| Tag | Content |
|---|---|
| Uniprot ID | P36898; Q3TRF2; |
| Entrez ID | 12167 |
| Genbank protein ID | BAE37078.1; AAH65106.1; CAA80674.1; AAH65143.1; BAC39617.1; |
| Genbank nucleotide ID | NM_001277218.1; NM_007560.4; NM_001277220.1; XM_006500939.3; XM_006500940.3; XM_006500942.1; XM_006500943.3; XM_011240001.1; NM_001277216.1; XM_006500944.2; NM_001277217.1; XM_011240002.2; |
| Ensembl protein ID | ENSMUSP00000101837; ENSMUSP00000101839; ENSMUSP00000029948; ENSMUSP00000096167; |
| Ensembl nucleotide ID | ENSMUSG00000052430 |
| Gene name | Bone morphogenetic protein receptor type-1B |
| Gene symbol | Bmpr1b |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP7/OP-1. Receptor for GDF5 (PubMed:26105076, PubMed:19229295). Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). |
| Sequence | MLLRSSGKLN VGTKKEDGES TAPTPRPKIL RCKCHHHCPE DSVNNICSTD GYCFTMIEED 60 DSGMPVVTSG CLGLEGSDFQ CRDTPIPHQR RSIECCTERN ECNKDLHPTL PPLKDRDFVD 120 GPIHHKALLI SVTVCSLLLV LIILFCYFRY KRQEARPRYS IGLEQDETYI PPGESLRDLI 180 EQSQSSGSGS GLPLLVQRTI AKQIQMVKQI GKGRYGEVWM GKWRGEKVAV KVFFTTEEAS 240 WFRETEIYQT VLMRHENILG FIAADIKGTG SWTQLYLITD YHENGSLYDY LKSTTLDAKS 300 MLKLAYSSVS GLCHLHTEIF STQGKPAIAH RDLKSKNILV KKNGTCCIAD LGLAVKFISD 360 TNEVDIPPNT RVGTKRYMPP EVLDESLNRN HFQSYIMADM YSFGLILWEI ARRCVSGGIV 420 EEYQLPYHDL VPSDPSYEDM REIVCMKKLR PSFPNRWSSD ECLRQMGKLM TECWAQNPAS 480 RLTALRVKKT LAKMSESQDI KL 502 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | BMPR1B | 407128 | A7YWG6 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 100861211 | B5AFX6 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 658 | O00238 | Homo sapiens | Publication | More>> | ||
| 1:1 ortholog | Bmpr1b | 12167 | P36898 | Mus musculus | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 396691 | Q95L23 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | BMPR1B | 100351275 | G1T8L9 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Bmpr1b | 310914 | M0R3J4 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004674 | protein serine/threonine kinase activity | ISO |
| GO:0004674 | protein serine/threonine kinase activity | IBA |
| GO:0004675 | transmembrane receptor protein serine/threonine kinase activity | ISO |
| GO:0005024 | transforming growth factor beta-activated receptor activity | TAS |
| GO:0005025 | transforming growth factor beta receptor activity, type I | IMP |
| GO:0005025 | transforming growth factor beta receptor activity, type I | IBA |
| GO:0005515 | protein binding | IPI |
| GO:0005524 | ATP binding | ISO |
| GO:0046332 | SMAD binding | ISO |
| GO:0046332 | SMAD binding | IBA |
| GO:0046872 | metal ion binding | IEA |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001501 | skeletal system development | ISO |
| GO:0001502 | cartilage condensation | IMP |
| GO:0001550 | ovarian cumulus expansion | IMP |
| GO:0001654 | eye development | IMP |
| GO:0002062 | chondrocyte differentiation | IGI |
| GO:0002062 | chondrocyte differentiation | IMP |
| GO:0002063 | chondrocyte development | ISS |
| GO:0006468 | protein phosphorylation | ISO |
| GO:0006468 | protein phosphorylation | IBA |
| GO:0006703 | estrogen biosynthetic process | NAS |
| GO:0006954 | inflammatory response | IEP |
| GO:0007178 | transmembrane receptor protein serine/threonine kinase signaling pathway | IGI |
| GO:0007179 | transforming growth factor beta receptor signaling pathway | TAS |
| GO:0009953 | dorsal/ventral pattern formation | IGI |
| GO:0009953 | dorsal/ventral pattern formation | IBA |
| GO:0030154 | cell differentiation | IMP |
| GO:0030154 | cell differentiation | IGI |
| GO:0030166 | proteoglycan biosynthetic process | ISS |
| GO:0030501 | positive regulation of bone mineralization | ISO |
| GO:0030509 | BMP signaling pathway | ISO |
| GO:0030509 | BMP signaling pathway | IMP |
| GO:0030509 | BMP signaling pathway | IGI |
| GO:0030509 | BMP signaling pathway | IBA |
| GO:0030509 | BMP signaling pathway | IDA |
| GO:0031290 | retinal ganglion cell axon guidance | IMP |
| GO:0032332 | positive regulation of chondrocyte differentiation | ISS |
| GO:0035108 | limb morphogenesis | ISO |
| GO:0042698 | ovulation cycle | IMP |
| GO:0043010 | camera-type eye development | IGI |
| GO:0045597 | positive regulation of cell differentiation | ISO |
| GO:0045669 | positive regulation of osteoblast differentiation | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | ISO |
| GO:0060041 | retina development in camera-type eye | IMP |
| GO:0060350 | endochondral bone morphogenesis | ISS |
| GO:0061036 | positive regulation of cartilage development | ISS |
| GO:0071363 | cellular response to growth factor stimulus | IBA |
| GO:0071363 | cellular response to growth factor stimulus | IDA |
| GO:0071773 | cellular response to BMP stimulus | ISO |
| GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | IGI |
| GO:1902731 | negative regulation of chondrocyte proliferation | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005886 | plasma membrane | IBA |
| GO:0005886 | plasma membrane | IDA |
| GO:0016021 | integral component of membrane | IEA |
| GO:0030425 | dendrite | IEA |
| GO:0043025 | neuronal cell body | IEA |
| GO:0043235 | receptor complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-201451 | Signaling by BMP | IEA |
| R-MMU-9006936 | Signaling by TGF-beta family members | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0067 | ATP-binding |
| KW-1003 | Cell membrane |
| KW-0891 | Chondrogenesis |
| KW-1015 | Disulfide bond |
| KW-0418 | Kinase |
| KW-0460 | Magnesium |
| KW-0464 | Manganese |
| KW-0472 | Membrane |
| KW-0479 | Metal-binding |
| KW-0547 | Nucleotide-binding |
| KW-0675 | Receptor |
| KW-1185 | Reference proteome |
| KW-0723 | Serine/threonine-protein kinase |
| KW-0732 | Signal |
| KW-0808 | Transferase |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |