| Tag | Content |
|---|---|
| Uniprot ID | A7YWG6; F1N2N6; |
| Entrez ID | 407128 |
| Genbank protein ID | AAI34548.1 |
| Genbank nucleotide ID | NM_001105328.1; XM_010805977.1; XM_010805980.2; XM_005207720.3; XM_010805976.1; |
| Ensembl protein ID | ENSBTAP00000002690; ENSBTAP00000061355; ENSBTAP00000073830; |
| Ensembl nucleotide ID | ENSBTAG00000002081 |
| Gene name | Serine/threonine-protein kinase receptor |
| Gene symbol | BMPR1B |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MLLRSSGKLS VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60 DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120 GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQEARPRYS IGLEQDETYI PPGESLRDLI 180 EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240 WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300 MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360 TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420 EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480 RLTALRVKKT LAKMSESQDI KL 502 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMPR1B | 407128 | A7YWG6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 100861211 | B5AFX6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 658 | O00238 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Bmpr1b | 12167 | P36898 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 396691 | Q95L23 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 100351275 | G1T8L9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1b | 310914 | M0R3J4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0016021 | integral component of membrane |
| GO:0005886 | plasma membrane |
| GO:0043235 | receptor complex |
| GO:0005524 | ATP binding |
| GO:0046872 | metal ion binding |
| GO:0004674 | protein serine/threonine kinase activity |
| GO:0046332 | SMAD binding |
| GO:0005025 | transforming growth factor beta receptor activity, type I |
| GO:0030509 | BMP signaling pathway |
| GO:0071363 | cellular response to growth factor stimulus |
| GO:0002063 | chondrocyte development |
| GO:0009953 | dorsal/ventral pattern formation |
| GO:0060350 | endochondral bone morphogenesis |
| GO:1902731 | negative regulation of chondrocyte proliferation |
| GO:0061036 | positive regulation of cartilage development |
| GO:0006468 | protein phosphorylation |
| GO:0030166 | proteoglycan biosynthetic process |
| Keyword ID | Keyword Term |
|---|---|
| KW-0067 | ATP-binding |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |