| Tag | Content |
|---|---|
| Uniprot ID | Q6IUU3; Q8K4M2; Q99J80; |
| Entrez ID | 84491 |
| Genbank protein ID | AAT40988.1; BAB21937.1; AAM67412.1; AAG53892.1; |
| Genbank nucleotide ID | NM_001109898.1; NM_053431.3; |
| Ensembl protein ID | ENSRNOP00000061072; ENSRNOP00000005052; |
| Ensembl nucleotide ID | ENSRNOG00000003649 |
| Gene name | Sulfhydryl oxidase 1 |
| Gene symbol | Qsox1 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:11278790). Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (By similarity). |
| Sequence | MRRCGRHSGP PSLLLLLLLL PPLLLSVPGA YAARLSVLYS SSDPLTLLDA DTVRPAVLGS 60 SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA VLDCADETNS AVCREFNIAG 120 FPTVRFFKAF SKNGTGTALP AAGANVQTLR MRLIDALESH RDTWPPACPP LEPAKLKDIN 180 EFFTRSKAEY LALIFEREDS YLGREVTLDL SQFHAVAVRR VLNSESDVVS KFAVTDFPSC 240 YLLLRNGSVS RVPVLVESRP FYTSYLRGLP GLTREAPPTT AAPVTPDKIA PTVWKFADRS 300 KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV QNFLHSINDW 360 LQKQQKKKIP YSYFKAALDS RKENAVLAEK VNWIGCQGSE PHFRGFPCSL WVLFHFLTVQ 420 AHRYSEAHPQ EPADGQEVLQ AMRSYVQSFF GCRDCANHFE QMAAASMHQV KSPSNAVLWL 480 WTSHNRVNAR LSGALSEDPQ FPKVQWPPRE LCSACHNEVN GQVPLWDLGA TLNFLKAHFS 540 PANIVRDPPA PGPASRRGTQ DPEASPNLVM DTLKLETGNS VLGHEQAASA ASPGATALDV 600 PAGKPEASGP QELNAGLSMG GASPGQGPPE HTEELLRDVQ ENAQGQQHLS KRDTEALLLP 660 EVNHLQGPLA PRRGGHSPKQ LASILEGEPE ALAIQGRRQW LQVLGGGVSF LDISLCVGLY 720 SVSFMGLLAM YTYFRARMRT PKGHVSYPTA |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | QSOX1 | A0A5F4CZM1 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | QSOX1 | A0A452FQZ4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | QSOX1 | 5768 | O00391 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Qsox1 | 104009 | Q8BND5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | QSOX1 | 457558 | K7DF20 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | QSOX1 | F1S682 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | QSOX1 | 100350171 | G1SND0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Qsox1 | 84491 | Q6IUU3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | qsox1 | 100004382 | B0UXN0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005623 | cell |
| GO:0070062 | extracellular exosome |
| GO:0005615 | extracellular space |
| GO:0000139 | Golgi membrane |
| GO:0030173 | integral component of Golgi membrane |
| GO:0045171 | intercellular bridge |
| GO:0071949 | FAD binding |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity |
| GO:0003756 | protein disulfide isomerase activity |
| GO:0045454 | cell redox homeostasis |
| GO:0085029 | extracellular matrix assembly |
| GO:0016242 | negative regulation of macroautophagy |
| GO:0006457 | protein folding |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0274 | FAD |
| KW-0285 | Flavoprotein |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-0472 | Membrane |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |