| Tag | Content |
|---|---|
| Uniprot ID | Q8BND5; Q3TDY9; Q3TE19; Q3TR29; Q3UEL4; Q8K041; Q9DBL6; |
| Entrez ID | 104009 |
| Genbank protein ID | BAE28897.1; BAE37202.1; BAB21936.1; BAE41807.1; AAH34131.1; BAC39073.1; AAH76590.1; BAE39061.1; BAE41459.1; BAB23638.1; BAE41429.1; |
| Genbank nucleotide ID | NM_001024945.1; NM_023268.2; |
| Ensembl protein ID | ENSMUSP00000142301; ENSMUSP00000107394; ENSMUSP00000035658; |
| Ensembl nucleotide ID | ENSMUSG00000033684 |
| Gene name | Sulfhydryl oxidase 1 |
| Gene symbol | Qsox1 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25807483 |
| Functional description | Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:26819240). Plays a role in disulfide bond formation in a variety of extracellular proteins (PubMed:26819240). In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (PubMed:26819240). |
| Sequence | MRRCGRLSGP PSLLLLLLLL SPLLFSGPGA YAARLSVLYS SSDPLTLLDA DSVRPTVLGS 60 SSAWAVEFFA SWCGHCIAFA PTWKELANDV KDWRPALNLA VLDCAEETNS AVCREFNIAG 120 FPTVRFFQAF TKNGSGATLP GAGANVQTLR MRLIDALESH RDTWPPACPP LEPAKLNDID 180 GFFTRNKADY LALVFEREDS YLGREVTLDL SQYHAVAVRR VLNTESDLVN KFGVTDFPSC 240 YLLLRNGSVS RVPVLVESRS FYTSYLRGLP GLTRDAPPTT ATPVTADKIA PTVWKFADRS 300 KIYMADLESA LHYILRVEVG KFSVLEGQRL VALKKFVAVL AKYFPGQPLV QNFLHSINDW 360 LQKQQKKRIP YSFFKAALDS RKEDAVLTEK VNWVGCQGSE PHFRGFPCSL WVLFHFLTVQ 420 ANRYSEAHPQ EPADGQEVLQ AMRSYVQFFF GCRDCADHFE QMAAASMHQV RSPSNAILWL 480 WTSHNRVNAR LSGALSEDPH FPKVQWPPRE LCSACHNELN GQVPLWDLGA TLNFLKAHFS 540 PANIVIDSSA SRHTGRRGSP EATPELVMDT LKLESRNSVL GHEQAASAES PGATALDVPA 600 EKPEASGPQE LYTGLRMGGA SPGQGPPERM EDHQRDMQEN APGQQHLSKR DTEALFLPEV 660 NHLQGPLELR RGGRSPKQLA PILEEEPEAL AIQGQGQWLQ VLGGGISHLD ISLCVGLYSV 720 SFMGLLAMYT YFRARLRTPK GHASYPTA 748 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | QSOX1 | A0A5F4CZM1 | Canis lupus familiaris | Prediction | More>> | |||
| 1:1 ortholog | QSOX1 | A0A452FQZ4 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | QSOX1 | 5768 | O00391 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Qsox1 | 104009 | Q8BND5 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | QSOX1 | 457558 | K7DF20 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | QSOX1 | F1S682 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | QSOX1 | 100350171 | G1SND0 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Qsox1 | 84491 | Q6IUU3 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | qsox1 | 100004382 | B0UXN0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0003756 | protein disulfide isomerase activity | ISS |
| GO:0003756 | protein disulfide isomerase activity | ISO |
| GO:0003756 | protein disulfide isomerase activity | IBA |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | ISS |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | ISO |
| GO:0016971 | flavin-linked sulfhydryl oxidase activity | IBA |
| GO:0071949 | FAD binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006457 | protein folding | IBA |
| GO:0016242 | negative regulation of macroautophagy | ISO |
| GO:0045454 | cell redox homeostasis | IEA |
| GO:0055114 | oxidation-reduction process | IEA |
| GO:0085029 | extracellular matrix assembly | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000139 | Golgi membrane | ISS |
| GO:0000139 | Golgi membrane | ISO |
| GO:0005615 | extracellular space | ISS |
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IBA |
| GO:0005615 | extracellular space | HDA |
| GO:0005623 | cell | IEA |
| GO:0005783 | endoplasmic reticulum | ISO |
| GO:0005794 | Golgi apparatus | ISO |
| GO:0030173 | integral component of Golgi membrane | ISS |
| GO:0030173 | integral component of Golgi membrane | ISO |
| GO:0030173 | integral component of Golgi membrane | IBA |
| GO:0043231 | intracellular membrane-bounded organelle | ISO |
| GO:0045171 | intercellular bridge | ISO |
| GO:0070062 | extracellular exosome | ISO |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-114608 | Platelet degranulation | IEA |
| R-MMU-168249 | Innate Immune System | IEA |
| R-MMU-168256 | Immune System | IEA |
| R-MMU-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-597592 | Post-translational protein modification | IEA |
| R-MMU-6798695 | Neutrophil degranulation | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-76005 | Response to elevated platelet cytosolic Ca2+ | IEA |
| R-MMU-8957275 | Post-translational protein phosphorylation | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0002 | 3D-structure |
| KW-0025 | Alternative splicing |
| KW-1015 | Disulfide bond |
| KW-0274 | FAD |
| KW-0285 | Flavoprotein |
| KW-0325 | Glycoprotein |
| KW-0333 | Golgi apparatus |
| KW-0472 | Membrane |
| KW-0560 | Oxidoreductase |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| KW-0812 | Transmembrane |
| KW-1133 | Transmembrane helix |