Gene: NXN

Basic information

Tag Content
Uniprot ID A6QLU8
Entrez ID 531367
Genbank protein ID AAI48093.1
Genbank nucleotide ID NM_001102136.1
Ensembl protein ID ENSBTAP00000001140
Ensembl nucleotide ID ENSBTAG00000000855
Gene name Nucleoredoxin
Gene symbol NXN
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A) (By similarity).
Sequence
MSGFLEELLG EKLVTGGGEE VDVHSLAARG ISLLGLYFGC SLSAPCAQLS ASLAAFYGRL 60
RGDAAAGPGP GPGAGASAEP EPRRRLEIVF VSSDQDQRQW QDFVRDMPWL ALPYKEKHRK 120
LKLWNKYRIS NIPSLIFLDA TSGKVVCRNG LLVIRDDPEG LEFPWGPKPF REVIAGPLLR 180
SNGQSLESSS LEGSHVGVYF SAHWCPPCRS LTRVLVESYR KIKEAGQKFE IIFVSADRSE 240
DSFKQYFSEM PWLAVPYTDE ARRSRLNRLY GIQGIPTLIV LDPQGEVITR QGRVEVLNDE 300
DCRGFPWHPK PVLELSDSNA VQLNEGPCLV LFVDSEDDGE SEAAKQLIQP IAEKIIAKYK 360
AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM SARAKYVMDV EEITPAIVEA 420
FVNDFLAEKL KPEPI 435

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNXN531367A6QLU8Bos taurusPredictionMore>>
1:1 orthologNXN611162J9NXW0Canis lupus familiarisPredictionMore>>
1:1 orthologNXNA0A452F4G8Capra hircusPredictionMore>>
1:1 orthologNXN64359Q6DKJ4Homo sapiensPredictionMore>>
1:1 orthologNxn18230P97346CPOMus musculusPublicationMore>>
1:1 orthologNXN746905K7DKH1Pan troglodytesPredictionMore>>
1:1 orthologNXNI3LEF2Sus scrofaPredictionMore>>
1:1 orthologNXN100338429G1SNE1Oryctolagus cuniculusPredictionMore>>
1:1 orthologNxn360577D4A0M2Rattus norvegicusPredictionMore>>
1:1 ortholognxnF1R5G2Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005623 cell
GO:0005829 cytosol
GO:0005634 nucleus
GO:0047134 protein-disulfide reductase activity
GO:0004791 thioredoxin-disulfide reductase activity
GO:0072358 cardiovascular system development
GO:0030154 cell differentiation
GO:0045454 cell redox homeostasis
GO:0001701 in utero embryonic development
GO:0031397 negative regulation of protein ubiquitination
GO:0030178 negative regulation of Wnt signaling pathway
GO:0016055 Wnt signaling pathway

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0520 NAD
KW-0539 Nucleus
KW-0560 Oxidoreductase
KW-1185 Reference proteome
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR041861 NRX_PDI_b
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain

PROSITE

PROSITE ID PROSITE Term
PS51352 THIOREDOXIN_2

Pfam

Pfam ID Pfam Term
PF13905 Thioredoxin_8