| Tag | Content |
|---|---|
| Uniprot ID | G3V824 |
| Entrez ID | 25151 |
| Genbank protein ID | EDL83052.1 |
| Genbank nucleotide ID | NM_012756.2 |
| Ensembl protein ID | ENSRNOP00000021840 |
| Ensembl nucleotide ID | ENSRNOG00000014997 |
| Gene name | Insulin-like growth factor 2 receptor |
| Gene symbol | Igf2r |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MRAVLPGPVP SGPRVALLLP LLLLLLVAAA GSAQAQAVDL DALCSYTWEA VDSKNNAVYK 60 INPCGHVDNP RCGPTSAVCM CDLKSENCRS VGDSLLRSSA KSLLEFNTTT GCQPSEHRIQ 120 TSITFLCGKT LGTPEFVTAT DCVHYFEWRT TAACKKDIFK ADKEVPCYVF DDKLQKHDLN 180 PLIKLNGGYL VDDSDADASL FINVCRDIDS LRDPSTQLRV CPAGTAACLL KGNQAFDVGR 240 PKEGLKLLSK DRLVLTYVKE EGEKPDFCNG HSPAVTVTFV CPSERREGTI PKLTAKSNCR 300 YEVEWITEYA CHRDYLESET CSLSSEQHDI AIDLSPLAQH EEGSPYVADG GEYRFFMNVC 360 GDTKVSLCNK EAAVCQEKKV DSTQVKIAGR HQNQTLRYSD GDLTLIYSGG DECSSGFQRM 420 SVINFECNKT AGQDGRGEPV FTGEVDCTYF FTWDTKYACV KEKEDLLCGA IDGKKRYDLS 480 VLARHSESEQ NWEAVDGSQA ESEKRNFFIN VCHRVLQAGK AKNCPEGAAV CAVDKSGSKN 540 LGKFVSSPTK EKGHIQLSYS DGDDCGNDKK ITTNITFVCK PGDLESAPVL RAAGPDGCSY 600 EFEWHTAAAC VLSQTEGENC TVLDAQAGFS FDLSLLTKKN GAYKVETDKY DFYINVCGPV 660 SVNLCQSNSG ACQVAKSGKS WNLGLSNTKL TYYDGMIQLS YRNGTLYNNE KHTPRSTLIT 720 FLCDRDAGVG FPEYQEEDNS TYNFRWYTSY ACPEEPLECM VTDPSMMEQY DLSSLVKFEG 780 GRGGNWYAME NSREHFTRRK YYLNVCRPLN PVPGCDRYAS ACQMKYENNE GSLAETVAIS 840 NLGVAKTGPV VEESGSLLLE YVNGSACTTS DGRLTTYSTR IHLVCGRGTM NSHPIFTFNW 900 ECVVSFLWNT EAACPIQTIT DSDQACSIRD PNSGFVFNLS PLNYSQGHMV LGIGKTFVFN 960 ICGTMPACGT VAGKPALGCE AETKIKDIKD LKPERPVGME KSLQLSAEGF LTLTYKGSSP 1020 SDRGTAFIIR FICNGDIYPG TPKFLHQDID SARGIRNTFF EFETALACIP SVVDCQVTDP 1080 AGNEYDLSAL SMVRKPWTAV DTSVHGKKRR FYLSVCTPLP YIPGCDGIAM GSCMVSEDKS 1140 QNLGVVQISP QATGNGSLSI LYVNGDRCGN QRYSTRIVFE CAQTSGSPMF QLLNNCEYVF 1200 VWRTVEACPV VREEGDNCQV KDPRHGNLYD LKPLALNDTI ISAGEYTYYF RVCGKLSLDV 1260 CSAHDGSKAV SSCQEKKGPQ GFQKVAGLLN QKLTFENGLL KMNYSGGDTC HKVYQRSTTI 1320 YFYCDRTTQK PVFLKETLDC SYLFEWRTQY ACPPFNVTEC SIQDEAGNSI DLSSLSRYSD 1380 NWEAVTRTGA TEHYLINVCK SLSPQAGTDP CPPEAAVCLL DGSKPVNLGR VRDGPQWTAG 1440 VTVLKYVDGD LCPDKIRKRS TIIRFTCSDS QVNSRPLFIS AVQDCEYTFS WPTPAACPVK 1500 SNIHDDCQVT NPSTGHLFDL SSLSGKAGIT ASYSEKGMVF MSICEENVNC SPGVGACFGQ 1560 TRISVGQASK RLSYKDQVLQ LVYENGSPCP SKSGLRYKSV ISFVCRPEAG PTNRPMLISL 1620 DKQSCTLFFS WHTPLACEQA TECTVRNGSS IIDLSPLIHR TGGYEAYDES EDDTSDTTPD 1680 FYINICQPLN PMHGVPCPAG ASVCKVPVDG PPIDIGRVTG PPIFNPVANE VYLNFESSTP 1740 CLADKYMNYT SLIAFHCRRG ISMGTPKLIR NNDCDFVFEW ETPIVCPDEV KTQGCAVTDE 1800 QLLYSFNLTS LSTSTFKVTR DAHTYSIGVC TTAADLDQEG CKDGGVCLLS GSKGASFGRL 1860 ASMQLDYRHQ DEAVILSYVN GDPCPPETED GEPCVFPFIY KGETYDECVL EGRAKLWCSK 1920 TANYDRDHEW GFCRPSNSHR MSAIIFTCDE NEDIGRPEVF SEDRGCEVTF EWKTKVVCPP 1980 KKMECKFVQK HKTYDLRLLS SLTGSWDFVH EGNSYFINLC QRVYKGPLDC SERASICKKS 2040 ATGQVQVLGL VHTQKLEVID ETVLVTYSKG HSCGGNKTAS SVIELTCAKT VGRPAFKRFD 2100 IDSCTYYFYW YSRAACAVRP QEVNMVNGTL TNPVTGKSFS LGEIYFKLFS ASGDMRSNGD 2160 NYLYEIQLSS ISSSSNPACS GANICQVKPN DQHFSRKVGT SDMTKYYVQD GDLDVVFTSS 2220 STCGKDKTKS VSSTIFFHCD PLLKDGVPEF SHETADCQYL FSWYTSAVCP LGVDFDDENA 2280 VPEYKGLSER SQAVGAVLSL LLVALTGCLL ALLLHKKERR ETVINKLTNC CRRSSGVSYK 2340 YSKVSKEEET DENETEWLME EIQVPAARLG KDGQENGHIT TKTVKAEALT SLHGDDQDSE 2400 DEVLTIPEVK VHTGRGAEVE SSQPLRNPQR KVLKEREGER MGLVRGEKAR RGKFRPGQRK 2460 PTTPAKLVSF HDDSDEDLLH I 2481 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IGF2R | 484067 | B1H0W0 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | IGF2R | 100860744 | A0A452E644 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | IGF2R | 3482 | P11717 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Igf2r | 16004 | Q07113 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | IGF2R | 463112 | H2QU01 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | IGF2R | F1SB67 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | Igf2r | 25151 | G3V824 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | igf2r | 557061 | Q2TTK0 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0009986 | cell surface |
| GO:0030118 | clathrin coat |
| GO:0005769 | early endosome |
| GO:0030139 | endocytic vesicle |
| GO:0005768 | endosome |
| GO:0005615 | extracellular space |
| GO:0016021 | integral component of membrane |
| GO:0005770 | late endosome |
| GO:0016020 | membrane |
| GO:0005641 | nuclear envelope lumen |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0005886 | plasma membrane |
| GO:0005802 | trans-Golgi network |
| GO:0030140 | trans-Golgi network transport vesicle |
| GO:0019899 | enzyme binding |
| GO:0001965 | G-protein alpha-subunit binding |
| GO:0042802 | identical protein binding |
| GO:0005520 | insulin-like growth factor binding |
| GO:0031995 | insulin-like growth factor II binding |
| GO:0005010 | insulin-like growth factor-activated receptor activity |
| GO:0005537 | mannose binding |
| GO:0051219 | phosphoprotein binding |
| GO:0001972 | retinoic acid binding |
| GO:0031100 | animal organ regeneration |
| GO:0007186 | G protein-coupled receptor signaling pathway |
| GO:0001889 | liver development |
| GO:0007041 | lysosomal transport |
| GO:0044794 | positive regulation by host of viral process |
| GO:0043065 | positive regulation of apoptotic process |
| GO:0009791 | post-embryonic development |
| GO:0015031 | protein transport |
| GO:0042981 | regulation of apoptotic process |
| GO:0032526 | response to retinoic acid |
| GO:1904772 | response to tetrachloromethane |
| GO:0007283 | spermatogenesis |