| Tag | Content |
|---|---|
| Uniprot ID | B1H0W0 |
| Entrez ID | 484067 |
| Genbank protein ID | AAY32934.1 |
| Genbank nucleotide ID | NM_001122602.1 |
| Ensembl protein ID | ENSCAFP00000036713 |
| Ensembl nucleotide ID | ENSCAFG00000000691 |
| Gene name | Cation-independent mannose-6-phosphate/insulin-like growth factor 2 receptor protein |
| Gene symbol | IGF2R |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGAAAGRSAH LGPGPAPAAR PLRSLVLLQL LLLVGAPGAA RAQGADFPEL CSYTWEAVDT 60 KNNMLYKINI CGNMNIDQCG LSSAVCMYDV KTNSYYSVGD FSSKTATRSL LEFSTTHSCK 120 QNPSHKIQSS ITFLCGKTLG TPEFVTATDC VHYFEWRTTA ACKKDTFKAK KEVPCYAFDG 180 ELKKHDLNPL IKISGGYLVD DSDPDTSLFI NVCRDIDSLR DSSLQLRGCP PGTAACLVRG 240 EQAFDVGQPK GGLKLLSTDR LVLSYVKEGA GELDFCDGHS PAVTITFVCP SERREGTIPK 300 LTAKSNCRYE IEWVTEYACH RDYLESRTCS LSSAQHDVTI DLQPLRQDGA SLSPYYTSDG 360 KEYMFYLNIC GEIQVPFCSK RDAAVCQVKK SDSSQVRVAG KYQNQTLRYS DGDLTLIYFG 420 GDECSSGFQR MSVINFECNK TAGNDGKGAP VFTGEMDCTY FFTWDTKYAC VKEKEDLLCS 480 VIDGKKRYDL SALARHSERE QNWEAVDGSE EEIGKKHYFI NICHRVLQEG QAKGCPEDAA 540 VCSVDKNGFK NLGKFISPPT KERGNLQLSY SDGSDCGHKK ITSNITLVCK PGDLESAPVL 600 RTSGDSGCFY EFEWHTAAAC VLSKTEGENC TVFDSQAGFS FDLSPLTKKN GAYKVDTEKY 660 DFYINVCGAV SVSFCQKDSG ACQIAKSDGK PWNLGVSNAK LSYYDGMIQL NYKDGTPYNN 720 EKHTPRATLI TFLCDREAGV GHPEYQEEDN STYNFRWYTS YACPEEPLEC VVTDPSTLEQ 780 YDLSSLAKSE GGRGGNWYAM DNAGEHSTWR KYYINVCRPL NPVPGCDRYA SVCQMKYKND 840 QGSFSEVASI SNLGVTKTGP TVEDSGSLLL EYVNGSECTT SDGKLTTYTT RIHLVCSRGS 900 MNTHPIFSLS WECVVSFLWN TEAACPIQIM TDTDQACSIR DPNSGFVFDL NPLNSSQGYV 960 VSGIGKTFVF NVCGTMPVCG TLDGKPASGC EAEFQTEDLK NLKPKRLVGL EKTLQLSTEG 1020 FITLTYKGPL SPSTGNSYAF IIRFVCNDDV YPGTIKFLHQ DIDSGLGIWN TFFEFETALA 1080 CVPSPVDCQV TDVAGNEYDL SGLSRVRKPW TAVDTSVDGR KRTFYLSVCN PLPYIPGCHG 1140 SAVGSCLVTE DNGWNLGVVQ ISPQAAENGS LSLVYVNGDK CGNQRFSTRI TLECAQTSGS 1200 PTFQLRDDCE YVFVWRTVEA CPVIRVEGDN CEVKDPRHGN LYDLKPLAVN DTIVSAGEYT 1260 YYFRVCGKLS SDVCPTDDKS KVISSCQEKR GPLGFHKVAG LLTQKLTYEN GLLKMNYTGG 1320 DTCHKVYQRS TTIFFYCDRS TQRPVFLRET SDCSYLFEWR TQYACAPFDL TECSFKDEAG 1380 NTFDLSSLAR YSDNWEAVTS TGATEHYLIN VCKSLSPQAG SEPCPPEAAA CLLSGSKPVN 1440 LGRVRDGPQW REGTIVLKYV DGDLCPDQIR KKSTTIRFTC SESQVNSRPM FISAVEDCEY 1500 TFSWPTAAAC PVRSNVHDNC QVTNPATGHL FDLSSLSGRA GHTAAYSEKG LVYISICEDN 1560 ENCSPGVGAC FGQTRISVGK ANKRLTYVDQ VLQLVYEDGS PCPSKSGLTY KSVISFVCRP 1620 EAGPTNRPML ISLDKQTCTL FFSWHTPLAC EQVTECSVRN GSSIIDLSPL IHRTGGYEAY 1680 DESEDDTSDT GPDFYINICQ PLNPMHGVPC PAGAAVCKVP VDGPPIDIGR VTGPPILNPI 1740 ANEVYLNFES STPCLADKHF NYTSLIAFHC RRGVSMGAPM LLRTSDCDFV FGWETPLVCP 1800 DEVKMDGCSL TDEQLHYSFN LSSLSKSTFK VTRDSRTYSI GVCTAAAGLD EGGCKDGGVC 1860 LLSGSKGASF GRLASMRLDY RHQDEAVILS YANGDNCPPE TEAGDPCVFP FIFNGKSYEE 1920 CVVEGRARLW CSTTANYDRD HEWGFCRHSN SHRMSSIIFK CDEDADIGRP QVFSEVRGCE 1980 VTFEWKTKVV CPPKKMECKF IQKHKTYDLR LLSSLTGSWF FVHEGVSYYI NLCQKIYKGP 2040 LDCSDRASIC KKSASGVVQA LGLVHTQKLD VLDDKVIVTY SKGYQCGENK TASAVIELTC 2100 AKTVGRPSFM RFDIDSCTYY FSWDSRAACA VKPQEVQMVN GTITNPINGK SFSLGDIYFK 2160 LFSASGDMRT NGDKYLYEIQ LSSITSSRNP ACSGANICQV KPNDQHFSRK VGTSDKTKYY 2220 IQDGDLDVVF ASSSKCGKDK TKSVSSTIFF HCDPLVKDGI PEFSHETADC QYLFSWYTSA 2280 VCPLGVDLDG DNAGEDTQEH KGLSERSQAV GAVLSLLLVA LTGCLLTLLL YKKERREIVV 2340 SRLTSCCRRS ANVSYKYSKV NKEEEADENE TEWLMEEIQA PTPRPGKEGQ ENGHITTKSV 2400 TAEALTSLHG DDQDSEDEVL TIPEVRVHSG RGTGAASVPH GRIPQRRGLR ESADGAGGLV 2460 TGDRVRRGKP RPVPQKTGTS GGLASFHDDS DEDLLHI 2497 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IGF2R | 484067 | B1H0W0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | IGF2R | 100860744 | A0A452E644 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | IGF2R | 3482 | P11717 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Igf2r | 16004 | Q07113 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | IGF2R | 463112 | H2QU01 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | IGF2R | F1SB67 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Igf2r | 25151 | G3V824 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | igf2r | 557061 | Q2TTK0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0005769 | early endosome |
| GO:0030139 | endocytic vesicle |
| GO:0005768 | endosome |
| GO:0016021 | integral component of membrane |
| GO:0005770 | late endosome |
| GO:0005641 | nuclear envelope lumen |
| GO:0005886 | plasma membrane |
| GO:0005802 | trans-Golgi network |
| GO:0030140 | trans-Golgi network transport vesicle |
| GO:0042802 | identical protein binding |
| GO:0005520 | insulin-like growth factor binding |
| GO:0005537 | mannose binding |
| GO:0051219 | phosphoprotein binding |
| GO:0038023 | signaling receptor activity |
| GO:0007041 | lysosomal transport |
| GO:0044794 | positive regulation by host of viral process |