Gene: BMPR1B

Basic information

Tag Content
Uniprot ID A7YWG6; F1N2N6;
Entrez ID 407128
Genbank protein ID AAI34548.1
Genbank nucleotide ID NM_001105328.1; XM_010805977.1; XM_010805980.2; XM_005207720.3; XM_010805976.1;
Ensembl protein ID ENSBTAP00000002690; ENSBTAP00000061355; ENSBTAP00000073830;
Ensembl nucleotide ID ENSBTAG00000002081
Gene name Serine/threonine-protein kinase receptor
Gene symbol BMPR1B
Organism Bos taurus
NCBI taxa ID 9913
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
MLLRSSGKLS VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60
DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKNRDFVD 120
GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQEARPRYS IGLEQDETYI PPGESLRDLI 180
EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240
WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDTKS 300
MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360
TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEV ARRCVSGGIV 420
EEYQLPYHDL VPSDPSYEDM REIVCIKKLR PSFPNRWSSD ECLRQMGKLM TECWAHNPAS 480
RLTALRVKKT LAKMSESQDI KL 502

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologBMPR1B407128A7YWG6Bos taurusPredictionMore>>
1:1 orthologBMPR1B100861211B5AFX6Capra hircusPredictionMore>>
1:1 orthologBMPR1B658O00238Homo sapiensPublicationMore>>
1:1 orthologBmpr1b12167P36898Mus musculusPredictionMore>>
1:1 orthologBMPR1B396691Q95L23Sus scrofaPredictionMore>>
1:1 orthologBMPR1B100351275G1T8L9Oryctolagus cuniculusPredictionMore>>
1:1 orthologBmpr1b310914M0R3J4Rattus norvegicusPredictionMore>>

Gene ontology

GO ID GO Term
GO:0016021 integral component of membrane
GO:0005886 plasma membrane
GO:0043235 receptor complex
GO:0005524 ATP binding
GO:0046872 metal ion binding
GO:0004674 protein serine/threonine kinase activity
GO:0046332 SMAD binding
GO:0005025 transforming growth factor beta receptor activity, type I
GO:0030509 BMP signaling pathway
GO:0071363 cellular response to growth factor stimulus
GO:0002063 chondrocyte development
GO:0009953 dorsal/ventral pattern formation
GO:0060350 endochondral bone morphogenesis
GO:1902731 negative regulation of chondrocyte proliferation
GO:0061036 positive regulation of cartilage development
GO:0006468 protein phosphorylation
GO:0030166 proteoglycan biosynthetic process

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0067 ATP-binding
KW-0418 Kinase
KW-0460 Magnesium
KW-0464 Manganese
KW-0472 Membrane
KW-0479 Metal-binding
KW-0547 Nucleotide-binding
KW-0675 Receptor
KW-1185 Reference proteome
KW-0723 Serine/threonine-protein kinase
KW-0808 Transferase
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR000472 Activin_recp
IPR003605 GS_dom
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008271 Ser/Thr_kinase_AS
IPR000333 TGFB_receptor

PROSITE

PROSITE ID PROSITE Term
PS51256 GS
PS00107 PROTEIN_KINASE_ATP
PS50011 PROTEIN_KINASE_DOM
PS00108 PROTEIN_KINASE_ST

Pfam

Pfam ID Pfam Term
PF01064 Activin_recp
PF07714 Pkinase_Tyr
PF08515 TGF_beta_GS