Gene: qsox1

Basic information

Tag Content
Uniprot ID B0UXN0
Entrez ID 100004382
Genbank protein ID
Genbank nucleotide ID NM_001128364.1
Ensembl protein ID ENSDARP00000057644
Ensembl nucleotide ID ENSDARG00000039459
Gene name Sulfhydryl oxidase
Gene symbol qsox1
Organism Danio rerio
NCBI taxa ID 7955
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.
Sequence
MARRGCGATS CYTTKTKLNS FYSFLCAFIT CVSLCPVLCE AGLYTASDQV IVLTPENVDS 60
TLFNNTAALL VEFYATWCGH CIAFSPVWKS LARDIKEWKP AVDLAAIDCA NESNRKVCTN 120
FGITGYPSIK FFHAYSSIGS RGLEVRGFSR DVRGLRQYII ENLELHTEAW PPACPPLETA 180
SEAEVHHFFP ANNVKYLALV FENKKSYVGR EVTLDLLQYE NIAVRRVLDT ETNLVSRFGV 240
TEFPSCYLYD SSGNITRLKV LKEARTFYSY ALQRLPGVVR TGKHQTPITE LIKNSTLQEW 300
RPFNKSRVYM SDLESALHYS LRVELSSHTS ISGDDLIALK KYINVLAKYF PGRPSVKSAL 360
QAVDSWLQSQ KGTEIKYSDF RDVLDNVVQT SDAVLPEGVQ WVGCQGSQAR YRGYPCAVWT 420
LFHVLTVQAK EMGSTVSEPQ EVLLAMRGYV SSFFGCRPCA THFEAMAAES MDQVNSLSGA 480
VIWLWSRHNR VNNRLAGDLS EDPHFPKIQW PSPELCPSCH GVTIIGDHNW IKDEVPQFLQ 540
NYFSSSRILN DYLQDETQAL IQQRNRLTAA RMEKEAGRGA DRRARDIFDN NPADEPQEEE 600
EEEEEEEPTF EEQAVEPYPA GLEGAPGADQ APWEKPQPLS SQRKPKIVGM KLREAQEDIV 660
DLDYFVSQHY KAKALRAAAM SGVVRRRSLQ KKEDVEDLQF EGGWRVKRDL GSQEENFGIE 720
PYPRAQSKHW MSLLSVGFSR LDVSLCVLLY LLSTMCLLAM YMYFKLRIKL RSAKVSLP 778

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologQSOX1A0A5F4CZM1Canis lupus familiarisPredictionMore>>
1:1 orthologQSOX1A0A452FQZ4Capra hircusPredictionMore>>
1:1 orthologQSOX15768O00391Homo sapiensPredictionMore>>
1:1 orthologQsox1104009Q8BND5CPOMus musculusPublicationMore>>
1:1 orthologQSOX1457558K7DF20Pan troglodytesPredictionMore>>
1:1 orthologQSOX1F1S682Sus scrofaPredictionMore>>
1:1 orthologQSOX1100350171G1SND0Oryctolagus cuniculusPredictionMore>>
1:1 orthologQsox184491Q6IUU3Rattus norvegicusPredictionMore>>
1:1 orthologqsox1100004382B0UXN0Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0005615 extracellular space
GO:0030173 integral component of Golgi membrane
GO:0016971 flavin-linked sulfhydryl oxidase activity
GO:0003756 protein disulfide isomerase activity
GO:0006457 protein folding

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0274 FAD
KW-0285 Flavoprotein
KW-0472 Membrane
KW-0560 Oxidoreductase
KW-1185 Reference proteome
KW-0812 Transmembrane
KW-1133 Transmembrane helix

Interpro

InterPro ID InterPro Term
IPR036774 ERV/ALR_sulphydryl_oxid_sf
IPR017905 ERV/ALR_sulphydryl_oxidase
IPR040986 QSOX_FAD-bd_dom
IPR042568 QSOX_FAD-bd_sf
IPR041269 QSOX_Trx1
IPR039798 Sulfhydryl_oxidase
IPR036249 Thioredoxin-like_sf
IPR013766 Thioredoxin_domain

PROSITE

PROSITE ID PROSITE Term
PS51324 ERV_ALR
PS51352 THIOREDOXIN_2

Pfam

Pfam ID Pfam Term
PF04777 Evr1_Alr
PF18371 FAD_SOX
PF18108 QSOX_Trx1
PF00085 Thioredoxin