Gene: Nxn

Basic information

Tag Content
Uniprot ID P97346; Q5H8T6; Q5H8U0; Q99KF3;
Entrez ID 18230
Genbank protein ID BAD88799.1; BAD88801.1; BAD88802.1; AAH04688.1; BAD88800.1; BAD88798.1; BAD88804.1; BAD88805.1; BAD88803.1; BAE28730.1; AAH58244.1; CAA63408.1;
Genbank nucleotide ID NM_008750.5
Ensembl protein ID ENSMUSP00000021204
Ensembl nucleotide ID ENSMUSG00000020844
Gene name Nucleoredoxin
Gene symbol Nxn
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 27933520
Functional description Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A).
Sequence
MSGFLEELLG DKLVTGGGEE VDVHSLGARG IALLGLYFGC SLSAPCAQLS ASLAAFYGRL 60
RGDAAAGPGA GAGAGAAAEP EPRHRLEIVF VSSDQDQRQW QDFVRDMPWL ALPYKEKHRK 120
LKLWNKYRVS NIPSLIFLDA TTGKVVCRNG LLVIRDDPEG LEFPWGPKPF REVIAGPLLR 180
NNGQSLESSS LEGSHVGVYF SAHWCPPCRS LTRVLVESYR KIKEAGQEFE IIFVSADRSE 240
ESFKQYFSEM PWLAVPYTDE ARRSRLNRLY GIQGIPTLIV LDPQGEVITR QGRVEVLNDE 300
DCREFPWHPK PVLELSDSNA VQLNEGPCLV LFVDSEDDGE SEAAKQLIQP IAEKIIAKYK 360
AKEEEAPLLF FVAGEDDMTD SLRDYTNLPE AAPLLTILDM SARAKYVMDV EEITPAIVET 420
FVNDFLAEKL KPEPI 435

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologNXN531367A6QLU8Bos taurusPredictionMore>>
1:1 orthologNXN611162J9NXW0Canis lupus familiarisPredictionMore>>
1:1 orthologNXNA0A452F4G8Capra hircusPredictionMore>>
1:1 orthologNXN64359Q6DKJ4Homo sapiensPredictionMore>>
1:1 orthologNxn18230P97346CPOMus musculusPublicationMore>>
1:1 orthologNXN746905K7DKH1Pan troglodytesPredictionMore>>
1:1 orthologNXNI3LEF2Sus scrofaPredictionMore>>
1:1 orthologNXN100338429G1SNE1Oryctolagus cuniculusPredictionMore>>
1:1 orthologNxn360577D4A0M2Rattus norvegicusPredictionMore>>
1:1 ortholognxnF1R5G2Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004791 thioredoxin-disulfide reductase activityIDA
GO:0005515 protein bindingIPI
GO:0047134 protein-disulfide reductase activityIEA

GO:Biological Process

GO ID GO Term Evidence
GO:0001701 in utero embryonic developmentIMP
GO:0016055 Wnt signaling pathwayIEA
GO:0030154 cell differentiationIEA
GO:0030178 negative regulation of Wnt signaling pathwayIMP
GO:0031397 negative regulation of protein ubiquitinationIMP
GO:0045454 cell redox homeostasisIEA
GO:0055114 oxidation-reduction processIEA
GO:0072358 cardiovascular system developmentIMP
GO:0098869 cellular oxidant detoxificationIEA

GO:Cellular Component

GO ID GO Term Evidence
GO:0005623 cellIEA
GO:0005634 nucleusIDA
GO:0005829 cytosolIEA

Reactome Pathway

Reactome ID Reactome Term Evidence

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0025 Alternative splicing
KW-0963 Cytoplasm
KW-0217 Developmental protein
KW-0221 Differentiation
KW-0520 NAD
KW-0539 Nucleus
KW-0560 Oxidoreductase
KW-1185 Reference proteome
KW-0879 Wnt signaling pathway

Interpro

InterPro ID InterPro Term
IPR041861 NRX_PDI_b
IPR012336 Thioredoxin-like_fold
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain

PROSITE

PROSITE ID PROSITE Term
PS51352 THIOREDOXIN_2

Pfam

Pfam ID Pfam Term
PF13905 Thioredoxin_8

Protein-protein interaction

Protein-miRNA interaction