone maturation |
| GO:0001837 | epithelial to mesenchymal transition |
| GO:0048762 | mesenchymal cell differentiation |
| GO:2000726 | negative regulation of cardiac muscle cell differentiation |
| GO:0045786 | negative regulation of cell cycle |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development |
| GO:0030501 | positive regulation of bone mineralization |
| GO:0001938 | positive regulation of endothelial cell proliferation |
| GO:0045669 | positive regulation of osteoblast differentiation |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0060395 | SMAD protein signal transduction |