| Tag | Content |
|---|---|
| Uniprot ID | I3LEF2 |
| Entrez ID | |
| Genbank protein ID | HDC51043.1 |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSSSCP00000022440 |
| Ensembl nucleotide ID | ENSSSCG00000028720 |
| Gene name | Nucleoredoxin |
| Gene symbol | NXN |
| Organism | Sus scrofa |
| NCBI taxa ID | 9823 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSGFLEELLG EKLVTGGGEE VDVHSLGARG ISLLGLYFGC SLSAPCAQLS ASLAAFYSRL 60 RGDAAAGLGA GAGPGPGAGA AAEPEPRRRL EIVFVSSDQD QRQWQDFVRD MPWLALPYKE 120 KHRKLKLWNK YRISNIPSLI FLDATTGKVV CRNGLLVIRD DPEGLEFPWG PKPFREVIAG 180 PLLRNNGPAL ESSSLEGSHV GVYFSAHWCP PCRSLTRVLV ESYRKIKEAG QKFEIIFVSA 240 DRSEDSFKQY FSEMPWLAVP YTDEARRSRL NRLYGIQGIP TLIVLDPQGE VITRQGRVEV 300 LNDEDCRGFP WHPKPVLELS DSNAVQLNEG PCLVLFVDSE DDGESEAAKQ LIQPIAEKII 360 AKYKAKEEEA PLLFFVAGED DMTDSLRDYT NLPEAAPLLT ILDMSARAKY VMDVEEITPA 420 IVEAFVNDFL AEKLKPEPI 439 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NXN | 531367 | A6QLU8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NXN | 611162 | J9NXW0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | NXN | A0A452F4G8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NXN | 64359 | Q6DKJ4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nxn | 18230 | P97346 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NXN | 746905 | K7DKH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NXN | I3LEF2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | NXN | 100338429 | G1SNE1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Nxn | 360577 | D4A0M2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nxn | F1R5G2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005634 | nucleus |
| GO:0004791 | thioredoxin-disulfide reductase activity |
| GO:0072358 | cardiovascular system development |
| GO:0045454 | cell redox homeostasis |
| GO:0001701 | in utero embryonic development |
| GO:0031397 | negative regulation of protein ubiquitination |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0016055 | Wnt signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51352 | THIOREDOXIN_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF13905 | Thioredoxin_8 |