| Tag | Content |
|---|---|
| Uniprot ID | A7YY57 |
| Entrez ID | 504657 |
| Genbank protein ID | AAI51352.1 |
| Genbank nucleotide ID | XM_005204266.2; XM_010803297.2; NM_001102485.1; |
| Ensembl protein ID | ENSBTAP00000005488; ENSBTAP00000069642; ENSBTAP00000072902; |
| Ensembl nucleotide ID | ENSBTAG00000004190 |
| Gene name | Rho GTPase-activating protein 29 |
| Gene symbol | ARHGAP29 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Has strong activity toward RHOA, and weaker activity toward RAC1 and CDC42. May act as a specific effector of RAP2A to regulate Rho (By similarity). In concert with RASIP1, suppresses RhoA signaling and dampens ROCK and MYH9 activities in endothelial cells and plays an essential role in blood vessel tubulogenesis (By similarity). |
| Sequence | MIAYKQKKTK KKRVLSTGQL STDVTTSEMG LKSINSNAIL DPDYIKELVN DIRKFSHMLL 60 YLKEAILSEC FKEVIHIRLD ELLRVLKSVM NKHQNLNSVD LQNAAEMLIA KVKAVNFTEV 120 NEENKNDLFR EVFSSIETLA FTFGNILTNF LMGDVGNDSL LRLPVSQESK SFESVSVESV 180 DSSNEKGSFS PIELDSMLLK NTNSVELALS YAKTWSKYTK NIVSWVEKKL NLELESTRNI 240 VKLAEATRTN IGLQEFMPLQ SLFTNALLND IESSHLLQQT IAALQANKFV QPLLGRKNEM 300 EKQRKEIKEL WKQEQNKMLE TETALKKAKL LCMQRQDEYE KAKSSMFRAE EEHLSSSSGL 360 VKNLNRQLEK KRRLEEEALQ KVEEANELYK VCVTNVEERR NDLENTKREI LTQLRKLVFQ 420 CDLTLKAVTV NLFQMQQLQA ASLSSNLQSL CDSAKLYDPG QEYSEFVRAT NSAEEEKVDG 480 NVNKQLSSPP ISGYGPSDSL EDVVRLPDSS NKMEEDRCSN SADITGPSFL RSWTFGMFSD 540 SESTGGSSES RSLDSESISP GDFHRKLPRT PSSGTMSSAD DLDEREPPSP SEAGPNSLGT 600 FKKTLMSKAA LTHKFRKLRS PTKCRDCEGI VVFHGVECEE CLLVCHRKCL ENLVIICGHQ 660 KLMGKIHLFG AEFTQVAKKE PDGIPFVLKM CASEIENRAL SLQGIYRVCG NKIKTEKLCQ 720 ALENGMHLVD ISEFSSHDIC DVLKLYLRQL PEPFILFRLY KEFIDLAVEI QHVNEEQEMK 780 KDNPEDKKWP SSSIEISRIL LKSKDLLRQL PASNFNSLHY LIVHLKRVVD HSEENKMNSR 840 NLGVIFGPSL LRPRPTTAPI TISSLADYSN QARLVEFLIT YSQKIFDGSL QPQDSAVGSA 900 GGIAPQVDPG YLPKSLLSPE ERDPERSMKS LFFSSKEDIQ TTDSECKSFE STPSFEESER 960 KQNALEKCDA YLIDNKGRLL VDQELESASR KTEDACKTSK LPTLKSDREI NGVERHLPRT 1020 RIRPVSLPID RLLLLASSPT ERNGRNMGNV NSDKLCKNPV FEGVNRKDSP TVVCSKFDGF 1080 DQQTLQKTRE KQYEQNDHTA KTGMIVPSAF QERGVALNIR SSGDHPVSIT QPSKPYTEPV 1140 RSTRQVSERR SSDSCPPASV RTPRTLQPQH WTTFYKPPAP AASGRGDEEK PVTPSVAVPP 1200 GTTHAPQEHV LKSVPGSENA SAGPVHPVSR PEEKAEERDQ PDVPTACQRP RLKRMQQFED 1260 LEDEIPQFV 1269 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ARHGAP29 | 504657 | A7YY57 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ARHGAP29 | 479940 | E2RRA9 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | ARHGAP29 | A0A452E8A9 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ARHGAP29 | 9411 | Q52LW3 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Arhgap29 | 214137 | Q8CGF1 | CPO | E13.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | ARHGAP29 | A0A2I3TR42 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ARHGAP29 | 100152734 | F1S540 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | ARHGAP29 | 100351674 | G1SXZ8 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Arhgap29 | 310833 | F1LPZ1 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005737 | cytoplasm |
| GO:0032991 | protein-containing complex |
| GO:0005096 | GTPase activator activity |
| GO:0046872 | metal ion binding |
| GO:0030165 | PDZ domain binding |
| GO:0035556 | intracellular signal transduction |
| Pfam ID | Pfam Term |
|---|---|
| PF00620 | RhoGAP |