| Tag | Content |
|---|---|
| Uniprot ID | D4A0M2 |
| Entrez ID | 360577 |
| Genbank protein ID | EDM05259.1 |
| Genbank nucleotide ID | NM_001108285.1 |
| Ensembl protein ID | ENSRNOP00000047264 |
| Ensembl nucleotide ID | ENSRNOG00000008178 |
| Gene name | Nucleoredoxin |
| Gene symbol | Nxn |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MSVFLEELLG DKLVTGGGEE VDVHSLGARG IALLGLYFGC SLSAPCAQLS ASLALKLWNK 60 YRVSNIPSLI FLDATTGKVV CRNGLLVIRD DPEGLEFPWG PKPFREVIAG PLLRNNGQSL 120 ESSSLEGSHV GVYFSAHWCP PCRSLTRVLV ESYRKIKEAG QKFEIIFVSA DRSEESFKQY 180 FSEMPWLAVP YTDEARRSRL NRLYGIQGIP TLIVLDPQGE VITRQGRVEV LNDEDCREFP 240 WHPKPVLELS DSNAVQLNEG PCLVLFVDSE DDGESEAAKQ LIQPIAEKII AKYKAKEEEA 300 PLLFFVAGED DMTDSLRDYT NLPEAAPLLT ILDMSARAKY VMDVEEITPA IVETFVNDFL 360 AEKLKPEPI 369 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | NXN | 531367 | A6QLU8 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | NXN | 611162 | J9NXW0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | NXN | A0A452F4G8 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | NXN | 64359 | Q6DKJ4 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Nxn | 18230 | P97346 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | NXN | 746905 | K7DKH1 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | NXN | I3LEF2 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | NXN | 100338429 | G1SNE1 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Nxn | 360577 | D4A0M2 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | nxn | F1R5G2 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0005634 | nucleus |
| GO:0004791 | thioredoxin-disulfide reductase activity |
| GO:0072358 | cardiovascular system development |
| GO:0045454 | cell redox homeostasis |
| GO:0001701 | in utero embryonic development |
| GO:0031397 | negative regulation of protein ubiquitination |
| GO:0030178 | negative regulation of Wnt signaling pathway |
| GO:0016055 | Wnt signaling pathway |
| PROSITE ID | PROSITE Term |
|---|---|
| PS51352 | THIOREDOXIN_2 |
| Pfam ID | Pfam Term |
|---|---|
| PF13905 | Thioredoxin_8 |